دورية أكاديمية
MAIT cells activate dendritic cells to promote T
| العنوان: | MAIT cells activate dendritic cells to promote T |
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| المؤلفون: | Pankhurst, Theresa E, Buick, Kaitlin H, Lange, Joshua L, Marshall, Andrew J, Button, Kaileen R, Palmer, Olga R, Farrand, Kathryn J, Montgomerie, Isabelle, Bird, Thomas W, Mason, Ngarangi C, Kuang, Joanna, Compton, Benjamin J, Comoletti, Davide, Salio, Mariolina, Cerundolo, Vincenzo, Quiñones-Mateu, Miguel E, Painter, Gavin F, Hermans, Ian F, Connor, Lisa M |
| المصدر: | Cell Rep ; ISSN:2211-1247 ; Volume:42 ; Issue:4 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2023 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | CP: Immunology, IgA, MAIT cell, SARS-CoV-2, T(FH) cell, adjuvant, dendritic cell, humoral immunity, influenza, mucosal vaccine |
| الوصف: | Protective immune responses against respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal immune system. However, most licensed vaccines are administered parenterally and are largely ineffective at inducing mucosal immunity. The development of safe and effective mucosal vaccines has been hampered by the lack of a suitable mucosal adjuvant. In this study we explore a class of adjuvant that harnesses mucosal-associated invariant T (MAIT) cells. We show evidence that intranasal immunization of MAIT cell agonists co-administered with protein, including the spike receptor binding domain from SARS-CoV-2 virus and hemagglutinin from influenza virus, induce protective humoral immunity and immunoglobulin A production. MAIT cell adjuvant activity is mediated by CD40L-dependent activation of dendritic cells and subsequent priming of T follicular helper cells. In summary, we show that MAIT cells are promising vaccine targets that can be utilized as cellular adjuvants in mucosal vaccines. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.celrep.2023.112310Test; https://pubmed.ncbi.nlm.nih.gov/36989114Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045373Test/ |
| DOI: | 10.1016/j.celrep.2023.112310 |
| الإتاحة: | https://doi.org/10.1016/j.celrep.2023.112310Test https://pubmed.ncbi.nlm.nih.gov/36989114Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045373Test/ |
| حقوق: | Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.D98D9531 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2023.112310 |
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