التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective alpha 1D-adrenergic receptor ligand |
| المؤلفون: |
McGinty, Susan J., Finch, Angela, Griffith, Renate, Graham, Robert M., Bremmer, John B. |
| المساهمون: |
The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Science |
| بيانات النشر: |
Elsevier Ltd. |
| سنة النشر: |
2004 |
| المجموعة: |
NOVA: The University of Newcastle Research Online (Australia) |
| مصطلحات موضوعية: |
α₁-adrenergic receptor, 6β-hydroxytropinone, 3,6,6-trisubstituted nortropanes, microwave assisted reactions |
| الوصف: |
A range of 3,6,6-trisubstituted nortropane derivatives based upon 6β-phenyltropane-3β,6 α-diol have been synthesised from 6β-hydroxytropinone, including some novel related tricyclic hemi-ketal and tricyclic ketal compounds. Derivatives were assessed for pharmacological affinity and selectivity at α₁-adrenergic receptors, and 6β-phenyl-8-azabicyclo[3.2.1]octan-3-spiro-2'-(1',3'-dioxolane)-6-ol, a novel lead compound selective for the alpha₁D-adrenergic receptor, is reported. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0968-0896 |
| العلاقة: |
Bioorganic and Medicinal Chemistry Vol. 12, Issue 21, p. 5639-5650; http://hdl.handle.net/1959.13/33971Test; uon:3428 |
| الإتاحة: |
http://hdl.handle.net/1959.13/33971Test |
| رقم الانضمام: |
edsbas.33EE172D |
| قاعدة البيانات: |
BASE |
