Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses
| العنوان: | Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses |
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| المؤلفون: | Gary Wong, Alexander Lai, Yuhai Bi, George F. Gao, Shuo Su, Weifeng Shi, Jiyong Zhou, Wenjun Liu, Jun Liu |
| المصدر: | Trends in Microbiology |
| بيانات النشر: | Elsevier Ltd., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Deltacoronavirus, coronavirus, medicine.disease_cause, Microbiology, Communicable Diseases, Emerging, Article, Pathogenesis, 03 medical and health sciences, MERS, Virology, Epidemiology, evolution, medicine, Humans, Coronavirus, SARS, Recombination, Genetic, biology, SARS-CoV-2, pathogenesis, Outbreak, virus diseases, COVID-19, Common cold, biology.organism_classification, medicine.disease, recombination, 030104 developmental biology, Infectious Diseases, Viral evolution, Immunology, Middle East respiratory syndrome |
| الوصف: | Human coronaviruses (HCoVs) were first described in the 1960s for patients with the common cold. Since then, more HCoVs have been discovered, including those that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), two pathogens that, upon infection, can cause fatal respiratory disease in humans. It was recently discovered that dromedary camels in Saudi Arabia harbor three different HCoV species, including a dominant MERS HCoV lineage that was responsible for the outbreaks in the Middle East and South Korea during 2015. In this review we aim to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans. Trends Six coronaviruses (CoVs) are known to infect humans: 229E, OC43, SARS-CoV, NL63, HKU1, and MERS-CoV. Many CoVs are simultaneously maintained in nature, allowing for genetic recombination, resulting in novel viruses. Recombination of CoV in camels has resulted in a dominant MERS lineage that caused human outbreaks in 2015. |
| اللغة: | English |
| تدمد: | 1878-4380 0966-842X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d933c130867a54c1f5ffcf93feaee1Test http://europepmc.org/articles/PMC7125511Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f5d933c130867a54c1f5ffcf93feaee1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18784380 0966842X |
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