دورية أكاديمية
In vivo and ex vivo proton MR spectroscopy of primary and secondary melanoma
| العنوان: | In vivo and ex vivo proton MR spectroscopy of primary and secondary melanoma |
|---|---|
| المؤلفون: | Bourne, Roger M., Stanwell, Peter, Stretch, Jonathan R., Scolyer, Richard A., Thompson, John F., Mountford, Carolyn E., Lean, Cynthia L. |
| المصدر: | European Journal of Radiology |
| بيانات النشر: | Elsevier Ireland Ltd. |
| سنة النشر: | 2005 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Magnetic resonance spectroscopy, Melanoma, Cancer, Lymph nodes, Skin, Metastases |
| الوصف: | In vivo magnetic resonance (MR) spectroscopy at 1.5T was performed on a large polypoid cutaneous melanoma, and two enlarged lymph nodes containing metastatic melanoma, from three patients. Spectra were acquired in vivo from voxels wholly within the primary tumour or secondary lymph node and were thus uncontaminated by signals from adjacent tissue. Tissue biopsies taken after resection of primary tumours and secondary lymph nodes were examined by 8.5T magnetic resonance spectroscopy (MRS) and the results compared with the in vivo spectra, and with spectra from normal skin and a benign skin lesion. There was good agreement between the dominant features of 1.5T spectra acquired in vivo and 8.5T spectra acquired from resected tissue. However, less intense resonances observed at 8.5T in malignant biopsy tissue were not consistently observed at 1.5T in vivo. In vivo spectra from primary and metastatic melanoma showed high levels of choline metabolites. An intense lactate resonance was also present in the in vivo spectrum of primary melanoma. All 8.5T spectra of biopsies from primary and secondary melanoma showed high levels of choline metabolites and lactate, and additional resonances consistent with elevated levels of taurine, alanine, lysine, and glutamate/glutamine relative to normal and benign tissue. Elevated levels of choline, lactate, taurine, and amino acids appear to be clinically useful markers for identifying the pathology of primary and metastatic melanoma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Bourne, Roger M., Stanwell, Peter, Stretch, Jonathan R., Scolyer, Richard A., Thompson, John F., Mountford, Carolyn E., & Lean, Cynthia L. (2005) In vivo and ex vivo proton MR spectroscopy of primary and secondary melanoma. European Journal of Radiology, 53(3), pp. 506-513.; https://eprints.qut.edu.au/111659Test/; Faculty of Health |
| الإتاحة: | https://doi.org/10.1016/j.ejrad.2004.03.016Test https://eprints.qut.edu.au/111659Test/ |
| حقوق: | Copyright 2004 Elsevier Ireland ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.5B346FE2 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |