Intestinal Alkaline Phosphatase in Stool: A Novel Biomarker for Metabolic Diseases
| العنوان: | Intestinal Alkaline Phosphatase in Stool: A Novel Biomarker for Metabolic Diseases |
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| المؤلفون: | Jean-Paul Lallès |
| المساهمون: | Alimentation Adaptations Digestives, Nerveuse et Comportementales (ADNC), Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Nutrition Humaine |
| المصدر: | EBioMedicine 12 (2), 1866. (2015) EBioMedicine EBioMedicine, Elsevier, 2015, 2 (12), pp.1866. ⟨10.1016/j.ebiom.2015.12.001⟩ EBioMedicine, Vol 2, Iss 12, p 1866 (2015) |
| بيانات النشر: | Elsevier BV, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, L-Arg, L-homoarginine, viruses, BMI, body mass index, IAP-KO, IAP knockout, TNAP, tissue non-specific alkaline phosphatase, lcsh:Medicine, Gut flora, Systemic inflammation, commentaire, Feces, 0302 clinical medicine, Intestinal mucosa, Risk Factors, Intestinal Mucosa, IAP, intestinal alkaline phosphatase, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, 0303 health sciences, lcsh:R5-920, biology, Incipient diabetes, General Medicine, Middle Aged, insulino- résistance, 3. Good health, Intestines, AP, alkaline phosphatase, Hypertension, 030211 gastroenterology & hepatology, Female, medicine.symptom, biological phenomena, cell phenomena, and immunity, lcsh:Medicine (General), biomarqueur, Research Article, Autre (Sciences du Vivant), Adult, musculoskeletal diseases, medicine.medical_specialty, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Context (language use), General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Insulin resistance, Metabolic Diseases, Internal medicine, Diabetes mellitus, Fatty liver, medicine, phosphatase alcaline, Humans, FPG, fasting plasma glucose, Obesity, Glucose intolerance, Malo, 030304 developmental biology, Aged, lcsh:R, biology.organism_classification, medicine.disease, Alkaline Phosphatase, maladie métabolique, Enzyme Activation, body regions, Endocrinology, Diabetes Mellitus, Type 2, l-Phe, l-phenylalanine, Case-Control Studies, Commentary, LPS, lipopolysaccharides, The metabolic syndrome, Metabolic syndrome, Biomarkers |
| الوصف: | Mice deficient in intestinal alkaline phosphatase (IAP) develop type 2 diabetes mellitus (T2DM). We hypothesized that a high level of IAP might be protective against T2DM in humans. We determined IAP levels in the stools of 202 diabetic patients and 445 healthy non-diabetic control people. We found that compared to controls, T2DM patients have approx. 50% less IAP (mean +/− SEM: 67.4 +/− 3.2 vs 35.3 +/− 2.5 U/g stool, respectively; p Graphical abstract Highlights • Diabetes patients have very low levels of intestinal alkaline phosphatase (IAP) in their stool. • Obese people with high IAP do not develop diabetes. • A low level of IAP in a healthy person is indicative of having the incipient (latent) metabolic syndrome (diabetes). • Approximately 65% of the healthy population have the incipient metabolic syndrome including incipient diabetes. • ‘Temporal IAP profiling’ should diagnose the incipient metabolic syndrome (diabetes). Currently, diabetes is diagnosed by high blood sugar, for example having fasting plasma glucose (FPG) > 7.0 mmol/l. High FPG is associated only with already established diabetes, and therefore FPG cannot predict years in advance whether a person have incipient (latent) diabetes. This study shows that diabetes patients have very low levels of the gut enzyme intestinal alkaline phosphatase (IAP) in their stool indicating a protective role of IAP against diabetes. Even obese people do not develop diabetes if their IAP levels are high. Approx. 65% of healthy people have low IAP suggesting that these people have the incipient (latent) metabolic syndrome including incipient diabetes, and are very vulnerable to develop diabetes and other metabolic disorders in the near future. The study suggests that regular monitoring of stool IAP (temporal IAP profiling) might be very helpful to diagnose ‘incipient’ diabetes, the metabolic syndrome and other metabolic disorders. |
| وصف الملف: | application/pdf |
| تدمد: | 2352-3964 |
| DOI: | 10.1016/j.ebiom.2015.12.001 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2dcd596afe49f56779e7aeecfe418fTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb2dcd596afe49f56779e7aeecfe418f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2015.12.001 |