المؤلفون: Giovanni Assenza, Lorenzo Ricci, Carlo Vico, Flavia Narducci, Marilisa Boscarino, Biagio Sancetta, Jacopo Lanzone, Pierantonio Menna, Mariana Fernandes, Clementina Lupo, Tommaso Tufo, Claudio Liguori, Biagio Nicola Mercuri, Vincenzo di Lazzaro, Mario Tombini

المصدر: Clinical Neurophysiology. 150:e101

مصطلحات موضوعية: Neurology, Physiology (medical), Neurology (clinical), Sensory Systems

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::683cb93b09fa66e97dc92e85375422c2Test
https://doi.org/10.1016/j.clinph.2023.03.097Test

المؤلفون: Mariangela Pierantozzi, Alessandro Stefani, Valentino De Franco, Matteo Spanetta, Nicola Biagio Mercuri, Alessandra Di Pucchio, Claudio Liguori, Rocco Cerroni

المصدر: Sleep Medicine. 81:307-311

مصطلحات موضوعية: Sleep Wake Disorders, medicine.medical_specialty, Levodopa, Parkinson's disease, Disease, Settore MED/26, Affect (psychology), 03 medical and health sciences, 0302 clinical medicine, Quality of life, Rating scale, Surveys and Questionnaires, Internal medicine, Humans, Medicine, Stage (cooking), business.industry, Parkinson Disease, General Medicine, medicine.disease, Sleep in non-human animals, 030228 respiratory system, Disease Progression, Quality of Life, business, 030217 neurology & neurosurgery, medicine.drug

الوصف: Non-motor symptoms (NMS) frequently impact health-related quality of life (HRQoL) in patients with Parkinson's Disease (PD). Sleep problems represent one of the main NMS complained by PD patients. In this observation study, sleep problems measured by Parkinson's Disease Sleep Scale - 2nd version (PDSS-2), and HRQoL measured by Parkinson's Disease Questionnaire-39 (PDQ39) were quantified in patients with PD ranging from mild to moderate-advanced disease stages, and correlated to motor impairment and anti-PD therapy.We included idiopathic PD patients who underwent PDSS-2 and PDQ39. Moreover, we assessed patients' motor symptoms by rating the Unified Parkinson's Disease Rating Scale (UPDRS) - III section (motor examination), patients' PD status following HY stage, and levodopa equivalent daily dose (LEDD).One-hundred and fifty-four patients with PD were included and distributed for HY stage. PDSS-2 and PDQ39 total and sub-items scores significantly increased with the HY stage. PDSS-2 total score significantly correlated with PDQ39 total score (γ = 0.63, P 0.01). Finally, distributing PD patients according to the PDSS-2 cut-off for detecting sleep disturbances, we found in poor sleepers (n = 58) higher PDQ39 scores than good sleepers (n = 89).Sleep problems are very common in patients with PD and severely impact on HRQoL. Sleep impairment and low HRQoL occur from the early stages of the disease and deteriorate along disease progression. Further studies investigating sleep and quality of life should be planned for targeting sleep improvement to increase HRQoL and possibly reduce motor impairment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a00569028474970a3d6e062d24c39eTest
https://doi.org/10.1016/j.sleep.2021.02.036Test

المؤلفون: Claudio Liguori, Samantha Mombelli, Mariana Fernandes, Marco Zucconi, Giuseppe Plazzi, Luigi Ferini-Strambi, Giancarlo Logroscino, Nicola Biagio Mercuri, Marco Filardi

المصدر: Sleep Medicine Reviews. 68:101762

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Neurology, Physiology (medical), Neurology (clinical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3adf67a9b5bf85ee72bc0b0320863688Test
https://doi.org/10.1016/j.smrv.2023.101762Test

المؤلفون: Mariana Fernandes, Nicola Biagio Mercuri, Matteo Spanetta, Fabio Placidi, Claudio Liguori, Francesca Izzi

المصدر: Sleep Medicine. 100:S181

مصطلحات موضوعية: Adult, Male, Sleep Wake Disorders, medicine.medical_specialty, Sleep wake, Wake, Audiology, Settore MED/26, Epilepsy, Sleep-wake cycle, Medicine, Humans, Aged, Intra-daily variability, business.industry, General Medicine, Middle Aged, medicine.disease, Sleep in non-human animals, Actigraphy, Inter-daily stability, Circadian Rhythm, Neurology, Non-parametric circadian rhythm activity, Female, Neurology (clinical), business, Sleep

