المؤلفون: Sagae, Yusuke, Horie, Akihito, Yanai, Akihiro, Ohara, Tsutomu, Nakakita, Baku, Kitawaki, Yoshimi, Okunomiya, Asuka, Tani, Hirohiko, Yamaguchi, Ken, Hamanishi, Junzo, Lydon, John P., Daikoku, Takiko, Watanabe, Hideto, Mandai, Masaki

المساهمون: 寒河江, 悠介, 堀江, 昭史, 矢内, 晶太, 小原, 勉, 中北, 麦, 北脇, 佳美, 奥宮, 明日香, 山口, 建, 濵西, 潤三, 万代, 昌紀

مصطلحات موضوعية: Versican, Extracellular matrix, Uterine NK cell, Spiral artery, Fetal growth restriction, Preeclampsia

الوصف: The extracellular matrix (ECM) in the endometrium plays a crucial role in mammalian pregnancy. We have shown that versican secreted from the endometrial epithelium promotes embryo implantation. Versican is a proteoglycan, a major player in the provisional matrix, and versikine, its N-terminal fragment cleaved by ADAMTS proteinases, serves as a bioactive molecule. Here, since versican expression in the placenta was dynamically altered in humans and mice, we investigated the role of versican in pregnancy using uterine-specific Vcan deletion mice (uKO mice) and ADAMTS-resistant versican expressing mice (V1R mice). uKO mice exhibited insufficient spiral artery dilation, followed by fetal growth restriction and maternal hypertension. Further analysis revealed impaired proliferation of tissue-resident natural killer cells required for spiral artery dilation. V1R mice showed the same results as the control, eliminating the involvement of versikine. Our results provide a new concept that versican, one factor of ECM, contributes to placentation and following fetal growth.

العلاقة: http://hdl.handle.net/2433/286466Test; Matrix Biology; 115; 16; 31

الإتاحة: http://hdl.handle.net/2433/286466Test

المؤلفون: Suzuki, Takuma, Iizuka, Takashi, Kagami, Kyosuke, Matsumoto, Takeo, Yamazaki, Rena, Daikoku, Takiko, Horie, Akihito, Ono, Masanori, Hattori, Akira, Fujiwara, Hiroshi

المساهمون: Kanazawa University

المصدر: iScience ; volume 26, issue 9, page 107692 ; ISSN 2589-0042

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1016/j.isci.2023.107692Test
https://api.elsevier.com/content/article/PII:S2589004223017698?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2589004223017698?httpAccept=text/plainTest

المؤلفون: Wang, Yuming, Hongu, Tsunaki, Nishimura, Tatsunori, Takeuchi, Yasuto, Takano, Hiroshi, Daikoku, Takiko, Yao, Ryoji, Gotoh, Noriko

المصدر: Biochemical and Biophysical Research Communications ; volume 674, page 183-189 ; ISSN 0006-291X

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry, Biophysics

الإتاحة: https://doi.org/10.1016/j.bbrc.2023.06.074Test
https://api.elsevier.com/content/article/PII:S0006291X2300829X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0006291X2300829X?httpAccept=text/plainTest

المؤلفون: Nomura, Satoshi, Hosono, Takashi, Ono, Masanori, Daikoku, Takiko, Michihiro, Mieda, Kagami, Kyosuke, Iizuka, Takashi, Chen, Yuchen, Shi, Yifan, Morishige, Jun-ichi, Fujiwara, Tomoko, Fujiwara, Hiroshi, Ando, Hitoshi

المساهمون: Japan Society for the Promotion of Science

المصدر: The Journal of Nutrition ; volume 153, issue 8, page 2283-2290 ; ISSN 0022-3166

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1016/j.tjnut.2023.06.018Test
https://api.elsevier.com/content/article/PII:S0022316623724243?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022316623724243?httpAccept=text/plainTest

المؤلفون: Sagae, Yusuke, Horie, Akihito, Yanai, Akihiro, Ohara, Tsutomu, Nakakita, Baku, Kitawaki, Yoshimi, Okunomiya, Asuka, Tani, Hirohiko, Yamaguchi, Ken, Hamanishi, Junzo, Lydon, John P., Daikoku, Takiko, Watanabe, Hideto, Mandai, Masaki

المساهمون: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Japan Society for the Promotion of Science, National Institutes of Health, Takeda Science Foundation

