Punctuated Evolution of Prostate Cancer Genomes
| العنوان: | Punctuated Evolution of Prostate Cancer Genomes |
|---|---|
| المؤلفون: | Yotam Drier, Daniel Auclair, Andrey Sivachenko, Ashutosh K. Tewari, Gordon Saksena, Michelle Cipicchio, Gad Getz, Levi A. Garraway, Scott L. Carter, Philip W. Kantoff, Robert C. Onofrio, Gregory V. Kryukov, Theresa Y. MacDonald, Himisha Beltran, Jean-Philippe Theurillat, David Soong, Alessandro Romanel, Kristian Cibulskis, Kristin G. Ardlie, Eliezer M. Van Allen, Todd R. Golub, Francesca Demichelis, Matthew Meyerson, Candace Guiducci, Christopher E. Barbieri, Alex H. Ramos, Douglas Voet, Elizabeth Nickerson, Mark A. Rubin, Wendy Winckler, Sylvan C. Baca, Gunther Boysen, Mahmoud Ghandi, Davide Prandi, Olivier Elemento, Naoki Kitabayashi, Andrea Sboner, Eric S. Lander, Kyung Park, Michael S. Lawrence, Stacey Gabriel, Juan Miguel Mosquera, Michael F. Berger |
| المساهمون: | Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Lander, Eric S. |
| المصدر: | PMC Cell |
| بيانات النشر: | Elsevier Inc. |
| مصطلحات موضوعية: | Male, Biology, SPOP, Adenocarcinoma, medicine.disease_cause, Genome, Article, General Biochemistry, Genetics and Molecular Biology, Cohort Studies, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, medicine, Humans, 030304 developmental biology, Genetics, Chromosome Aberrations, 0303 health sciences, Chromothripsis, Biochemistry, Genetics and Molecular Biology(all), Genome, Human, Prostatic Neoplasms, Chromoplexy, medicine.disease, 3. Good health, Gene Expression Regulation, Neoplastic, Neuroendocrine Tumors, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Human genome, Carcinogenesis, Genome-Wide Association Study |
| الوصف: | The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes, but the spectrum of genome-wide alterations has not been profiled extensively in this disease. We sequenced the genomes of 57 prostate tumors and matched normal tissues to characterize somatic alterations and to study how they accumulate during oncogenesis and progression. By modeling the genesis of genomic rearrangements, we identified abundant DNA translocations and deletions that arise in a highly interdependent manner. This phenomenon, which we term “chromoplexy,” frequently accounts for the dysregulation of prostate cancer genes and appears to disrupt multiple cancer genes coordinately. Our modeling suggests that chromoplexy may induce considerable genomic derangement over relatively few events in prostate cancer and other neoplasms, supporting a model of punctuated cancer evolution. By characterizing the clonal hierarchy of genomic lesions in prostate tumors, we charted a path of oncogenic events along which chromoplexy may drive prostate carcinogenesis. National Human Genome Research Institute (U.S.). Large Scale Sequencing Program (U54 HG003067) |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0092-8674 |
| DOI: | 10.1016/j.cell.2013.03.021 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d350e20adb3ac4f10a0a74caa6de640fTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d350e20adb3ac4f10a0a74caa6de640f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00928674 |
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| DOI: | 10.1016/j.cell.2013.03.021 |