Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases
| العنوان: | Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases |
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| المؤلفون: | Raffaele Ferri, Susanna Lopez, Lutfu Hanoglu, Lucia Fraioli, Ute Gschwandtner, Francesco Orzi, Görsev Yener, Marco Onofrj, Gerhard Ransmayr, Laura Vacca, John-Paul Taylor, Raffaella Franciotti, Laura Bonanni, Bahar Güntekin, Andrea Soricelli, Michela Pievani, Giovanni B. Frisoni, Francesco Famà, Fabrizia D'Antonio, Peter Fuhr, Roberta Lizio, Giuseppe Noce, Maria Francesca De Pandis, Dario Arnaldi, Valentina Catania, Carlo de Lena, Antonio Ivano Triggiani, Flavio Nobili, Claudio Babiloni, Claudio Del Percio, Paola Stirpe, Erol Başar, Fabrizio Stocchi, Maria Teresa Pascarelli, Heinrich Garn, Derya Durusu Emek-Savaş, Franco Giubilei, Carla Buttinelli |
| المساهمون: | Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Ple A Moro 5, I-00185 Rome, Italy, Stirpe, Paola, Stocchi, Fabrizio IRCCS San Raffaele Pisana Roma & Cassino, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neurosci DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS AOU S Martino IST, Genoa, Italy, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Onofrj, Marco Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Petersgraben 4, CH-4031 Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Neurol 2, Med Campus 3,Krankenhausstr 9, A-4020 Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, Italy, Pievanim, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, D'Antonio, Fabrizia, De Lena, Carlo Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Basar, Erol, Yener, Gorsev, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, Med Sch, Dept Neurol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, England, Vacca, Laura CCPP Milano SpA, Milan, Italy, Frisoni, Giovanni B. Univ Hosp Geneva, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, Pievani, Michela -- 0000-0002-1794-8987, Ferri, Raffaele -- 0000-0001-6937-3065, Guntekin, Bahar -- 0000-0002-0860-0524, triggiani, antonio ivano -- 0000-0003-3291-9452, Taylor, John-Paul -- 0000-0001-7958-6558, nobili, flavio -- 0000-0001-9811-0897, Emek-Savas, Derya Durusu -- 0000-0001-7042-697X, Stocchi, Fabrizio -- 0000-0002-5763-0033 |
| المصدر: | Clinical Neurophysiology Clinical Neurophysiology, Vol. 129, No 4 (2018) pp. 766-782 |
| بيانات النشر: | Elsevier Ireland Ltd, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, functional brain connectivity, mild cognitive impairment due to Alzheimer's disease (ADMCI), mild cognitive impairment due to Parkinson's disease (PDMCI), resting state EEG rhythms, sensory systems, neurology, physiology, Audiology, Neuropsychological Tests, 0302 clinical medicine, Mild Cognitive Impairment Due To, Beta Rhythm, Functional Brain Connectivity, Resting State EEG Rhythms, Cognitive impairment, Cerebral Cortex, Electroencephalography, Parkinson Disease, Sensory Systems, 3. Good health, Alpha Rhythm, Neurology, Functional brain connectivity, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), Resting state EEG rhythms, Sensory Systems, Neurology, Neurology (clinical), Physiology (medical), Female, Alzheimer's disease, Abnormality, medicine.medical_specialty, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Rest, Alpha (ethology), Alzheimer's Disease (ADMCI), Mild cognitive impairment due to Parkinson's disease (PDMCI), 03 medical and health sciences, Alpha rhythm, Alzheimer Disease, Physiology (medical), medicine, Humans, Cognitive Dysfunction, Resting state EEG rhythms, Aged, Retrospective Studies, Resting state fMRI, Receiver operating characteristic, business.industry, Functional brain connectivity, Parkinson's Disease (PDMCI), medicine.disease, Neurology (clinical), 030104 developmental biology, ddc:618.97, business, 030217 neurology & neurosurgery |
| الوصف: | WOS: 000427485900009 PubMed ID: 29448151 Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. H Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. Dr. Erol Basar passed away due to health problems on October 28th (November 18th 1938-October 28th 2017) in Istanbul, during the editorial processing of this manuscript. Until the end of his life, he had been working to the development of EEG science and its application in Clinical Neurophysiology. He leaves to all us an invaluable scientific legacy in the Science of Brain Rhythms and Human Cognition. He also leaves a permanent reminder of scientific passion, academic soul, and social responsibility to all fortunate people who met and knew him during his intense life. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-ITNetn.euTest). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1388-2457 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739c2f282cadb8ef7e5e37031b36225bTest https://hdl.handle.net/20.500.12511/2053Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....739c2f282cadb8ef7e5e37031b36225b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13882457 |
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