المؤلفون: Xiaoying Guan, Jun Zhao, Wenjuan Zhang, Junlin Zhou, Jianhong Zhao, Junjie Mao, Tiejun Gan

المصدر: Alexandria Engineering Journal, Vol 60, Iss 1, Pp 1291-1297 (2021)

مصطلحات موضوعية: Pathology, medicine.medical_specialty, business.industry, 020209 energy, General Engineering, Image processing, 02 engineering and technology, Engineering (General). Civil engineering (General), 01 natural sciences, Mr imaging, 010305 fluids & plasmas, Magnetic resonance imaging, Pathological grade, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Medicine, Oligodendroglial Tumor, Oligodendrogliomas, TA1-2040, business, Pathological

الوصف: Medical image processing and its quantitative analysis plays a vital role in several clinical scenarios, such as diagnosis as well as treatment. The results of this study show that there are 478 mRNAs differentially expressed in low grade as compared to anaplastic oligodendroglial tumor (2 Fold greater, p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e26b1c3fb548b5295bada38cc72f19Test
https://doi.org/10.1016/j.aej.2020.10.051Test

المؤلفون: Wonhyoung Park, Jeong Hoon Kim, Jaesung Ahn, Heui Seung Lee, Young Hoon Kim, Jung Cheol Park

المصدر: World Neurosurgery. 129:e73-e80

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Subarachnoid hemorrhage, Population, Brain tumor, Magnetic resonance angiography, Meningioma, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, medicine, Humans, Oligodendroglial Tumor, education, Aged, Retrospective Studies, education.field_of_study, medicine.diagnostic_test, Brain Neoplasms, business.industry, Incidence, Astrocytoma, Intracranial Aneurysm, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Female, Surgery, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery, Follow-Up Studies

الوصف: Objective The association of primary brain tumors with coexisting unruptured intracranial aneurysms (UIAs) has been debated, and treatment strategies have not yet been established. We evaluated the flow association between brain tumors and coexisting UIAs and the outcomes of patients with brain tumor who did not receive treatment of coexisting UIAs. Methods The medical records of patients with coexisting UIAs and brain tumors who had undergone surgical tumor resection were retrospectively analyzed to evaluate the incidence of UIAs according to tumor type, association of arterial feeder vessels and coexisting UIAs, and the occurrence of subarachnoid hemorrhage during the follow-up period for patients who had not receive treatment for the UIAs. Results Of the 55 patients, 21 (38.9%) had undergone treatment of UIAs and 33 (61.1%) had received regular follow-up examinations without UIA treatment. Two patients (6.1%) developed subarachnoid hemorrhage. Of the 33 patients with astrocytic or oligodendroglial tumors who had not undergone treatment of UIAs, 2 had experienced an interval increase. Flow-related UIAs were found to be significantly more common in patients with astrocytic or oligodendroglial tumors than in those with tumors of other histological types (P = 0.01). Conclusions The incidence of UIAs among patients with primary brain tumors appears to be greater than that in the general population. An interval increase in aneurysm size and aneurysmal rupture was observed in 2 patients with astrocytic or oligodendroglial tumors. We would recommend perioperative treatment of flow-related UIAs in patients with astrocytic or oligodendroglial tumors and noninvasive evaluations such as magnetic resonance angiography if coexisting UIAs remain untreated.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59aeb1d4f2bc6d8d6d8fb25e15624336Test
https://doi.org/10.1016/j.wneu.2019.05.023Test

المؤلفون: Yunwei Ou, Baiyun Liu, Liang Wu, Weiming Liu

المصدر: World Neurosurgery. 128:448-451

مصطلحات موضوعية: Adult, medicine.medical_specialty, Skin Neoplasms, medicine.medical_treatment, Oligodendroglioma, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Enhancing Lesion, Humans, Medicine, Oligodendroglial Tumor, External beam radiotherapy, Craniotomy, Scalp, medicine.diagnostic_test, Brain Neoplasms, business.industry, Magnetic resonance imaging, medicine.disease, Radiation therapy, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Female, Radiotherapy, Adjuvant, Surgery, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery

الوصف: Background Scalp metastases from anaplastic oligodendroglioma (AO) are extremely rare and mostly involve intracranial recurrence or widely metastatic disease. Here we describe an exceptional case of histopathologically proven scalp metastasis of AO 6 years after surgical resection and postoperative adjuvant radiation. Case Description A 42-year-old woman presented with several months of progressive headache and dizziness. Preoperative magnetic resonance imaging (MRI) showed an irregular enhancing lesion in the left frontal lobe extending to the ependymal surface. Left frontal craniotomy was performed through a coronal approach, and gross total resection was achieved. Pathologic examination confirmed a World Health Organization grade III AO. The patient subsequently received 60 Gy of external beam radiotherapy in 30 fractions over 6 weeks. During 8 years of follow-up, the patient remained symptom free, and no evidence of intracranial recurrence was found. However, 6 years after intracranial tumor resection, the patient noticed a subcutaneous mass in her right frontal scalp, which was the site contralateral to her craniotomy. MRI revealed a homogeneously marked enhancing nodular lesion in the subcutaneous tissue of the right frontal scalp without intracranial recurrence. Gross total resection was performed, and the pathologic findings, which identified the mass as an AO, were consistent with those of the primary left frontal tumor. Conclusions This study presents a rare case of long-term AO scalp metastasis without intracranial recurrence. Intraoperative seeding and longer survival for oligodendroglial tumors may cause this rare entity. Optimal surgical strategies and standard operative procedures can promote the prevention of iatrogenic seeding.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52f013e26e0e8ddaad581d423156bb4Test
https://doi.org/10.1016/j.wneu.2019.05.109Test

المؤلفون: Dana Khaled Almedallah, Sari Saleh Al-Suhaibani, Hussain Khalid Al-Arfaj, Husam Saleh Al-Muhaish, Saeed A. Al-Jubran, Mohammad Saad Al-Aftan, Abdullah Abdulaziz Al-Hedaithy, Abdulrhman Hamad Al-Abdulwahhab, Abdulaziz Mohammad Al-Sharydah

المصدر: European Journal of Radiology Open, Vol 6, Iss, Pp 49-55 (2019)
European Journal of Radiology Open

مصطلحات موضوعية: lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, Pediatric brain tumor, lcsh:R895-920, Article, World health, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Magnetic resonance imaging, 0302 clinical medicine, Medicine, Effective diffusion coefficient, Radiology, Nuclear Medicine and imaging, Oligodendroglial Tumor, Grading (tumors), medicine.diagnostic_test, business.industry, body regions, Apparent diffusion coefficient, Pediatric brain, 030220 oncology & carcinogenesis, Differential diagnosis, Histopathology, Radiology, business

الوصف: Rationale and objectives: Classifying brain tumors is challenging, but recently developed imaging techniques offer the opportunity for neuroradiologists and neurosurgeons to diagnose, differentiate, and manage different types of brain tumors. Such advances will be reflected in improvements in patients’ life expectancy and quality of life. Among the newest techniques, the apparent diffusion coefficient (ADC), which tracks the rate of microscopic water diffusion within tissues, has become a focus of investigation. Recently, ADC has been used as a preoperative diffusion-weighted magnetic resonance imaging (MRI) parameter that facilitates tumor diagnosis and grading. Here, we aimed to determine the ADC cutoff values for pediatric brain tumors (PBTs) categorized according to the World Health Organization (WHO) classification of brain tumors. Materials and methods: We retrospectively reviewed 80 cases, and assessed them based on their MRI-derived ADC. These results were compared with those of WHO classification-based histopathology. Results: Whole-lesion ADC values ranged 0.225–1.240 × 10−3 mm2/s for ependymal tumors, 0.107–1.571 × 10−3 mm2/s for embryonal tumors, 0.1065–2.37801 × 10−3 mm2/s for diffuse astrocytic and oligodendroglial tumors, 0.5220–0.7840 × 10−3 mm2/s for other astrocytic tumors, and 0.1530–0.8160 × 10−3 mm2/s for meningiomas. These findings revealed the usefulness of ADC in the differential diagnosis of PBT, as it was able to discriminate between five types of PBTs. Conclusion: The application of an ADC diagnostic criterion would reduce the need for spectroscopic analysis. However, further research is needed to implement ADC in the differential diagnosis of PBT. Keywords: Apparent diffusion coefficient, Differential diagnosis, Magnetic resonance imaging, Pediatric brain tumor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b306c40dc4d596051e702de6a197ad2Test
https://doi.org/10.1016/j.ejro.2018.12.004Test

