دورية أكاديمية
Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 omicron infection and related hospital admission among people with substance use disorder in Hong Kong: a matched case-control study
| العنوان: | Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 omicron infection and related hospital admission among people with substance use disorder in Hong Kong: a matched case-control study |
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| المؤلفون: | Huang, Caige, Wei, Yue, Yan, Vincent KC, Ye, Xuxiao, Kang, Wei, Yiu, Hei Hang Edmund, Shami, Jessica JP, Cowling, Benjamin J, Tse, Man Li, Castle, David J, Chui, Celine SL, Lai, Francisco TT, Li, Xue, Wan, Eric YF, Wong, Carlos KH, Hayes, Joseph F, Chang, Wing Chung, Chung, Albert KK, Lau, Chak Sing, Wong, Ian CK, Chan, Esther W |
| المصدر: | The Lancet Psychiatry , 10 (6) pp. 403-413. (2023) |
| بيانات النشر: | ELSEVIER SCI LTD |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | BACKGROUND: People with substance use disorder have a high risk of SARS-CoV-2 infection and subsequent poor outcomes. Few studies have evaluated COVID-19 vaccine effectiveness among people with substance use disorder. We aimed to estimate the vaccine effectiveness of BNT162b2 (Fosun-BioNTech) and CoronaVac (Sinovac) against SARS-CoV-2 omicron (B.1.1.529) infection and related hospital admission in this population. // METHODS: We did a matched case-control study using electronic health databases in Hong Kong. Individuals diagnosed with substance use disorder between Jan 1, 2016, and Jan 1, 2022, were identified. People aged 18 years and older with SARS-CoV-2 infection from Jan 1 to May 31, 2022, and people with COVID-19-related hospital admission from Feb 16 to May 31, 2022, were included as cases and were matched by age, sex, and previous clinical history with controls from all individuals diagnosed with substance use disorder who attended the Hospital Authority health services: up to three controls for SARS-CoV-2 infection and up to ten controls for hospital admission. Conditional logistical regression was used to evaluate the association between vaccination status (ie, one, two, or three doses of BNT162b2 or CoronaVac) and the risk of SARS-CoV-2 infection and COVID-19-related hospital admission, adjusted for baseline comorbidities and medication use. // FINDINGS: Among 57 674 individuals with substance use disorder, 9523 people with SARS-CoV-2 infections (mean age 61·00 years, SD 14·90; 8075 [84·8%] males and 1448 [15·2%] females) were identified and matched to 28 217 controls (mean age 60·99 years, 14·67; 24 006 [85·1%] males and 4211 [14·9%] females), and 843 people with COVID-19-related hospital admissions (mean age 70·48 years, SD 14·68; 754 [89·4%] males and 89 [10·6%] females) were identified and matched to 7459 controls (mean age 70·24 years, 13·87; 6837 [91·7%] males and 622 [8·3%] females). Data on ethnicity were not available. We observed significant vaccine effectiveness against SARS-CoV-2 infection ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10183570/1/Vaccine%20effectiveness%20of%20BNT162b2%20and%20CoronaVac%20against%20SARS-CoV-2%20omicron%20infection%20and%20related%20hospital%20admission%20among%20pe.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10183570Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10183570/1/Vaccine%20effectiveness%20of%20BNT162b2%20and%20CoronaVac%20against%20SARS-CoV-2%20omicron%20infection%20and%20related%20hospital%20admission%20among%20pe.pdfTest https://discovery.ucl.ac.uk/id/eprint/10183570Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.FECED40D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |