المؤلفون: Mae, Shin-Ichi, Hattanda, Fumihiko, Morita, Hiroyoshi, Nozaki, Aya, Katagiri, Naoko, Ogawa, Hanako, Teranaka, Kaori, Nishimura, Yu, Kudoh, Aoi, Yamanaka, Sanae, Matsuse, Kyoko, Ryosaka, Makoto, Watanabe, Akira, Soga, Tomoyoshi, Nishio, Saori, Osafune, Kenji

المساهمون: 前, 伸一, 八反田, 文彦, 盛田, 大義, 野崎, 彩, 片桐, 直子, 寺中, 香, 西村, 優, 工藤, 葵, 山中, 早苗, 松瀬, 恭子, 兩阪, 誠, 渡辺, 亮, 曽我, 朋義, 西尾, 妙織, 長船, 健二

مصطلحات موضوعية: human induced pluripotent stem cell, autosomal dominant polycystic kidney disease, ureteric bud, collecting duct, organoid, in vitro model, high-throughput screening

العلاقة: https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/231201-010000.htmlTest; https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/231201-010000.htmlTest; http://hdl.handle.net/2433/286477Test; Cell Reports; 42; 12; 113431

الإتاحة: http://hdl.handle.net/2433/286477Test

المؤلفون: Mae, Shin-Ichi, Ryosaka, Makoto, Sakamoto, Satoko, Matsuse, Kyoko, Nozaki, Aya, Igami, Maiko, Kabai, Ryotaro, Watanabe, Akira, Osafune, Kenji

المساهمون: 前, 伸一, 兩坂, 誠, 坂本, 智子, 野崎, 彩, 渡辺, 亮, 長船, 健二, 80502947

مصطلحات موضوعية: human induced pluripotent stem cell, ureteric bud, collecting duct, branching, expansion culture, tip cell, monitoring method, cryopreservation method, disease model

وصف الملف: application/pdf

العلاقة: https://www.kyoto-u.ac.jp/ja/research-news/2020-08-03Test; http://hdl.handle.net/2433/253549Test; Cell Reports; 32; 107963

الإتاحة: http://hdl.handle.net/2433/253549Test

المؤلفون: Takeshi Tada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Yasuyuki Hayashi, Hideaki Okuyama, Tsunetaro Morino, Yoshiyuki Kasai, Hiromi Kojima, Koichi Omori

المصدر: Regenerative Therapy
Regenerative Therapy, Vol 19, Iss, Pp 77-87 (2022)

مصطلحات موضوعية: Medicine (General), ET, Eustachian tube, CPM, carboxypeptidase M, Middle ear, PBS, phosphate-buffered saline, Biomedical Engineering, KRT5, cytokeratin5, NBRP, National BioResource Project, Ac-TUB, acetylated α-tubulin, Biomaterials, R5-920, X-SCID, x-linked severe combined immunodeficient, hiPSC, human induced pluripotent stem cell, OCT, optimal cutting temperature, PET, polyethylene terephthalate, Cholesteatoma, AEC, airway epithelial cell, Otitis media, Transplantation, QH573-671, EDTA, ethylenediaminetetraacetic acid, HNA, human nuclear antigen, Induced pluripotent stem cell, respiratory system, MUC5AC, mucin5AC, Original Article, PFA, paraformaldehyde, Cytology, DAPI, 4′,6-diamidino-2-phenylindole, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec36b4e75932341532501f7bd56465d0Test
https://doi.org/10.1016/j.reth.2022.01.001Test

المؤلفون: Shio Mitsuzawa, Risako Ono, Mitsuru Ishikawa, Hiroya Ono, Rumiko Izumi, Masashi Aoki, Kensuke Ikeda, Ryo Funayama, Takefumi Sone, Matsuyuki Shirota, Shohei Kaneda, Hiroaki Mitsuhashi, Jiro Kawada, Akiyuki Ohno, Teruo Fujii, Hideyuki Okano, Satoru Morimoto, Ayumi Nishiyama, Keiko Nakayama, Shion Osana, Naoko Nakamura, Tomomi Shijo, Tetsuya Akiyama, Hitoshi Warita, Yoshiho Ikeuchi, Naoki Suzuki, Tadashi Nakagawa

المصدر: Stem Cell Reports

مصطلحات موضوعية: 0301 basic medicine, amyotrophic lateral sclerosis (ALS), Neurite, Induced Pluripotent Stem Cells, In situ hybridization, Biology, Biochemistry, TARDBP, Article, 03 medical and health sciences, 0302 clinical medicine, human-induced pluripotent stem cell (hiPSC)-derived motor neurons, Genetics, medicine, Animals, Humans, Axon, Amyotrophic lateral sclerosis, Zebrafish, Homeodomain Proteins, Motor Neurons, Gene knockdown, Amyotrophic Lateral Sclerosis, Cell Biology, Motor neuron, biology.organism_classification, medicine.disease, Axons, neurite length, Cell biology, DNA-Binding Proteins, Phenotype, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, nervous system, Gene Knockdown Techniques, Mutation, Transcriptome, 030217 neurology & neurosurgery, TAR-DNA binding protein (TARDBP), Transcription Factors, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9de8b5691c3559895f6932175691db1Test
https://doi.org/10.1016/j.stemcr.2021.04.021Test

