المؤلفون: Carmelo Pozzo, Floriana Camarda, Brunella Di Stefano, Giampaolo Tortora, Maria Alessandra Calegari, Maurizio Martini, F. Ardito, Annunziato Anghelone, Carmine Carbone, Felice Giuliante, Raffaella Vivolo, Maria Vellone, Maria Bensi, Lisa Salvatore, Michele Basso, M. Ribelli

مصطلحات موضوعية: Oncology, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Settore MED/18 - CHIRURGIA GENERALE, Cetuximab, Target therapy, Metastasis, Refractory, Encorafenib, Internal medicine, medicine, Humans, Liver surgery, neoplasms, Chemotherapy, Sulfonamides, business.industry, Gastroenterology, Precision oncology, medicine.disease, digestive system diseases, CRC, Regimen, BRAF mutation, Liver, Biomarker (medicine), Carbamates, business, Colorectal Neoplasms, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08580e193c4a97baa4e2f4dbfc5c4cbTest
http://hdl.handle.net/10807/193267Test

المؤلفون: Annabel Meireson, Piet Ost, Teofila Seremet, Jo Van Dorpe, Liesbeth Ferdinande, Nora Sundahl, Bart Neyns, Lieve Brochez, Vibeke Kruse

المساهمون: Clinical sciences, Medical Oncology, Laboratory for Medical and Molecular Oncology, Laboratory of Molecullar and Cellular Therapy

مصطلحات موضوعية: Oncology, Male, Cancer Research, Radiosurgery/adverse effects, Skin Neoplasms, Melanoma/blood, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Programmed Cell Death 1 Receptor/blood, Pembrolizumab, Kaplan-Meier Estimate, Chemoradiotherapy/adverse effects, 030218 nuclear medicine & medical imaging, GTP Phosphohydrolases, 0302 clinical medicine, Antineoplastic Agents, Immunological, Clinical endpoint, Melanoma, Skin Neoplasms/blood, Medicine(all), Radiation, GTP Phosphohydrolases/blood, Chemoradiotherapy, DNA, Neoplasm, Middle Aged, Progression-Free Survival, Nivolumab, Response Evaluation Criteria in Solid Tumors, 030220 oncology & carcinogenesis, Female, medicine.drug, Proto-Oncogene Proteins B-raf, Adult, Antineoplastic Agents, Immunological/adverse effects, medicine.medical_specialty, DNA, Neoplasm/blood, Ipilimumab, Radiosurgery, Drug Administration Schedule, 03 medical and health sciences, Internal medicine, medicine, Biomarkers, Tumor, Humans, Radiology, Nuclear Medicine and imaging, Progression-free survival, Aged, Proto-Oncogene Proteins B-raf/blood, business.industry, Membrane Proteins/blood, Membrane Proteins, medicine.disease, Nivolumab/adverse effects, Radiation therapy, Biomarkers, Tumor/blood, business, Progressive disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f6019cfc276207deb92a753bddb0b2Test
https://biblio.vub.ac.be/vubir/phase-2-trial-of-nivolumab-combined-with-stereotactic-body-radiation-therapy-in-patients-with-metastatic-or-locally-advanced-inoperable-melanomaTest(707a28c4-923a-46bd-96f3-69c0fb0f2a41).html

المؤلفون: Tosi, F, Magni, E, Amatu, A, Mauri, G, Bencardino, K, Truini, M, Veronese, S, De Carlis, L, Ferrari, G, Nichelatti, M, Sartore-Bianchi, A, Siena, S

المساهمون: Tosi, F, Magni, E, Amatu, A, Mauri, G, Bencardino, K, Truini, M, Veronese, S, De Carlis, L, Ferrari, G, Nichelatti, M, Sartore-Bianchi, A, Siena, S

مصطلحات موضوعية: BRAF, Colorectal cancer biomarker, Colorectal cancer prognosi, KRAS, Liver metastase, Colorectal Neoplasm, Disease-Free Survival, Hepatectomy, Human, Liver Neoplasm, Mutation, Prognosi, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), Oncology, Gastroenterology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28216246; info:eu-repo/semantics/altIdentifier/wos/WOS:000408269300004; volume:16; issue:3; firstpage:e153; lastpage:e163; numberofpages:11; journal:CLINICAL COLORECTAL CANCER; http://hdl.handle.net/10281/198028Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85012875416; http://www.journals.elsevier.com/clinical-colorectal-cancerTest

الإتاحة: https://doi.org/10.1016/j.clcc.2017.01.004Test
http://hdl.handle.net/10281/198028Test
http://www.journals.elsevier.com/clinical-colorectal-cancerTest

المؤلفون: Federica Tosi, Katia Bencardino, Luciano De Carlis, Gianluca Mauri, Silvio Veronese, Alessio Amatu, Elena Magni, Michele Nichelatti, Andrea Sartore-Bianchi, Giovanni Ferrari, Mauro Truini, Salvatore Siena

المساهمون: Tosi, F, Magni, E, Amatu, A, Mauri, G, Bencardino, K, Truini, M, Veronese, S, De Carlis, L, Ferrari, G, Nichelatti, M, Sartore-Bianchi, A, Siena, S