المؤلفون: Takaaki Beppu, Shunrou Fujiwara, Daigo Kojima, Yuichi Sato, Hiroaki Saura, Kuniaki Ogasawara

المصدر: Radiology Case Reports
Radiology Case Reports, Vol 13, Iss 1, Pp 220-224 (2018)

مصطلحات موضوعية: lcsh:Medical physics. Medical radiology. Nuclear medicine, musculoskeletal diseases, medicine.medical_specialty, lcsh:R895-920, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Vascularity, ASL, Medicine, Effective diffusion coefficient, Radiology, Nuclear Medicine and imaging, Oligodendroglial Tumor, Intracranial chondrosarcoma, business.industry, Conventional Chondrosarcoma, musculoskeletal system, medicine.disease, Neuroradiology, ADC, Frontal lobe, Arterial spin labeling, Radiology, Chondrosarcoma, medicine.symptom, business, Perfusion, 030217 neurology & neurosurgery, MRI

الوصف: Intracranial chondrosarcoma is a very rare malignant tumor of the central nervous system, and is difficult to preoperatively distinguish from other tumors using conventional imaging techniques. Here, we report the case of a 24-year-old woman who presented with mild headache due to chondrosarcoma in the frontal lobe. Preoperative conventional images showed findings typical of an oligodendroglial tumor. However, high apparent diffusion coefficient (ADC) value and extreme hypoperfusion on arterial spin labeling (ASL) were inconsistent with oligodendroglial tumor characteristics. The tumor was completely removed using a standard surgical procedure. Histologic diagnosis was a conventional (classic) chondrosarcoma. High ADC and hypoperfusion on ASL represented low cellularity and low vascularity within conventional chondrosarcoma, respectively. We discuss the utility of ADC and ASL for the preoperative diagnosis of conventional chondrosarcoma.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224b23c9ee5cb50f023a6cd266722f92Test
https://doi.org/10.1016/j.radcr.2017.09.021Test

المؤلفون: Arash Ghaffari-Rafi, George Samandouras

المصدر: World Neurosurgery. 133:366-380.e2

مصطلحات موضوعية: Oncology, medicine.medical_specialty, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Glioma, medicine, Humans, Oligodendroglial Tumor, Progression-free survival, Brain Neoplasms, business.industry, Astrocytoma, medicine.disease, Progression-Free Survival, Confidence interval, Survival Rate, Systematic review, Quartile, 030220 oncology & carcinogenesis, Surgery, Neurology (clinical), Oligodendroglioma, Neoplasm Grading, business, 030217 neurology & neurosurgery