المؤلفون: Marie A. Chaix, James Ellis, Cedric Manlhiot, Emily Lam, Paul C. Nathan, Neha Parmar, Anne Christie, Jane Lougheed, Paul F. Kantor, Guoliang Meng, Luc Mertens, Anastasia Miron, Leonard S. Sender, Stacey Marjerrison, Shayna Zelcer, Ashok Kumar Manickaraj, David C. Hodgson, Rejane Dillenburg, Seema Mital, Oyediran Akinrinade, Herschel Rosenberg, Roderick Yao, Caroline Kinnear, Myriam Lafreniere-Roula, Mylene Bassal

المساهمون: Pediatrics

المصدر: Paediatrics Publications
JACC: CardioOncology

مصطلحات موضوعية: H2AX, H2A family member X, Oncology, Cardiac & Cardiovascular Systems, PREDICTION, VARIANT, Cardiomyopathy, DMSO, dimethyl sulfoxide, THERAPY, Pediatrics, LVEF - Left ventricular ejection fraction, AUC, area under the curve, risk prediction, GSEA, gene set enrichment analysis, IC50, half-maximal inhibitory concentration, TUMOR, LVEF, left ventricular ejection fraction, echocardiography, Genetic risk, Original Research, mRNA, messenger RNA, PGP, Personal Genome Project, RF, random forest, machine learning, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Clinical risk factor, Cancer survivorship, SKAT, sequence kernel association test, medicine.medical_specialty, DOXORUBICIN, Anthracycline, MAF, minor allele frequency, anthracycline, MECHANISMS, Internal medicine, genomics, medicine, GENOME-WIDE ASSOCIATION, LV, left ventricular, SNV, single-nucleotide variant, Cardiotoxicity, Science & Technology, CARDIOMYOPATHY, hiPSC-CM, human induced pluripotent stem cell–derived cardiomyocyte, business.industry, medicine.disease, DOX, doxorubicin, Pediatric cancer, CI, confidence interval, OR, odds ratio, cancer survivorship, Cardiovascular System & Cardiology, RISK-FACTORS, business, cardiomyopathy

وصف الملف: application/pdf; text/html

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9640c808872a8ac2a5f1d998b90f334Test
https://doi.org/10.1016/j.jaccao.2020.11.004Test

المؤلفون: David J. Mooney, Andrew S. Khalil, Rudolf Jaenisch

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: Drug Evaluation, Preclinical, Preclinical studies, Pharmaceutical Science, 02 engineering and technology, hESC, human embryonic stem cell, NTD, neural tube closure defect, GEM, genetically engineered mouse, NIH, United States National Institutes of Health, Neoplasms, hiPSC, human induced pluripotent stem cell, Drug Discovery, DMPK, drug metabolism and pharmacokinetics studies, 2D, two-dimensional, media_common, Stem cell engineering, PKPD, Pharmacokinetic-pharmacodynamic studies, Vaccines, 0303 health sciences, Neurodegenerative Diseases, HTS, high-throughput screen, 021001 nanoscience & nanotechnology, MPS, microphysiological system, ECM, extracellular matrix, Disease modeling, Risk analysis (engineering), Drug development, Microphysiological systems, Models, Animal, 0210 nano-technology, FDA, United States Food and Drug Administration, Drug, BBB, blood-brain barrier, media_common.quotation_subject, Bioengineering, ADME, absorption, distribution, metabolism, and excretion studies, In Vitro Techniques, Models, Biological, Article, PK, drug pharmacokinetics, 03 medical and health sciences, Lack of efficacy, Animals, Humans, Engineering tool, Tissue engineering, Obesity, 030304 developmental biology, 3D, three-dimensional, HCT, human clinical trials, Clinical trial, DARPA, United States Defense Advanced Research Projects Agency, hPSC, human pluripotent stem cell, PD, drug pharmacodynamics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27450d16dc16ed032dd279f5267ef128Test
https://doi.org/10.1016/j.addr.2020.09.012Test

المؤلفون: Jessie Pöche, Anna Dmitrieva, Konstanze Fisher, Tomasz Kolanowski, Sinah Hansen, Stefan Grünzner, Mario Schubert, Kaomei Guan, Ali El-Armouche, Mathias Busek, Björn Binnewerg, Frank Sonntag, Florian Schmieder, Andreas Richter

المساهمون: Publica

المصدر: Acta Biomaterialia. 102:273-286

مصطلحات موضوعية: oxygen control, Induced Pluripotent Stem Cells, Microfluidics, 0206 medical engineering, Biomedical Engineering, 02 engineering and technology, Biochemistry, Sarcomere, Biomaterials, Contractility, Tissue engineering, Biomimetics, Humans, Myocytes, Cardiac, human induced pluripotent stem cell-derived cardiomyocytes, Induced pluripotent stem cell, Molecular Biology, microfluidic system, maturation, Chemistry, hemodynamic force, Cell Differentiation, General Medicine, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Cell Hypoxia, In vitro, Cell biology, Drug development, 0210 nano-technology, Developmental biology, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c68d3495d94e5f62e8429cfd4c2f23Test
https://doi.org/10.1016/j.actbio.2019.11.044Test