المصدر: Clinical Colorectal Cancer

مصطلحات موضوعية: 0301 basic medicine, Oncology, Liver metastase, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Multivariate analysis, Colorectal cancer, Prognosi, medicine.medical_treatment, Colorectal Neoplasm, medicine.disease_cause, Disease-Free Survival, BRAF, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Colorectal cancer prognosi, KRAS, Humans, Medicine, Hepatectomy, neoplasms, Colorectal cancer biomarker, Oncogene, business.industry, Liver Neoplasms, Hazard ratio, Gastroenterology, Prognosis, medicine.disease, digestive system diseases, Confidence interval, 3. Good health, 030104 developmental biology, Liver Neoplasm, 030220 oncology & carcinogenesis, Meta-analysis, Mutation, Colorectal Neoplasms, business, Human

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8728199634e862c5902ac932d1822ec5Test
http://hdl.handle.net/10281/198028Test

المؤلفون: Graziani, Grazia, Artuso, Simona, De Luca, Anastasia, Muzi, Alessia, ROTILI, Dante, Scimeca, Manuel, Atzori, Maria Grazia, Ceci, Claudia, MAI, Antonello, Leonetti, Carlo, Levati, Lauretta, Bonanno, Elena, Tentori, Lucio, Caccuri, Anna Maria

المساهمون: Graziani, Grazia, Artuso, Simona, De Luca, Anastasia, Muzi, Alessia, Rotili, Dante, Scimeca, Manuel, Atzori, Maria Grazia, Ceci, Claudia, Mai, Antonello, Leonetti, Carlo, Levati, Lauretta, Bonanno, Elena, Tentori, Lucio, Caccuri, Anna Maria

مصطلحات موضوعية: BRAF, glutathione transferase, JNK, melanoma, NBDHEX, vemurafenib, animal, antineoplastic agent, cell line, tumor, dose-response relationship, drug, drug resistance, neoplasm, enzyme activation, human, indole, map kinase signaling system, male, mice, nude, oxadiazole, protein kinase inhibitor, proto-oncogene proteins b-raf, solubility, sulfonamide, water, xenograft model antitumor assay, pharmacology, biochemistry

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25795251; info:eu-repo/semantics/altIdentifier/wos/WOS:000353858800002; volume:95; issue:1; firstpage:16; lastpage:27; numberofpages:12; journal:BIOCHEMICAL PHARMACOLOGY; http://hdl.handle.net/11573/884194Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84930886228; www.elsevier.com/locate/biochempharm

الإتاحة: https://doi.org/10.1016/j.bcp.2015.03.004Test
http://hdl.handle.net/11573/884194Test

المؤلفون: Kazuhiro Ohara, Edward R. Kastenhuber, Piro Lito, Michael Saborowski, Takaaki Miura, Christof Fellmann, Nobuya Ishii, Eric W. Joseph, Neal Rosen, Christine Lukacs, Jingyin Yue, Martha Solomon, Scott W. Lowe, Kenji Morikami, Anna Saborowski, Sunyana Gadal

المصدر: Cancer Cell. (5):697-710

مصطلحات موضوعية: Cancer Research, Indoles, endocrine system diseases, Mutant, MAP Kinase Kinase 1, medicine.disease_cause, Mice, Coumarins, Phosphorylation, RNA, Small Interfering, Vemurafenib, Extracellular Signal-Regulated MAP Kinases, Melanoma, Gene knockdown, Sulfonamides, Oncology, Benzamides, RNA Interference, raf Kinases, KRAS, medicine.drug, Proto-Oncogene Proteins B-raf, MAP Kinase Signaling System, Pyridones, Mice, Nude, Pyrimidinones, Biology, Article, Cell Line, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins, medicine, Animals, Humans, neoplasms, Protein Kinase Inhibitors, Oncogene, TNF Receptor-Associated Factor 3, Diphenylamine, Cell Biology, Surface Plasmon Resonance, medicine.disease, digestive system diseases, HEK293 Cells, Drug Resistance, Neoplasm, Cancer research, ras Proteins, V600E

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c70d2d8328ae21aca4e8bd16c7e2d53Test

المؤلفون: Tobi Nagel, Frank McCormick, John Tellew, John Chan, Huili Zhai, Darrin Stuart, Marco Wallroth, Stephen F. Hardy, Matthew Holderfield, Laura Tandeske, Mohammad Hekmat-Nejad, Hanne Merritt

المصدر: Cancer Cell. (5):594-602

مصطلحات موضوعية: MAPK/ERK pathway, Proto-Oncogene Proteins B-raf, Cancer Research, endocrine system diseases, MAP Kinase Signaling System, medicine.disease_cause, Adenosine Triphosphate, Cell Line, Tumor, medicine, Humans, Phosphorylation, Protein kinase A, neoplasms, chemistry.chemical_classification, Oncogene, Chemistry, Autophosphorylation, Cell Biology, digestive system diseases, Proto-Oncogene Proteins c-raf, Enzyme, Oncology, Cell culture, Cancer research, raf Kinases, Carcinogenesis, V600E

