دورية أكاديمية

First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: An open-label, randomised phase 2/3 trial

التفاصيل البيبلوغرافية
العنوان: First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: An open-label, randomised phase 2/3 trial
المؤلفون: Harrison L., Babiker A., Castro H., Compagnucci A., Fiscus S., Giaquinto C., Gibb D. M., Harper L., Hughes M., McKinney R., Melvin A., Mofenson L., Saidi Y., Smith M. E., Tudor-Williams G., Walker A. S., Brouwers P., Costello D., Ferguson E., Hodge J., Jennings C., Warshaw M., Spector S., Stiehm E., Toye M., Yogev R., Aboulker J. P., De Rossi A., Darbyshire J., Debre M., Klein N., Pillay D., Brody B., Hill C., Lepage P., Modlin J., Poziak A., Rein M., Robb M., Fleming T., Vella S., Kim K. M., Bologna R., Mecikovsky D., Pineda N., Sen L., Mangano A., Marino S., Galvez C., Deluchi G., Zohrer B., Zenz W., Daghofer E., Pfurtscheller K., Pabst B., Gomez M. P., McNeil P., Jervis M., Whyms I., Kwolfe D., Scott S., Mussi-Pinhata M. M., Issac M. L., Cervi M. C., Negrini B. V. M., Matsubara T. C., de Souza C. B. S. S., Gabaldi J. C., Oliveira R. H., Sapia M. C., Abreu T., Evangelista L., Pala A., Fernandes I., Farias I., Melo M. F., Carreira H., Lira L. M., della Negra M., Queiroz W., Lian Y. C., Pacola D. P., Pinto J., Ferreira F., Kakehasi F., Martins L., Diniz A., Lobato V., Diniz M., Cleto S., Costa S., Romeiro J., Dollfus C., Tabone M. D., Courcoux M. F., Vaudre G., Dehee A., Schnuriger A., Le Gueyades N., De Bortoli C., Mechinaud F., Reliquet V., Arias J., Rodallec A., Andre E., Falconi I., Le Pelletier A., Monpoux F., Cottalorda J., Mellul S., Lachassinne E., Galimand J., Rouzioux C., Chaix M. L., Benabadji Z., Pourrat M., Firtion G., Rivaux D., Denon M., Boudjoudi N., Nganzali F., Krivine A., Meritet J. F., Delommois G., Norgeux C., Guerin C., Floch C., Marty L., Hichou H., Tournier V., Faye A., Le Moal I., Sellier M., Dehache L., Damond F., Leleu J., Beniken D., Alexandre-Castor G., Neubert J., Niehues T., Laws H. J., Huck K., Gudowius S., Loeffler H., Bellert S., Ortwin A., Notheis G., Wintergerst U., Hoffman F., Werthmann A., Seyboldt S., Schneider L., Bucholz B., Feiterna-Sperling C., Peiser C., Nickel R., Schmitz T., Piening T., Muller C., Warncke G., Wigger M., Neubauer R., Butler K., Chang A. L., Belger T., Menon A., O'connell M., Barrett L., Rochford A., Goode M., Hayes E., McDonagy S., Walsh A., Doyle A., Fanning J., O'connor M., Byrne M., O'sullivan N., Hyland E., Giacomet V., Vigano A., Colombo I., Trabattoni D., Berzi A., Badolato R., Schumacher F., Bennato V., Brusati M., Sorlini A., Spinelli E., Filisetti M., Bertulli C., Rampon O., Zanchetta M., Mazza A., Stringari G., Rossetti G., Bernardi S., Martino A., Castelli Gattinara G., Palma P., Pontrelli G., Tchidjou H., Furcas A., Frillici C., Mazzei A., Zoccano A., Concato C., Duiculescu D., Oprea C., Tardei G., Abaab F., Mardarescu M., Draghicenoiu R., Otelea D., Alecsandru L., Matusa R., Rugina S., Ilie M., Netescu S., Florea C., Voicu E., Poalelungi D., Belmega C., Vladau L., Ramos Amador J. T., Gonzalez Tome M. I., Rojo Conejo P., Fernandez M., Delgado Garcia R., Ferrari J. M., Garcia Lopez M., Mellado Pena