المؤلفون: Zwartsen, Anne, de Korte, Tessa, Nacken, Peter, de Lange, Dylan W, Westerink, Remco H S, Hondebrink, Laura, dIRAS RA-1, One Health Toxicologie, Dep IRAS

المساهمون: dIRAS RA-1, One Health Toxicologie, Dep IRAS

المصدر: Journal of Molecular and Cellular Cardiology, 136, 102. Academic Press Inc.
Journal of Molecular and Cellular Cardiology, 136, 102-112. ELSEVIER SCI LTD

مصطلحات موضوعية: 0301 basic medicine, Drug, Indoles, Cell Survival, media_common.quotation_subject, Induced Pluripotent Stem Cells, hERG, Drug Evaluation, Preclinical, Dofetilide, QT prolongation, 030204 cardiovascular system & hematology, Pharmacology, 03 medical and health sciences, Alkaloids, 0302 clinical medicine, Cocaine, Nifedipine, Mexiletine, Toxicity Tests, Journal Article, Humans, Medicine, Myocytes, Cardiac, Amphetamine, Molecular Biology, Cells, Cultured, media_common, Psychotropic Drugs, Cardiotoxicity, Dose-Response Relationship, Drug, biology, Illicit Drugs, business.industry, Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), MDMA, Designer drugs, Long QT Syndrome, 030104 developmental biology, Microelectrode array (MEA), Functional cardiotoxicity screening, New psychoactive substances (NPS), biology.protein, Cardiology and Cardiovascular Medicine, business, Microelectrodes, Drug-induced cardiotoxicity, medicine.drug

وصف الملف: application/pdf; image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af868889d26c80fbde478afaaca52edTest
https://doi.org/10.1016/j.yjmcc.2019.09.007Test

المؤلفون: Geraldine M. Mitchell, Kiryu K. Yap, Jarmon G Lees, Diego Marre, Shiang Y. Lim, Wayne A. Morrison, Jason A. Palmer, Yi-Wen Gerrand, Anne M. Kong, Alice Pébay

المصدر: Acta Biomaterialia. 94:281-294

مصطلحات موضوعية: CD31, Angiogenesis, Induced Pluripotent Stem Cells, Polyurethanes, 0206 medical engineering, Biomedical Engineering, Neovascularization, Physiologic, Mice, SCID, 02 engineering and technology, Biochemistry, NovoSorb porous scaffold, Cell Line, Biomaterials, Mice, vascular pedicle capillary sprouting, Tissue engineering, In vivo, Animals, Humans, Inosculation, Induced pluripotent stem cell, Molecular Biology, Tissue Engineering, Tissue Scaffolds, Mesenchymal stem cell, human induced pluripotent stem cell, tissue flaps, Endothelial Cells, General Medicine, Plastic Surgery Procedures, 021001 nanoscience & nanotechnology, silicon tissue engineering chamber, 020601 biomedical engineering, Capillaries, derived endothelial cell capillary network, Endothelial stem cell, 0210 nano-technology, Porosity, Biotechnology, Biomedical engineering

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c8e75c6480bcc733a07d16f0cc512dTest
https://doi.org/10.1016/j.actbio.2019.05.067Test

المؤلفون: Tzu-Tang Wei, Mark Chandy, Masataka Nishiga, Angela Zhang, Kaavya Krishna Kumar, Dilip Thomas, Amit Manhas, Siyeon Rhee, Johanne Marie Justesen, Ian Y. Chen, Hung-Ta Wo, Saereh Khanamiri, Johnson Y. Yang, Frederick J. Seidl, Noah Z. Burns, Chun Liu, Nazish Sayed, Jiun-Jie Shie, Chih-Fan Yeh, Kai-Chien Yang, Edward Lau, Kara L. Lynch, Manuel Rivas, Brian K. Kobilka, Joseph C. Wu

المصدر: Cell, vol 185, iss 10

مصطلحات موضوعية: UK Biobank, Cardiovascular, Medical and Health Sciences, Billy Martin tetrad, General Biochemistry, Genetics and Molecular Biology, human-induced pluripotent stem cell, Substance Misuse, Mice, GPCR, Receptor, Cannabinoid, CB1, cardiovascular disease, Receptors, 2.1 Biological and endogenous factors, Animals, G protein-coupled receptor, Dronabinol, Aetiology, Receptors, Cannabinoid, Cannabinoid, Cannabis, Cannabinoid Receptor Agonists, Inflammation, Analgesics, Cannabinoid Research, Prevention, in vivo ligand binding, Neurosciences, in silico drug screening, Endothelial Cells, Biological Sciences, Atherosclerosis, CB1, Genistein, Heart Disease, Good Health and Well Being, Cardiovascular Diseases, Hallucinogens, Drug Abuse (NIDA only), marijuana, Receptor, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87b620ac3685eb34a92395276835686Test
https://doi.org/10.1016/jTest.cell.2022.04.005