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ee5cb17c8d5a21e26f0f146bf169eeTest

المؤلفون: Manjula Santhanakrishnan, Nicholas Theodosakis, Glenn Merlino, David Dankort, Ildiko Erdelyi, David P. Curley, Laura Huang, Goran Micevic, Marcus Bosenberg, Viswanathan Muthusamy, Nabeel Bardeesy, Martin McMahon, William Damsky, Katrina Meeth, Michael A. Davies, M. Raza Zaidi, James T. Platt, Scott Tighe

المصدر: Cancer Cell. (1):41-56

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Cancer Research, Skin Neoplasms, Molecular Sequence Data, Melanoma, Experimental, Mechanistic Target of Rapamycin Complex 2, Biology, AMP-Activated Protein Kinases, Mechanistic Target of Rapamycin Complex 1, Protein Serine-Threonine Kinases, mTORC2, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, CDKN2A, Cell Line, Tumor, medicine, Nevus, Animals, Humans, skin and connective tissue diseases, Protein kinase B, neoplasms, PI3K/AKT/mTOR pathway, Cyclin-Dependent Kinase Inhibitor p16, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Melanoma, TOR Serine-Threonine Kinases, Cell Biology, Melanocytic nevus, medicine.disease, digestive system diseases, MicroRNAs, Oncology, 030220 oncology & carcinogenesis, Multiprotein Complexes, Mutation, Cancer research, Melanocytes, V600E, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044ff3927b36cd5f042454e90436d94Test

المؤلفون: Bonnie E. Gould Rothberg, Manjula Santhanakrishnan, Lara E. Rosenbaum, David Dankort, David L. Rimm, James T. Platt, Marcus Bosenberg, David P. Curley, Makoto Mark Taketo, William Damsky, Martin McMahon

المصدر: Cancer Cell. (6):741-754

مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Lung Neoplasms, Skin Neoplasms, Transcription, Genetic, Melanoma, Experimental, Kaplan-Meier Estimate, Piperazines, Metastasis, Mice, 0302 clinical medicine, Tumor Cells, Cultured, Phosphorylation, beta Catenin, 0303 health sciences, Protein Stability, Melanoma, Wnt signaling pathway, Cell Transformation, Neoplastic, Oncology, Gene Knockdown Techniques, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Benzamides, Imatinib Mesylate, Melanocytes, Colorectal Neoplasms, Signal Transduction, Proto-Oncogene Proteins B-raf, Mice, 129 Strain, Mice, Transgenic, Biology, Article, 03 medical and health sciences, medicine, Animals, Humans, PTEN, neoplasms, Protein kinase B, PI3K/AKT/mTOR pathway, 030304 developmental biology, Splenic Neoplasms, PTEN Phosphohydrolase, Cell Biology, medicine.disease, Antigens, Differentiation, Enzyme Activation, Mice, Inbred C57BL, Pyrimidines, Imatinib mesylate, Cancer research, biology.protein, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be8670ebdea02852cfac85a39f570a4Test

المؤلفون: Felix Dietlein, Martin R. Sprick, Bastian Kalb, Daniel Rauh, Jirina Bartkova, Elisa M. Noll, Lars Tharun, Allan Bradley, Alessandro Torgovnick, Cornelia Mauch, Reinhard Büttner, Helen Künstlinger, Andreas Trumpp, Winfried Randerath, Kato Kambartel, Roman K. Thomas, Roland Rad, Florian Siedek, André Richters, Anna Schmitt, Jürgen Wolf, Mladen Jokic, Alexander Strong, H. Christian Reinhardt, Thorsten Persigehl, Luka Ozretić, Dieter Saur, Jiri Bartek, Christian Jüngst

المصدر: Cell

مصطلحات موضوعية: Lung Neoplasms, Cell cycle checkpoint, endocrine system diseases, Mutant, Medizin, Apoptosis, Bioinformatics, medicine.disease_cause, Mice, 0302 clinical medicine, Tumor Cells, Cultured, Enzyme Inhibitors, Mitotic catastrophe, 0303 health sciences, Intracellular Signaling Peptides and Proteins, Drug Synergism, 3. Good health, synergism, Chk-1, MK2, Kras, cancer, 030220 oncology & carcinogenesis, Heterografts, Adenocarcinoma, KRAS, Proto-Oncogene Proteins B-raf, DNA damage, Adenocarcinoma of Lung, Antineoplastic Agents, Protein Serine-Threonine Kinases, Biology, General Biochemistry, Genetics and Molecular Biology, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Proto-Oncogene Proteins, medicine, Animals, Humans, CHEK1, neoplasms, 030304 developmental biology, Biochemistry, Genetics and Molecular Biology(all), Cell Cycle Checkpoints, medicine.disease, digestive system diseases, Disease Models, Animal, enzymes and coenzymes (carbohydrates), Checkpoint Kinase 1, Cancer cell, ras Proteins, Cancer research, Protein Kinases, Neoplasm Transplantation, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e292ad27ffc043d2860ae26b51664674Test