M. J., Martin Fontelos P., Jimenez Nacher I., Munoz Fernandez M. A., Jimenez J. L., Garcia Torre A., Penin M., Pineiro Perez R., Garcia Mellado I., Finn A., Lajeunesse M., Hutchison E., Usher J., Ball L., Dunn M., Sharland M., Doerholt K., Storey S., Donaghy S., Wells C., Buckberry K., Rice P., McMaster P., Butler P., Farmer C., Shenton J., Haley H., Orendi J., Stroobant J., Navarante L., Archer P., Mazhude C., Scott D., O'connell R., Wong J., Boddy G., Shackley F., Lakshman R., Hobbs J., Ball G., Kudesia G., Bane J., Painter D., Sloper K., Shah V., Cheng A., Aali A., Ball C., Hawkins S., Nayagam D., Waters A., Doshi S., Liebeschuetz S., Sodiende B., Shingadia D., Wong S., Swan J., Shah Z., Collinson A., Hayes C., King J., O'connor K., Lyall H., Fidler K., Walters S., Foster C., Hamadache D., Newbould C., Monrose C., Campbell S., Yeung S., Cohen J., Martinez-Allier N., Melvin D., Dodge J., Welch S., Tatum G., Gordon A., Kaye S., Muir D., Patel D., Novelli V., Gibb D., Moshal K., Lambert J., Flynn J., Farrelly L., Clapson M., Spencer L., Depala M., Jacobsen M., Segal S., Pollard A., Yeadon S., Peng Y., Dong T., Jeffries K., Snelling M., Smyth A., Smith J., Ward B., Jungmann E., Ryan C., Swaby K., Buckton A., Smidt E., Abrams E. J., Champion S., Fernandez A. D., Calo D., Garrovillo L., Swaminathan K., Alford T., Frere M., Navarra J., Borkowsky W., Deygoo S., Hastings T., Akleh S., Ilmet T., Mohan K., Bowen G., Emmanuel P. J., Lujan-Zimmerman J., Rodriguez C., Johnson S., Marion A., Graisbery C., Casey D., Lewis G., Guzman-Cottrill J., Croteau R., Acevedo-Flores M., Gonzalez M., Angeli L., Fabregas L., Valentin P., Weiner L., Contello K. A., Holz W., Butler M., Nachman S., Kelly M. A., Ferraro D. M., Rana S., Reed C., Yeagley E., Malheiro A., Roa J., Neely M., Kovacs A., Homans J., Rodriguez Lozano Y., Puga A., Talero G., Sellers R., Lawrence R., Weinberg G. A., Murante B., Laverty S., Deveikis A., Batra J., Chen T., Michalik D., Deville J., Elkins K., Marks S., Jackson Alvarez J., Palm J., Fineanganofo I., Keuth M., Deveikis L., Tomosada W., Van Dyke R., Alchediak T., Silio M., Borne C., Bradford S., Eloby-Childress S., Nguyen K., Rathore M. H., Alvarez A., Mirza A., Mahmoudi S., Burke M., Febo I. L., Lugo L., Santos R., Church J. A., Dunaway T., Rodier C., Flynn P., Patel N., Discenza S., Donohoe M., Luzuriaga K., Picard D., Kline M., Paul M. E., Shearer W. T., McMullen-Jackson C., Chadwick E., Cagwin E., Kabat K., Dieudonne A., Palumbo P., Johnson J., Gaur S., Cerracchio L., Foca M., Jurgrau A., Vasquez Bonilla S., Silva G., Gershon A., Sullivan J., Bryson Y., Frenkel L., Nelson J., Hadjou G., Leonardo S., Riault Y., Buck L., Darbyshire J. H., Forcat S., Horton J., Johnson D., Moore S., Taylor C., Collins D., Buskirk S., Kamara P., Nesel C., Johnson M., Ferreira A., Tutko J., Sprenger H., Britto P., Powell C., Dersimonian R., Handelsman E., Ananworanich J., Belfrage E., Blanche S., Bohlin A. B., Burger D., Castelli-Gattinara G., Clayden P., De Groot R., Grosch-Worner I., Lallemant M., Levy J., Marczynska M., Nadal D., Peckham C., Rosado L., Rosso R., Rudin C., Scherpbier H., Stevanovic M., Thorne C., Tovo P. A., Valerius N.
