دورية أكاديمية
Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase.
| العنوان: | Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. |
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| المؤلفون: | Visalli, Robert J, Ziobrowski, Hannah, Badri, Kameswara R, He, Johnny J, Zhang, Xiugen, Arumugam, Sri Ranjini, Zhao, Hua |
| المصدر: | Bioorg Med Chem Lett ; ISSN:1464-3405 ; Volume:25 ; Issue:16 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2015 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Betulinic acid, HIV-1 reverse transcriptase, Herpes simplex type 2 (HSV-2), Inhibitor |
| الوصف: | Betulinic acid (1) has been modified to ionic derivatives (2-5) to improve its water solubility and biological activities. The binding properties of these derivatives with respect to human serum albumin (HSA) was examined and found to be similar to current anti-HIV drugs. These compounds did not inhibit HIV reverse transcriptase, however, 1, 2 and 5 inhibited herpes simplex type 2 (HSV-2) replication at concentrations similar to those reported for acyclovir (IC50 ∼ 0.1-10 μM) and with minimal cellular cytotoxicity. IC50 values for antiviral activity against HSV-2 186 were 1.6, 0.6, 0.9, 7.2, and 0.9 μM for compounds 1-5, respectively. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.bmcl.2015.05.099Test; https://pubmed.ncbi.nlm.nih.gov/26112446Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494873Test/ |
| DOI: | 10.1016/j.bmcl.2015.05.099 |
| الإتاحة: | https://doi.org/10.1016/j.bmcl.2015.05.099Test https://pubmed.ncbi.nlm.nih.gov/26112446Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494873Test/ |
| حقوق: | Copyright © 2015 Elsevier Ltd. All rights reserved. |
| رقم الانضمام: | edsbas.B6D7A530 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bmcl.2015.05.099 |
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