The administration of multipotent stromal cells at precancerous stage precludes tumor growth and epithelial dedifferentiation of oral squamous cell carcinoma
| العنوان: | The administration of multipotent stromal cells at precancerous stage precludes tumor growth and epithelial dedifferentiation of oral squamous cell carcinoma |
|---|---|
| المؤلفون: | Iris Espinoza, Anita Plaza, Paulette Conget, Martha L. Arango-Rodríguez, Flavia Bruna |
| المصدر: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | Elsevier Science, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Cellular differentiation, MULTIPOTENT STROMAL CELLS, Apoptosis, medicine.disease_cause, PRECANCEROUS LESION, 0302 clinical medicine, Cricetinae, Medicine(all), Caspase 3, MESENCHYMAL STEM CELLS, General Medicine, purl.org/becyt/ford/3.1 [https], Medicina Básica, Phenotype, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Disease Progression, Keratins, Female, Mouth Neoplasms, purl.org/becyt/ford/3 [https], Stromal cell, CIENCIAS MÉDICAS Y DE LA SALUD, Inmunología, Down-Regulation, Bone Marrow Cells, PAPILLOMA, Biology, Mesenchymal Stem Cell Transplantation, Immunophenotyping, 03 medical and health sciences, Cytokeratin, Immune system, Cell Line, Tumor, medicine, Animals, Transplantation, Homologous, ORAL SQUAMOUS CELL CARCINOMA, Cell Proliferation, Hyperplasia, Mesocricetus, Papilloma, Mesenchymal stem cell, Histology, Epithelial Cells, Mesenchymal Stem Cells, Cell Biology, Cell Dedifferentiation, medicine.disease, stomatognathic diseases, 030104 developmental biology, Ki-67 Antigen, Immunology, Cancer research, Leukocyte Common Antigens, Carcinogenesis, Transcriptome, Developmental Biology |
| الوصف: | Multipotent stromal cells (MSCs) are envisioned as a powerful therapeutic tool. As they home into tumors, secrete trophic and vasculogenic factors, and suppress immune response their role in carcinogenesis is a matter of controversy. Worldwide oral squamous cell carcinoma (OSCC) is the fifth most common epithelial cancer. Our aim was to determine whether MSC administration at precancerous stage modifies the natural progression of OSCC. OSCC was induced in Syrian hamsters by topical application of DMBA in the buccal pouch. At papilloma stage, the vehicle or 3 × 106 allogenic bone marrow-derived MSCs were locally administered. Four weeks later, the lesions were studied according to: volume, stratification (histology), proliferation (Ki-67), apoptosis (Caspase 3 cleaved), vasculature (ASMA), inflammation (Leukocyte infiltrate), differentiation (CK1 and CK4) and gene expression profile (mRNA). Tumors found in individuals that received MSCs were smaller than those presented in the vehicle group (87 ± 80 versus 54 ± 62 mm3, p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919ef5722a58a2fb35613fdcf5004e84Test https://www.sciencedirect.com/science/article/pii/S1873506116301908Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....919ef5722a58a2fb35613fdcf5004e84 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |