دورية أكاديمية
Symplosaponins A-D: New acylated oleanane-type triterpene saponins from Symplocos cochinchinensis and their hepatoprotective effect.
| العنوان: | Symplosaponins A-D: New acylated oleanane-type triterpene saponins from Symplocos cochinchinensis and their hepatoprotective effect. |
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| المؤلفون: | Giang, Le Thi, Lee, Sion, Seo, Yohan, Cuong, Nguyen The, Tai, Bui Huu, Van Kiem, Phan, Hang, Nguyen Thi Minh, Oanh, Nguyen Thi Tu, Cuong, Pham Van, Ban, Ninh Khac, Park, SeonJu, Nhiem, Nguyen Xuan |
| المصدر: | Fitoterapia ; ISSN:1873-6971 ; Volume:177 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Acylated oleanane-type triterpene saponin, Hepatocellular viability, Symplocos cochinchinensis (Lour.) S. Moore, Symplosaponin |
| الوصف: | Four new acylated oleanane-type triterpene saponins, symplosaponins A-D (1-4) were successfully isolated from the leaves of Symplocos cochinchinensis (Lour.) S. Moore, alongside with five known compounds (5-9), 2-methoxy-4-prop-1-enylphenyl-1-O-β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside (5), and 1-[O-β-d-xylopyranosyl-(1 → 6)-O-β-d-glucopyranosyl]-2,6-dimethoxy-4-propenyl-phenol (6), 6-O-p-coumaroylsucrose (7), arillatose B (8), and (-)-secoisolariciresinol-O-β-D-glucopyranoside (9). The structures of these compounds were elucidated through spectroscopic methods, comparison with existing data, and chemical methods. Furthermore, all compounds were assessed for their impact on hepatocellular viability using the Resazurin reduction assay. These investigations aimed to explore the potential hepatoprotective properties of isolated compounds. As a result, 1-[O-β-d-xylopyranosyl-(1 → 6)-O-β-d-glucopyranosyl]-2,6-dimethoxy-4-propenyl-phenol (6) and (-)-secoisolariciresinol-O-β-D-glucopyranoside (9) demonstrated statistically significant hepatoprotective activity in a concentration-dependent manner. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.fitote.2024.106056Test; https://pubmed.ncbi.nlm.nih.gov/38851515Test |
| DOI: | 10.1016/j.fitote.2024.106056 |
| الإتاحة: | https://doi.org/10.1016/j.fitote.2024.106056Test https://pubmed.ncbi.nlm.nih.gov/38851515Test |
| حقوق: | Copyright © 2023. Published by Elsevier B.V. |
| رقم الانضمام: | edsbas.FC449DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.fitote.2024.106056 |
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