المساهمون: Harrison, L, Babiker, A, Castro, H, Compagnucci, A, Fiscus, S, Giaquinto, C, Gibb, Dm, Harper, L, Hughes, M, Mckinney, R, Melvin, A, Mofenson, L, Saidi, Y, Smith, Me, Tudor-Williams, G, Walker, A, Brouwers, P, Costello, D, Ferguson, E, Hodge, J, Jennings, C, Warshaw, M, Spector, S, Stiehm, E, Toye, M, Yogev, R, Aboulker, Jp, De Rossi, A, Darbyshire, J, Debre, M, Klein, N, Pillay, D, Brody, B, Hill, C, Lepage, P, Modlin, J, Poziak, A, Rein, M, Robb, M, Fleming, T, Vella, S, Kim, Km, Bologna, R, Mecikovsky, D, Pineda, N, Sen, L, Mangano, A, Marino, S, Galvez, C, Deluchi, G, Zohrer, B, Zenz, W, Daghofer, E, Pfurtscheller, K, Pabst, B, Gomez, Mp, Mcneil, P, Jervis, M, Whyms, I, Kwolfe, D, Scott, S, Mussi-Pinhata, Mm, Issac, Ml, Cervi, Mc, Negrini, Bvm, Matsubara, Tc, de Souza, Cb, Gabaldi, Jc, Oliveira, Rh, Sapia, Mc, Abreu, T, Evangelista, L, Pala, A, Fernandes, I, Farias, I, Melo, Mf, Carreira, H, Lira, Lm, della Negra, M, Queiroz, W, Lian, Yc, Pacola, Dp, Pinto, J, Ferreira, F, Kakehasi, F, Martins, L, Diniz, A, Lobato, V, Diniz, M, Cleto, S, Costa, S, Romeiro, J, Dollfus, C, Tabone, Md, Courcoux, Mf, Vaudre, G, Dehee, A, Schnuriger, A, Le Gueyades, N, De Bortoli, C
بيانات النشر: ELSEVIER SCI LTD
سنة النشر: 2011
المجموعة: Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca
مصطلحات موضوعية: Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
الوصف: Background Children with HIV will be on antiretroviral therapy (ART) longer than adults, and therefore the durability of first-line ART and timing of switch to second-line are key questions. We assess the long-term outcome of protease inhibitor and non-nucleoside reverse transcriptase inhibitor (NNRTI) first-line ART and viral load switch criteria in children.Methods In a randomised open-label factorial trial, we compared effectiveness of two nucleoside reverse transcriptase inhibitors (NRTIs) plus a protease inhibitor versus two NRTIs plus an NNRTI and of switch to second-line ART at a viral load of 1000 copies per mL versus 30 000 copies per mL in previously untreated children infected with HIV from Europe and North and South America. Random assignment was by computer-generated sequentially numbered lists stratified by age, region, and by exposure to perinatal ART Primary outcome was change in viral load between baseline and 4 years. Analysis was by intention to treat, which we defined as all patients that started treatment. This study is registered with ISRCTN, number ISRCTN73318385.Findings Between Sept 25,2002, and Sept 7,2005,266 children (median age 6.5 years; IQR 2.8-12-9) were randomly assigned treatment regimens: 66 to receive protease inhibitor and switch to second-line at 1000 copies per mL (PI-low), 65 protease inhibitor and switch at 30 000 copies per mL (PI-higher), 68 NNRTI and switch at 1000 copies per mL (NNRTI-low), and 67 NNRTI and switch at 30000 copies per mL (NNRTI-higher). Median follow-up was 5.0 years (IQR 4.2-6.0) and 188 (71%) children were on first-line ART at trial end. At 4 years, mean reductions in viral load were -3.16 log(10) copies per mL for protease inhibitors versus -3.31 log(10) copies per mL for NNRTIs (difference -0.15 log(10) copies per mL, 95% CI -0.41 to 0.11; p=0.26), and 3.26 log(10) copies per mL for switching at the low versus 3.20 log(10) copies per mL for switching at the higher threshold (difference 0.06 log,o copies per mL, 95% CI -0.20 to 0.32; p=0.56). ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000289275600015; volume:11; issue:4; firstpage:273; lastpage:283; numberofpages:11; journal:THE LANCET INFECTIOUS DISEASES; http://hdl.handle.net/2108/281582Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79953054005
DOI: 10.1016/S1473-3099(10)70313-3
الإتاحة: https://doi.org/10.1016/S1473-3099Test(10)70313-3
http://hdl.handle.net/2108/281582Test
رقم الانضمام: edsbas.1C27E5D4
قاعدة البيانات: BASE