دورية أكاديمية
In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs
| العنوان: | In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs |
|---|---|
| المؤلفون: | Skinner, Tina S., Manning, Linda S., Johnston, Wayne A., Davis, Timothy M.E. |
| المصدر: | International Journal for Parasitology |
| بيانات النشر: | Elsevier Ltd. |
| سنة النشر: | 1996 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | artemisinin drugs, chloroquine, malaria, Plasmodium falciparum, quinine, Stage-specific sensitivity |
| الوصف: | The inhibitory effects of quinine, chloroquine and 4 qinghaosu drugs, artemisinin, artemether, artesunate and dihydroartemisinin, on 4 culture- adapted isolates and 2 standard clones of Plasmodium falciparum were determined in vitro. All isolates were sensitive to the widely used antimalarial drugs quinine (EC 50 range 3 x 10 -8 -1 x 10 -7 mol/L) and chloroquine (EC 50 range 1 x 10 -9 -7 x 10 -9 mol/L), irrespective of the geographical origin or treatment history of the patients from which they were taken. In general, the qinghaosu drugs were more potent than the conventional antimalarials, having EC 50 values of 3 x 10 -11 -3 x 10 -8 mol/L. Stage- specific data indicated that quinine has a primary mode of action on mature parasite forms, achieving 80-100% growth inhibition within 2-4 h of drug exposure. The stage-specific activity of the 3 qinghaosu drugs artemisinin, artemether and dihydroartemisinin differed from that of quinine, and each derivative displayed a unique stage-specific profile. Artemisinin was rapidly effective against both rings and schizonts, achieving 100% growth inhibition within 6-8 h. The inhibitory effects of artemether were less rapid, requiring 10 h to achieve 70-80% ring stage growth inhibition. Dihydroartemisinin was highly effective against all parasite stages, in most cases achieving 100% growth inhibition within 2-4 h of exposure. The results confirm that the qinghaosu drugs are potent antimalarials, and suggest different stage- specific profiles compared to conventional antimalarial drugs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Skinner, Tina S., Manning, Linda S., Johnston, Wayne A., & Davis, Timothy M.E. (1996) In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs. International Journal for Parasitology, 26(5), pp. 519-525.; https://eprints.qut.edu.au/241613Test/ |
| الإتاحة: | https://doi.org/10.1016/0020-7519Test(96)89380-5 https://eprints.qut.edu.au/241613Test/ |
| رقم الانضمام: | edsbas.91F9BE26 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |