Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study
| العنوان: | Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study |
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| المؤلفون: | Alet H. Wijga, Isabella Annesi-Maesano, Gerard H. Koppelman, Stefano Guerra, Cynthia Hohmann, Marta Benet, Magnus Wickman, Josep M. Antó, Andrea von Berg, Jordi Sunyer, Ulrike Gehring, Jean Bousquet, Karin C. Lødrup Carlsen, Joachim Heinrich, Esben Eller, Jocelyne Just, Dietrich Berdel, Isabelle Momas, Carsten Bindslev-Jensen, Henriette A. Smit, Manolis Kogevinas, Renato T. Stein, Inger Kull, Marjan Kerkhof, Thomas Keil, Kai-Håkon Carlsen, Xavier Basagaña, Erik Melén, Dirkje S. Postma, Maties Torrent, Daniela Porta, Maria Pia Fantini, Jacopo Lenzi, Susanne Lau, Sibylle Koletzko, Fanny Rancière, Judith Garcia-Aymerich, Mariona Pinart, Christina Tischer |
| المساهمون: | Physical Geography Research Institute, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Groningen Research Institute for Asthma and COPD (GRIAC), Pinart M, Benet M, Annesi-Maesano I, von Berg A, Berdel D, Carlsen KC, Carlsen KH, Bindslev-Jensen C, Eller E, Fantini MP, Lenzi J, Gehring U, Heinrich J, Hohmann C, Just J, Keil T, Kerkhof M, Kogevinas M, Koletzko S, Koppelman GH, Kull I, Lau S, Melén E, Momas I, Porta D, Postma DS, Rancière F, Smit HA, Stein RT, Tischer CG, Torrent M, Wickman M, Wijga AH, Bousquet J, Sunyer J, Basagaña X, Guerra S, Garcia-Aymerich J, Antó JM |
| المصدر: | The Lancet Respiratory Medicine; Vol 2 Pinart, M, Benet, M, Annesi-Maesano, I, von Berg, A, Berdel, D, Carlsen, K C L, Carlsen, K-H, Bindslev-Jensen, C, Eller, E, Fantini, M P, Lenzi, J, Gehring, U, Heinrich, J, Hohmann, C, Just, J, Keil, T, Kerkhof, M, Kogevinas, M, Koletzko, S, Koppelman, G H, Kull, I, Lau, S, Melén, E, Momas, I, Porta, D, Postma, D S, Rancière, F, Smit, H A, Stein, R T, Tischer, C G, Torrent, M, Wickman, M, Wijga, A H, Bousquet, J, Sunyer, J, Basagaña, X, Guerra, S, Garcia-Aymerich, J & Antó, J M 2014, ' Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL : a population-based cohort study ', The Lancet Respiratory Medicine, vol. 2, no. 2, pp. 131-140 . https://doi.org/10.1016/S2213-2600Test(13)70277-7 The Lancet Respiratory Medicine, 2(2), 131. Elsevier Limited The Lancet. Respiratory Medicine, 2(2), 131-140. ELSEVIER SCI LTD |
| بيانات النشر: | ELSEVIER SCI LTD, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | CHILDHOOD ISAAC, Male, Questionnaires, Pediatrics, Allergy, Cross-sectional study, Eczema, CHILDREN, Disease, Comorbidity, Immunoglobulin E, 0302 clinical medicine, Surveys and Questionnaires, Prevalence, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Child, Rhinitis, biology, ASSOCIATION, PREVALENCE, ALLERGIC RHINITIS, Europe, rhiniti, DISEASES, Child, Preschool, Female, eczema, Pulmonary and Respiratory Medicine, Risk, medicine.medical_specialty, DISORDERS, PHENOTYPES, MECHANISMS, 03 medical and health sciences, AGE, medicine, Humans, Immunologic Factors, PROSPECTIVE BIRTH COHORT, Asthma, business.industry, medicine.disease, Cross-Sectional Studies, 030228 respiratory system, Relative risk, biology.protein, Linear Models, ASTHMA, COMORBIDITY, business, Follow-Up Studies |
| الوصف: | Summary Background Eczema, rhinitis, and asthma often coexist (comorbidity) in children, but the proportion of comorbidity not attributable to either chance or the role of IgE sensitisation is unknown. We assessed these factors in children aged 4–8 years. Methods In this prospective cohort study, we assessed children from 12 ongoing European birth cohort studies participating in MeDALL (Mechanisms of the Development of ALLergy). We recorded current eczema, rhinitis, and asthma from questionnaires and serum-specific IgE to six allergens. Comorbidity of eczema, rhinitis, and asthma was defined as coexistence of two or three diseases in the same child. We estimated relative and absolute excess comorbidity by comparing observed and expected occurrence of diseases at 4 years and 8 years. We did a longitudinal analysis using log-linear models of the relation between disease at age 4 years and comorbidity at age 8 years. Findings We assessed 16 147 children aged 4 years and 11 080 aged 8 years in cross-sectional analyses. The absolute excess of any comorbidity was 1·6% for children aged 4 years and 2·2% for children aged 8 years; 44% of the observed comorbidity at age 4 years and 50·0% at age 8 years was not a result of chance. Children with comorbidities at 4 years had an increased risk of having comorbidity at 8 years. The relative risk of any cormorbidity at age 8 years ranged from 36·2 (95% CI 26·8–48·8) for children with rhinitis and eczema at age 4 years to 63·5 (95% CI 51·7–78·1) for children with asthma, rhinitis, and eczema at age 4 years. We did longitudinal assessment of 10 107 children with data at both ages. Children with comorbidities at 4 years without IgE sensitisation had higher relative risks of comorbidity at 8 years than did children who were sensitised to IgE. For children without comorbidity at age 4 years, 38% of the comorbidity at age 8 years was attributable to the presence of IgE sensitisation at age 4 years. Interpretation Coexistence of eczema, rhinitis, and asthma in the same child is more common than expected by chance alone—both in the presence and absence of IgE sensitisation—suggesting that these diseases share causal mechanisms. Although IgE sensitisation is independently associated with excess comorbidity of eczema, rhinitis, and asthma, its presence accounted only for 38% of comorbidity, suggesting that IgE sensitisation can no longer be considered the dominant causal mechanism of comorbidity for these diseases. Funding EU Seventh Framework Programme. |
| وصف الملف: | application/pdf; ELETTRONICO |
| اللغة: | English |
| تدمد: | 2213-2600 |
| DOI: | 10.1016/S2213-2600(13)70277-7 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45378aff6f015dda011a91a9e297db79Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....45378aff6f015dda011a91a9e297db79 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22132600 |
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| DOI: | 10.1016/S2213-2600(13)70277-7 |