المصدر: Matrix Biology ; volume 115, page 16-31 ; ISSN 0945-053X

مصطلحات موضوعية: Molecular Biology

الإتاحة: https://doi.org/10.1016/j.matbio.2022.11.004Test
https://api.elsevier.com/content/article/PII:S0945053X22001366?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0945053X22001366?httpAccept=text/plainTest

المؤلفون: Imamura, Rikako, Sugimoto, Masahiro, Horike, Shin-ichi, Terakawa, Jumpei, Fujita, Kazuki, Tamai, Ikumi, Daikoku, Takiko, Kato, Yukio, Arakawa, Hiroshi

المساهمون: Japan Society for the Promotion of Science

المصدر: Journal of Pharmaceutical Sciences ; ISSN 0022-3549

مصطلحات موضوعية: Pharmaceutical Science

الإتاحة: https://doi.org/10.1016/j.xphs.2024.04.014Test
https://api.elsevier.com/content/article/PII:S0022354924001424?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022354924001424?httpAccept=text/plainTest

المؤلفون: Hasan, Nazmul, Nagata, Naoto, Morishige, Jun-ichi, Islam, Md Tarikul, Jing, Zheng, Harada, Ken-ichi, Mieda, Michihiro, Ono, Masanori, Fujiwara, Hiroshi, Daikoku, Takiko, Fujiwara, Tomoko, Maida, Yoshiko, Ota, Tsuguhito, Shimba, Shigeki, Kaneko, Shuichi, Fujimura, Akio, Ando, Hitoshi

المساهمون: Japan Agency for Medical Research and Development, Kanazawa University - Kakuma Campus, Japan Society for the Promotion of Science

المصدر: Molecular Metabolism ; volume 49, page 101202 ; ISSN 2212-8778

مصطلحات موضوعية: Cell Biology, Molecular Biology

الإتاحة: https://doi.org/10.1016/j.molmet.2021.101202Test
https://api.elsevier.com/content/article/PII:S2212877821000429?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2212877821000429?httpAccept=text/plainTest

المؤلفون: Hosono, Takashi, Ono, Masanori, Daikoku, Takiko, Mieda, Michihiro, Nomura, Satoshi, Kagami, Kyosuke, Iizuka, Takashi, Nakata, Rieko, Fujiwara, Tomoko, Fujiwara, Hiroshi, Ando, Hitoshi

المساهمون: AF Office of Scientific Research, Japan Agency for Medical Research and Development

المصدر: Current Developments in Nutrition ; volume 5, issue 5, page nzab064 ; ISSN 2475-2991

مصطلحات موضوعية: Nutrition and Dietetics, Food Science, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1093/cdn/nzab064Test
https://api.elsevier.com/content/article/PII:S2475299122105391?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2475299122105391?httpAccept=text/plainTest
http://academic.oup.com/cdn/article-pdf/5/5/nzab064/37853558/nzab064.pdfTest

المؤلفون: Lee, Jin, Chen, Xiaoxi, Wang, Yuming, Nishimura, Tatsunori, Li, Mengjiao, Ishikawa, Satoko, Daikoku, Takiko, Kawai, Junya, Tojo, Arinobu, Gotoh, Noriko

المساهمون: Government of Japan Ministry of Education Culture Sports Science and Technology, Japan Agency for Medical Research and Development Department of Industrial Academic Collaboration, Japan Society for the Promotion of Science

المصدر: Biochemical and Biophysical Research Communications ; volume 584, page 7-14 ; ISSN 0006-291X

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry, Biophysics

الإتاحة: https://doi.org/10.1016/j.bbrc.2021.11.001Test
https://api.elsevier.com/content/article/PII:S0006291X2101500X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0006291X2101500X?httpAccept=text/plainTest

المؤلفون: Kanda, Tatsuhito, Kagami, Kyousuke, Iizuka, Takashi, Kasama, Haruki, Matsumoto, Takeo, Sakai, Yuya, Suzuki, Takuma, Yamamoto, Megumi, Matsuoka, Ayumi, Yamazaki, Rena, Hattori, Akira, Horie, Akihito, Daikoku, Takiko, Ono, Masanori, Fujiwara, Hiroshi

المصدر: Placenta ; volume 141, page 109 ; ISSN 0143-4004

مصطلحات موضوعية: Developmental Biology, Obstetrics and Gynecology, Reproductive Medicine

الإتاحة: https://doi.org/10.1016/j.placenta.2023.08.060Test
https://api.elsevier.com/content/article/PII:S0143400423005155?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0143400423005155?httpAccept=text/plainTest