الوصف: Background With the 2016 update of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System incorporating molecular subtyping to histology, WHO grade II diffuse astrocytic and oligodendroglial tumors are subcategorized by distinct molecular markers. There are no reported systematic reviews quantifying differences in progression-free survival (PFS) and overall survival (OS) on the basis of molecular subtypes of WHO grade II diffuse gliomas, against the background of administered treatments. Methods Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and the Cochrane Handbook of Systemic Reviews of Interventions, we conducted a systematic review through MEDLINE, Embase, and CENTRAL (Cochrane Central Register of Controlled Trails). Results For OS, the first quartile (25%), median (50%), third quartile (75%), and 95% confidence interval, respectively, were identified (in months): astrocytoma–wild-type WHO II (A-wt II): 22.8, 32.2, 40.7, and 21.6–61.2; astrocytoma-mutant WHO II (A-mt II): 69.85, 115.2, 128.4, and 55.4–164.0; oligodendroglioma WHO II (OD-II): 106.3, 163.7, 213.3, and 67.3–235.4 (P value = 0.0002). For PFS, the 25th, 50th, and 75th percentiles, and 95% confidence interval, respectively, are as follows (in months): A-wt II: 6.90, 17.45, 19.57, and 3.00–23.69; A-mt II: 37.20, 43.20, 55.63, and 35.7–60.0; OD-II: 47.42, 59.2, 88.28, and 46.3–91.2 (P value = 0.015). Conclusions This seems to be the first systematic review of OS and PFS in patients with WHO grade II low-grade gliomas (LGGs), against treatment modalities, in molecularly stratified subsets introduced by the WHO 2016 classification of central nervous system tumors. Overall, A-wt II was confirmed to have a significantly shorter OS than did A-mt II; no significant difference was found between OS of OD-II with A-wt II and A-mt II. In addition, all 3 molecular subtypes were found to have statistically significant differences between PFS, with OD-II having a statistically better PFS than A-mt II. These data can provide valuable prognostic insight to patients and clinicians. In addition, assessing survival differences enhances understanding of treatment recommendations against molecular markers and may facilitate future clinical trial design.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c599a98851dc26f85983a2fd2a3676Test
https://doi.org/10.1016/j.wneu.2019.08.111Test

المؤلفون: Yuanhao Chang, Yongzhi Wang, Rui-Chao Chai, Kenan Zhang, Fan Wu, Yu-Qing Liu, Tao Jiang, Kuanyu Wang, Zheng Zhao, Yu-Zhou Chang

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Proportional hazards model, business.industry, 1p/19q Codeletion, Malignancy, medicine.disease, Genome, Internal medicine, Glioma, medicine, WHO Grade III Glioma, Oligodendroglial Tumor, business, Gene

الوصف: Background: Co-deletion of chromosome arms 1p and 19q in oligodendroglial tumors is associated with chemosensitivity and favorable prognosis. Here, we explored the prognostic value of the expression of a panel of 1p19q genes in 1p/19q non-codeletion gliomas. Methods: We analyzed expression of 1p19q genes in 668 1p/19q non-codel gliomas obtained from The Cancer Genome Atlas (TCGA) (n = 447) and the Chinese Glioma Genome Atlas (CGGA) (n = 221) for training and validation, respectively. Least Absolute Shrinkage and Selection Operator Cox regression analysis was applied to build a gene risk signature. Results: Expression of 1p19q genes was significantly associated with the overall survival of patients with 1p/19q non-codel gliomas. We derived a risk signature of 25 selected 1p19q genes that successfully stratified the overall survival of 1p/19q non-codel glioma patients in both the TCGA and CGGA datasets into high- and low-risk groups (both P < 0.0001). Bioinformatics analysis revealed that the signature genes were significantly enriched in cell division, extracellular matrix, angiogenesis, DNA damage repair, and immune or inflammatory response processes, and these were supported by the immunohistochemistry. The risk signature not only predicted the chemoradiotherapeutic outcomes of glioblastoma and WHO grade III glioma patients but was also an independent prognostic marker for patients with 2016 WHO integrated diagnosis glioma subtypes. Conclusion: A risk signature consisting of 25 1p19q genes identified high-risk and low-risk categories of 1p/19q non-codel gliomas. This signature may be helpful for developing potential treatments strategies for these patients. Funding Statement: This work was supported by the National Natural Science Foundation of China (81773208, 81402052); the Beijing Nova Program (Z16110004916082); the National Key Research and Development Plan (2016YFC0902500). Declaration of Interests: The authors declare: "none." Ethics Approval Statement: This study was approved by the institutional review board of Beijing Tiantan Hospital.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1322a93a7e067584623e4c43215aba30Test
https://doi.org/10.2139/ssrn.3269595Test

المؤلفون: Georges Noël, C. Dehais, Laetitia Padovani, A. d’Hombres, F. Fauchon, F G Riet, Hassen Douzane, Loïc Feuvret, C. Jenny, C.-H. Canova, Y. Meng, Frédéric Dhermain, Maud Aumont, J. Jacob