الوصف: This study aimed to assess the sleep-wake pattern in patients with epilepsy compared to controls.Patients with epilepsy and controls underwent a 14-day actigraphic recording to evaluate the rest-activity cycle. A sleep medicine interview was performed to exclude conditions interfering with the sleep-wake cycle in both patients and controls. Patients presenting seizures during the actigraphic recording were excluded. Daytime activity, nocturnal sleep, and non-parametric circadian rhythm activity (NPCRA) were analysed.Twenty-two patients (mean age 49.5 ± 19.84 years; 50% female) and 17 controls were included. Patients showed lower sleep efficiency and longer sleep latency than controls. NPCRA analysis showed lower inter-daily stability and higher intra-daily variability in patients, who also presented lower daytime activity and a longer central phase measure (CPM) than controls.Patients showed a significant alteration of the sleep-wake pattern, featured by lower synchronization and higher fragmentation of the rest-activity rhythm. Moreover, patients showed a delayed CPM compared with controls, corresponding to an evening chronotype tendency. Nocturnal sleep alteration and lower daytime activity were also evident. Therefore, patients with epilepsy present an alteration of the sleep-wake pattern and clinicians should increase their awareness about circadian rhythmicity dysregulation in epilepsy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6401faace790bb7044fedc80d66435aeTest
https://doi.org/10.1016/j.sleep.2022.05.488Test

المؤلفون: Francesca Izzi, Fabio Placidi, Claudio Liguori, Alberto Cordella, Sergio Bernardini, Marzia Nuccetelli, Nicola Biagio Mercuri

المصدر: Sleep Medicine. 56:171-176

مصطلحات موضوعية: Male, medicine.medical_specialty, Alzheimer's disease, Obstructive sleep apnea, Orexin, Sleep, β-Amyloid, Disease, Polysomnography, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Risk Factors, Internal medicine, mental disorders, medicine, Humans, Pathological, Aged, Orexins, Sleep Apnea, Obstructive, Amyloid beta-Peptides, medicine.diagnostic_test, Lumbar puncture, business.industry, Intermittent hypoxia, General Medicine, Middle Aged, medicine.disease, Sleep in non-human animals, Peptide Fragments, nervous system diseases, respiratory tract diseases, Endocrinology, 030228 respiratory system, Female, Settore MED/26 - Neurologia, business, Biomarkers, 030217 neurology & neurosurgery

الوصف: Background Obstructive Sleep Apnea (OSA) is associated with pathological changes of cerebral β-amyloid dynamics. Orexin has been demonstrated interfering with β-amyloid metabolism in Alzheimer's Disease (AD) pathology. The present study investigated cerebrospinal-fluid (CSF) β-amyloid40 (Aβ40), β-amyloid42 (Aβ42) and orexin levels in OSA patients compared to AD patients and controls. Methods OSA and AD patients were included in this study and compared to a group of controls. Patients and controls underwent lumbar puncture for the assessment of CSF Aβ40, Aβ42, tau proteins, orexin levels, and polysomnography to measure nocturnal sleep architecture. Results 20 OSA patients, 20 AD patients, and 15 controls were included in our study. OSA patients showed higher CSF orexin levels than AD patients and controls, and AD patients showed higher CSF orexin levels than controls. Moreover, CSF Aβ40 and Aβ42 were lower in OSA patients than controls, but higher in OSA patients compared to AD patients. However, AD patients showed lower CSF Aβ42 levels but comparable CSF Aβ40 levels than controls. Sleep macrostructure was similarly altered in OSA and AD patients compared to controls. Finally, the apnea-hypopnea index (AHI) was related to the ratio Aβ42/Aβ40 and CSF orexin levels in OSA patients. Conclusion This study proved the alteration of CSF orexin levels and β-amyloid isoforms 40 and 42 in OSA patients. We suppose that sleep disruption and intermittent hypoxia, the two core features of OSA, may induce orexinergic system and cerebral β-amyloid metabolism dysregulation. This evidence further supports the current hypothesis that OSA may possibly start AD neuropathological processes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630ab94366548c7445673ca6316072f1Test
https://doi.org/10.1016/j.sleep.2019.01.003Test

