المؤلفون: Gestur Vidarsson, Lars Hviid, Mary Lopez-Perez, Mads Larsen

المصدر: Trends in Parasitology, 38(6), 428. Elsevier Limited

مصطلحات موضوعية: Plasmodium falciparum malaria, Erythrocytes, Fc region, Fcγ receptors, Plasmodium falciparum, Protozoan Proteins, Antibodies, Protozoan, Antigens, Protozoan, Adaptive Immunity, antibody effector function, acquired immunity, Infectious Diseases, Immunoglobulin G, parasitic diseases, fucosylation, Humans, Parasitology, Malaria, Falciparum

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https://doi.org/10.1016/j.pt.2022.02.008Test

المؤلفون: Qiuying Cheng, John M. Ong'echa, Angela O. Achieng, Bernard Guyah, Collins Ouma, Christophe G. Lambert, Douglas J Perkins

المصدر: EBioMedicine

مصطلحات موضوعية: Male, 0301 basic medicine, Research paper, medicine.medical_treatment, Interleukin-1beta, PBMCs, Peripheral blood mononuclear cells, LAIR2, Leukocyte-associated immunoglobulin like receptor-2, PfHz, Plasmodium falciparum haemozoin, LAIR1, Leukocyte-associated immunoglobulin like receptor-1, SHP-1, SH2 domain-containing tyrosine phosphatase-1, Pathogenesis, chemistry.chemical_compound, 0302 clinical medicine, PCN, Pigment containing neutrophils, TNF-α, Tumor necrosis factor alpha, Malaria, Falciparum, Receptors, Immunologic, 050207 economics, Receptor, Leukocyte-associated immunoglobulin like receptor-1, Leukocyte-associated immunoglobulin like receptor-2, P. falciparum, Plasmodium falciparum, 050208 finance, CLL, Chronic lymphocytic leukaemia, ITIM, immuno-tyrosine inhibition motifs, biology, Protein Tyrosine Phosphatase, Non-Receptor Type 6, 05 social sciences, Anemia, General Medicine, SMA, Severe malarial anaemia, 3. Good health, HFRS, haemorrhagic fever with renal syndrome, Child, Preschool, HIV-1, Human immunodeficiency virus 1, 030220 oncology & carcinogenesis, IL-6, Interleukin 6, Female, Tumor necrosis factor alpha, Antibody, Signal Transduction, C1q, Complement component 1q, Hemeproteins, SHP-2, SH2 domain-containing tyrosine phosphatase-2, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immune system, Phagocytosis, SLE, Systemic lupus erythematosus, Complement component 1q, In vivo, 0502 economics and business, medicine, Humans, SMA, severe malarial anaemia, Interleukin 6, Plasmodium falciparum malaria, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Complement C1q, LAIR1, Plasmodium falciparum haemozoin, Antagonist, Infant, PCM, Pigment containing monocytes, NF-κB, Immunotherapy, AML, Acute myeloid leukaemia, 030104 developmental biology, chemistry, NF-κB, Nuclear factor-kappa beta, Immunology, Leukocytes, Mononuclear, IL-1β, Interleukin 1 beta, biology.protein, PCR, Polymerase chain reaction, business, Biomedical sciences

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https://doi.org/10.1016/j.ebiom.2019.06.040Test

المؤلفون: Lore Cools, Sven Mangelinckx, Matthias D'hooghe, Tim Van de Walle

المصدر: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

مصطلحات موضوعية: CANCER-THERAPY, Quinoline, Antineoplastic Agents, Medicinal chemistry, Antimalarials, Neoplasms, Drug Discovery, Medicine and Health Sciences, TYROSINE KINASE INHIBITORS, Humans, Antimalarial Agent, BIOLOGICAL EVALUATION, Cancer, Pharmacology, BETA-HEMATIN FORMATION, Molecular Structure, Traditional medicine, ANTIPROLIFERATIVE ACTIVITY, Chemistry, Organic Chemistry, Plasmodium parasite, PLASMODIUM-FALCIPARUM MALARIA, IN-VITRO, General Medicine, Anticancer drug, TOPOISOMERASE-I, Malaria, COLCHICINE BINDING-SITE, Quinolines, GUANYLTHIOUREA DERIVATIVES

