Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-tau181P
| العنوان: | Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-tau181P |
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| المؤلفون: | Jean Jacques Martin, K Koopman, Peter Paul De Deyn, Sebastiaan Engelborghs, Nathalie Le Bastard, Guy Nagels |
| المساهمون: | Internal Medicine Specializations, Clinical sciences, Neurology, Faculty of Engineering, Neuroprotection & Neuromodulation |
| المصدر: | Vrije Universiteit Brussel Neurochemistry international Neurochemistry International, 55(4), 214-218. PERGAMON-ELSEVIER SCIENCE LTD |
| بيانات النشر: | Elsevier Limited, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Threonine, Pathology, MILD COGNITIVE IMPAIRMENT, Plaque, Amyloid, CLINICAL-DIAGNOSIS, Degenerative disease, Cerebrospinal fluid, MARKERS, Catalytic Domain, Phosphorylation, Aged, 80 and over, biology, Research Support, Non-U.S. Gov't, Brain, Neurofibrillary Tangles, Alzheimer's disease, Chemistry, Female, Autopsy, Psychology, PHOSPHORYLATED-TAU, Frontotemporal dementia, medicine.medical_specialty, Tau protein, tau Proteins, Sensitivity and Specificity, cerebrospinal fluid, Central nervous system disease, Diagnosis, Differential, Cellular and Molecular Neuroscience, CEREBROSPINAL-FLUID, Alzheimer Disease, Predictive Value of Tests, mental disorders, Journal Article, medicine, Dementia, Humans, Amino Acid Sequence, Hyperphosphorylated tau, Aged, Amyloid beta-Peptides, Dementia with Lewy bodies, biomarkers, Cell Biology, PERFORMANCE, medicine.disease, Peptide Fragments, biology.protein, Human medicine, dementia |
| الوصف: | To establish diagnostic accuracy (acc) and optimal cut-off levels of CSF tau phosphorylated at threonine 181 (P-tau(181P)) for discriminating Alzheimer's disease (AD) from non-AD dementias in autopsy-confirmed dementia patients, CSF levels of beta-amyloid peptide (A beta(1-42)). total tau protein (T-tau) and P-tau(181P) from patients with definite AD (n=95) and non-AD demential (n=50) were determined with single-parameter ELISA kits. Optimal P-tau(181P) cut-off levels for differentiating AD from pooled non-AD demential, dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) were 50.4 pg/mL (acc = 0.73), 52.8 pg/mL (acc = 0.73) and 35.3 pg/mL (acc = 0.90), respectively.The optimal CSF P-tau(181P) cut-off level for discriminating AD from non-AD demential was 50.4 pg/mL. Optimal CSF P-tau(181P) cut-off levels differed between non-AD diagnostic dementia categories. (C) 2009 Elsevier Ltd. All rights reserved. |
| وصف الملف: | |
| اللغة: | English |
| تدمد: | 0197-0186 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c74873e938e64e5d76ef525cb50e63Test https://biblio.vub.ac.be/vubir/improved-discrimination-of-autopsyconfirmed-alzheimers-disease-ad-from-nonad-dementias-using-csf-ptau181pTest(97c5e850-dd4f-4745-b9a9-ec353839e93e).html |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....73c74873e938e64e5d76ef525cb50e63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01970186 |
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