المؤلفون: Chiara Bedetti, Claudio Liguori, Cinzia Costa, Andrea Romigi, Paolo Eusebi, Elena Nardi Cesarini, Lucia Farotti, Paolo Calabresi, Michele Romoli, Lucilla Parnetti, Sabrina Siliquini, Nicola Biagio Mercuri

المصدر: Neurobiology of Aging. 73:61-67

مصطلحات موضوعية: Male, 0301 basic medicine, Aging, medicine.medical_specialty, Time Factors, Amyloid, Disease, Late Onset Disorders, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Alzheimer Disease, Internal medicine, 80 and over, medicine, Humans, Dementia, Cognitive Dysfunction, Prospective Studies, Cognitive decline, Prospective cohort study, CSF biomarkers, Pathological, Aged, Aged, 80 and over, Neuroscience (all), Amyloid beta-Peptides, business.industry, General Neuroscience, Neuropsychology, Beta amyloid, Alzheimer's disease, Middle Aged, medicine.disease, Peptide Fragments, Settore MED/26 - NEUROLOGIA, 030104 developmental biology, Disease Progression, Neurology (clinical), Developmental Biology, Geriatrics and Gerontology, Female, business, Biomarkers, 030217 neurology & neurosurgery, Follow-Up Studies

الوصف: Although amyloid pathology plays a role in epilepsy, little is known about the relationship between beta amyloid and progression to Alzheimer's disease (AD) among patients with late-onset epilepsy of unknown origin (LOEU). This multicenter, observational, prospective study enrolled 40 consecutive nondemented adults diagnosed with LOEU, together with 43 age- and sex-matched healthy controls. All patients completed neuropsychological tests, core CSF AD biomarkers assessment (Aβ1-42, total tau, and phosphorylated tau), and follow-up for a mean of 3 years to verify cognitive decline. Despite age and baseline cognitive performance were similar to healthy controls, patients with LOEU had significant prevalence of CSF pathological Aβ1-42 (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2ca354050b1c59c5fe4a05799c3addTest
https://doi.org/10.1016/j.neurobiolaging.2018.09.006Test

المؤلفون: Mariana Fernandes, Stefano Consoli, Francesca Izzi, F Dainese, Nicola Biagio Mercuri, Caterina Gaspari, Rosaria Renna, Fedele Dono, Mauro Pagliuca, Fabio Placidi, Claudio Liguori

المصدر: Epilepsy & Behavior. 125:108391

مصطلحات موضوعية: Adult, Male, Pediatrics, medicine.medical_specialty, Future studies, Migraine attacks, Pyridones, Migraine Disorders, Comorbidity, Settore MED/26, Behavioral Neuroscience, Epilepsy, Perampanel, chemistry.chemical_compound, Nitriles, medicine, Humans, Effective treatment, In patient, Antiseizure medication, business.industry, Follow-up, Middle Aged, Epileptic seizures, medicine.disease, Neurology, Migraine, chemistry, Rescue migraine medications, Anticonvulsants, Female, Observational study, Neurology (clinical), business

الوصف: Introduction Migraine is a common comorbidity in patients with epilepsy. Considering the proven associations and the common pathophysiological features linking epilepsy and migraine, some anti-seizure medications (ASMs) have been considered as a treatment for both disorders. This study aimed at assessing both the effectiveness of perampanel (PER) on epileptic seizures and migraine attacks in patients with epilepsy and comorbid migraine, as well as the reduction in the monthly mean rate usage of rescue migraine medications. Methods This observational, multi-centre study included adult patients with epilepsy and comorbid migraine who started PER to better control epileptic seizures and who were followed up for 12 months. Results Thirty-one patients were included (mean age 40.13 ± 13.13 years; 67.0% female). At the 12-month follow-up visit, 27 patients were continuing PER concomitantly with 1 (45.2%) or 2 ASMs (54.8%). A significant reduction in epileptic seizures, migraine attacks, and the monthly use of rescue migraine medications between baseline and both 6- and 12-month follow-up visits was documented. Conclusion PER demonstrated good effectiveness in reducing both epileptic seizures and migraine attacks in patients with comorbid epilepsy and migraine. Future studies with possibly larger samples are needed to evaluate the efficacy of PER in migraine other than epilepsy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aebd29f5c8ebed73a6f2876fc3dadbaTest
https://doi.org/10.1016/j.yebeh.2021.108391Test