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https://doi.org/10.1016/j.ejmech.2021.113865Test

المؤلفون: Lucy C Okell, Hannah C Slater, Azra C. Ghani

المساهمون: Medical Research Council (MRC), Medicines for Malaria Venture, The Royal Society

المصدر: Trends in Parasitology

مصطلحات موضوعية: ANTIMALARIAL-DRUGS, 0301 basic medicine, Artemether/lumefantrine, Plasmodium vivax, Drug Resistance, Mycology & Parasitology, Drug resistance, 0302 clinical medicine, MULTIDRUG-RESISTANCE, Malaria, Falciparum, SUB-SAHARAN AFRICA, media_common, 11 Medical And Health Sciences, PHARMACOKINETIC-PHARMACODYNAMIC MODELS, Infectious Diseases, Drug development, POTENTIAL IMPACT, Life Sciences & Biomedicine, medicine.drug, Drug, Opinion, medicine.medical_specialty, media_common.quotation_subject, Plasmodium falciparum, 030231 tropical medicine, malaria, Biology, Antimalarials, 03 medical and health sciences, ARTEMETHER-LUMEFANTRINE, Pharmacokinetics, medicine, Humans, mathematical modelling, GAMETOCYTE CARRIAGE, Disease Eradication, Intensive care medicine, Special Issue: Drugs and Vaccines, Science & Technology, drug-based strategies, business.industry, PLASMODIUM-FALCIPARUM MALARIA, Models, Theoretical, 06 Biological Sciences, medicine.disease, biology.organism_classification, drug development, Biotechnology, OPERATIONAL STRATEGIES, 030104 developmental biology, Drug Design, Pharmacodynamics, Parasitology, 07 Agricultural And Veterinary Sciences, ARTEMISININ COMBINATION THERAPIES, business, Malaria

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المؤلفون: Tiziana Masini, Anna K. H. Hirsch, Blijke S. Kroezen

المصدر: Drug Discovery Today. 18:1256-1262

مصطلحات موضوعية: Drug, ISOPRENOID BIOSYNTHESIS, media_common.quotation_subject, Allosteric regulation, Druggability, Mevalonic Acid, Biology, BINDING-SITES, 4-CYCLODIPHOSPHATE SYNTHASE, 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE, Anti-Infective Agents, Drug Discovery, Humans, CRYSTAL-STRUCTURE, Molecular Targeted Therapy, Enzyme Inhibitors, Non-mevalonate pathway, Mode of action, media_common, Pharmacology, chemistry.chemical_classification, Drug discovery, PLASMODIUM-FALCIPARUM MALARIA, Drug Resistance, Microbial, 2C-METHYL-D-ERYTHRITOL-2, Biosynthetic Pathways, Enzymes, Isoprenoid biosynthesis, Enzyme, chemistry, Biochemistry, ESCHERICHIA-COLI, Drug Design, MYCOBACTERIUM-TUBERCULOSIS, Allosteric Site

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https://doi.org/10.1016/j.drudis.2013.07.003Test

المؤلفون: Cathleen Magowan, Philip S. Low, Heidi M. Van Dort, Jackson Yeung, Ross L. Coppel, Narla Mohandas, Karena L. Waller, Joy Liang, Wataru Nunomura

المصدر: Monash University

مصطلحات موضوعية: Ankyrins, Knob-associated histidine-rich protein, Plasmodium falciparum, Protozoan Proteins, KAHRP, Biology, Ankyrin, PfHRP1, ANK1, Anion Exchange Protein 1, Erythrocyte, parasitic diseases, Animals, Spectrin, Phosphorylation, Malaria, Falciparum, Band 3, Molecular Biology, chemistry.chemical_classification, Plasmodium falciparum malaria, Binding Sites, Erythrocyte Membrane, EPB41, biology.organism_classification, Phosphoproteins, Cell biology, Protein–protein interaction, Biochemistry, chemistry, Erythrocyte cytoskeleton, biology.protein, Molecular Medicine, Peptides, Binding domain

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