دورية أكاديمية
Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients
| العنوان: | Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients |
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| المساهمون: | College of Medicine, Dept. of Neurology, Tae-Jin Song, Yoonkyung Chang, Min-Jeong Shin, Ji Hoe Heo, Yong-Jae Kim, Heo, Ji Hoe |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Aged, 80 and over, Asymptomatic Diseases, Brain Ischemia/epidemiology, Brain Ischemia/etiology, Cerebral Infarction/blood, Cerebral Infarction/pathology, Cerebral Infarction/physiopathology, Cerebral Small Vessel Diseases/blood, Cerebral Small Vessel Diseases/pathology, Cerebral Small Vessel Diseases/physiopathology, Cerebrovascular Circulation, Cross-Sectional Studies, Down-Regulation, Fatty Acids, Omega-3/blood, Female, Hospitals, University, Humans, Magnetic Resonance Imaging, Male, Microvessels/pathology, Middle Aged, Prospective Studies, Republic of Korea/epidemiology, Risk Factors, Stroke/epidemiology, Stroke/etiology, Stroke |
| الوصف: | Cerebral small vessel diseases (SVDs) are related to stroke or cognitive dysfunction. n-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent possible disease-modifying factors for cardiovascular disease or dementia. Our hypothesis was that a low proportion of plasma FAs would be associated with cerebral SVDs. We prospectively enrolled 220 patients with a first-episode cerebral infarction within 7 days after symptom onset. The composition of plasma FAs was analyzed by gas chromatography methods. The presence and burden of cerebral microbleeds (CMBs), high-grade white matter changes (HWCs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs) were investigated. The mean proportion (짹 SD) was 2.0 짹 0.7 for EPA, 8.9 짹 1.5 for DHA, and 12.0 짹 2.1 for �닊 n-3-PUFAs. In total, 46 (20.9%) patients had CMBs, 64 (29.1 %) had HWCs, 57 (25.9%) had HPVSs, and 65 (29.5%) had ALIs. In univariate analyses, CMBs, HWCs, and HPVSs were each negatively correlated with the proportion of EPA, DHA, and �닊 n-3-PUFAs. In the multivariate analysis, a lower proportion of EPA, DHA and �닊 n-3-PUFAs was associated with the presence of CMBs, HWCs and HPVS, but not ALIs. Total SVDs score was inversely correlated with the proportion of EPA, DHA and �닊 n-3-PUFAs. Overall, we found an association between low proportions of plasma n-3-PUFAs and cerebral SVDs pathologies. Further studies are needed to explore the association and potential therapeutic role of FAs in cerebral SVDs. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0271-5317 1879-0739 |
| العلاقة: | NUTRITION RESEARCH; J02401; OAK-2015-07488; https://ir.ymlib.yonsei.ac.kr/handle/22282913/157328Test; http://www.sciencedirect.com/science/article/pii/S0271531715000743Test; T201506345; NUTRITION RESEARCH, Vol.35(5) : 368-374, 2015 |
| DOI: | 10.1016/j.nutres.2015.04.008 |
| الإتاحة: | https://doi.org/10.1016/j.nutres.2015.04.008Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/157328Test http://www.sciencedirect.com/science/article/pii/S0271531715000743Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.9309CE08 |
| قاعدة البيانات: | BASE |
| تدمد: | 02715317 18790739 |
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| DOI: | 10.1016/j.nutres.2015.04.008 |