المصدر: Radiotherapy and Oncology. 133:S386

مصطلحات موضوعية: Oncology, Radiation therapy, medicine.medical_specialty, business.industry, Internal medicine, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, Oligodendroglial Tumor, Hematology, business, Quality assurance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::73e8ad17226e3646dd58b34f82c2264dTest
https://doi.org/10.1016/s0167-8140Test(19)31173-9

المؤلفون: Derek Lee, Wai-Man Lui, Gilberto K.K. Leung, Jenny Kan-suen Pu, Stella Sun, Anderson Chun On Tsang, Xiao-Qin Zhang, Stanley Thian Sze Wong, Venus On Ying Man

المصدر: Neurobiology of Disease, Vol 48, Iss 1, Pp 1-8 (2012)

مصطلحات موضوعية: Adult, Oligodendroglioma, Brain tumor, Astrocytoma, Biology, Bioinformatics, Malignancy, lcsh:RC321-571, Glioma, medicine, Humans, Oligodendroglial Tumor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Brain Neoplasms, Gene Expression Profiling, LncRNA profiling, medicine.disease, Phenotype, Long non-coding RNA, Neurology, Cancer research, RNA, Long Noncoding

الوصف: Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e757889b02b3f89e2e53668cb299f5f0Test
https://doi.org/10.1016/j.nbd.2012.06.004Test

المؤلفون: Yukio Takeshima, Kaoru Kurisu, Taiichi Saito, Fumiyuki Yamasaki, Takako Kakuda, Yoshikazu Okada, Yuji Akiyama, Yoshinori Kajiwara, Kazuhiko Sugiyama, Nobukazu Abe

المصدر: European Journal of Radiology. 81:1863-1869

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Oligodendroglioma, Perfusion scanning, Astrocytoma, Sensitivity and Specificity, Diagnosis, Differential, White matter, Young Adult, Glioma, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Oligodendroglial Tumor, Child, Aged, Aged, 80 and over, medicine.diagnostic_test, Brain Neoplasms, business.industry, Reproducibility of Results, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, medicine.anatomical_structure, Female, Differential diagnosis, business, Magnetic Resonance Angiography

الوصف: The differentiation of oligodendroglial tumors from astrocytic tumors is important clinically, because oligodendroglial tumors are more chemosensitive than astrocytic tumors. This study was designed to clarify the usefulness of 3T MR perfusion imaging (PWI) in the histopathological differentiation between astrocytic and oligodendroglial tumors. This is because there is a growing interest in the diagnostic performance of 3T MR imaging, which has the advantages of a higher signal-to-noise ratio (SNR) and greater spatial and temporal resolution.This study retrospectively included 24 consecutive patients with supratentorial, WHO grade II and III astrocytic and oligodendroglial tumors (7 astrocytic, 10 oligoastrocytic, and 7 oligodendroglial tumors) that were newly diagnosed and resected between November 2006 and December 2009 at Hiroshima University Hospital. These patients underwent dynamic susceptibility contrast-enhanced (DSC) PWI relative cerebral blood volume (rCBV) measurements before treatment. Astrocytic tumors were designated as the astrocytic group, and oligoastrocytic and oligodendroglial tumors as the oligodendroglial group. The regions of interest with the maximum rCBV values within the tumors were normalized relative to the contra-lateral white matter (rCBVmax).The average rCBVmax of astrocytic tumors (2.01±0.68) was significantly lower than that of the oligoastrocytic (4.60±1.05) and oligodendroglial tumors (6.17±0.867) (P0.0001). A cut-off value of 3.0 allowed to differentiate the oligodendroglial group from the astrocytic group at 100% sensitivity and 87.5% specificity.The rCBVmax values obtained from 3T MR PWI may be useful as an adjunct to the postoperative histopathological diagnosis of glioma patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb8cd5ff77b602e760904120be1a442Test
https://doi.org/10.1016/j.ejrad.2011.04.009Test