المؤلفون: Antonio Pisani, Francesca Izzi, Girolama Alessandra Marfia, Fabio Placidi, Claudio Liguori, Benedetta Lauretti, Camilla Rocchi, Nicola Biagio Mercuri

المصدر: Sleep Medicine. 42:68-72

مصطلحات موضوعية: Male, Supine position, Tilt test, Valsalva Maneuver, medicine.medical_treatment, Diaphragmatic breathing, Blood Pressure, Autonomic nervous system, CPAP, Cardiovascular reflexes, Obstructive sleep apnea, SCOPA-Aut, 030204 cardiovascular system & hematology, Autonomic Nervous System, Cardiovascular System, 03 medical and health sciences, 0302 clinical medicine, medicine, Valsalva maneuver, Humans, Continuous positive airway pressure, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, business.industry, General Medicine, Middle Aged, medicine.disease, nervous system diseases, respiratory tract diseases, Blood pressure, Anesthesia, Reflex bradycardia, Settore MED/26 - Neurologia, business, 030217 neurology & neurosurgery

الوصف: Objective This study is aimed at evaluating whether Continuous Positive Airway Pressure treatment (CPAP) may affect autonomic nervous system (ANS) in male patients with severe obstructive sleep apnea (OSAS). Methods We compared autonomic symptoms of de novo severe OSAS patients, OSAS patients on chronic CPAP treatment and healthy controls, using the Scales for Outcome in Parkinson disease-Autonomic (SCOPA-AUT) questionnaire. All groups underwent cardiovascular function tests including head-up tilt test (HUTT), Valsalva maneuver, deep breathing, hand grip and cold face tests. Statistical significance was set at p Results Twelve de novo severe OSAS patients, 17 male OSAS on CPAP and 14 controls were studied. The mean SCOPA-AUT total score was significantly higher in de novo OSAS patients compared with controls. Regarding the distinct domains, both de novo OSAS and CPAP group had abnormalities in respect of controls in urinary sphere. In supine rest condition the baseline values of systolic blood pressure were significantly increased in untreated OSAS patients compared with controls, whereas the basal values of diastolic blood pressure were significantly higher in CPAP patients with respect to controls. After ten min of HUTT, diastolic blood pressure changes were significantly higher in controls compared to both OSAS groups. Untreated OSAS patients showed significant different responses at deep breathing compared to controls. Both OSAS groups had a significant reduction of reflex bradycardia at cold face test. Conclusions Our study shows that both treated and untreated OSAS patients complain of subjective autonomic symptoms like other sleep disorders reinforcing the close relationship between sleep and autonomic activity. Furthermore, cardiovascular reflexes indicate a tendency to hypertension and a reduced sensitivity to stimuli during wakefulness even in OSA patients on CPAP treatment, suggesting potentially permanent autonomic function deficits.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6910eb2cc8489f6def0ad11b5f601400Test
https://doi.org/10.1016/j.sleep.2017.09.029Test

المؤلفون: Michele Romoli, Cinzia Costa, Claudio Liguori, Carmen Calvello, Nicola Biagio Mercuri, Elena Nardi Cesarini, Lucilla Parnetti, Andrea Romigi, Paolo Calabresi, Paolo Eusebi, Lucia Farotti

المصدر: Journal of the Neurological Sciences. 429:117709

مصطلحات موضوعية: Late onset epilepsy, Pediatrics, medicine.medical_specialty, Neurology, business.industry, Etiology, medicine, Neurology (clinical), Cognitive decline, Longitudinal cohort, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4ed6e14caa5301816517bd744b18a081Test
https://doi.org/10.1016/j.jns.2021.117709Test

المؤلفون: Fabio Placidi, Claudio Liguori, Francesca Izzi, Chiara Giuseppina Bonomi, Alessandro Castelli, Andrea Pagano, Natalia Manfredi, Luisa Mari, Nicola Biagio Mercuri

المصدر: Journal of the Neurological Sciences. 429:119000

مصطلحات موضوعية: Rapidly progressive dementia, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Electroencephalography, Neurology, Creutzfeldt Jacob Disease, Internal medicine, Brain mri, medicine, Cardiology, Neurology (clinical), business, Value (mathematics)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::59eef6cc5d52adbed44231d2242e0ae5Test
https://doi.org/10.1016/j.jns.2021.119000Test