المؤلفون: Leino, Teppo O., Turku, Ainoleena, Urvas, Lauri, Adhikari, Karuna, Oksanen, Jouni, Steynen, Yana, Yli-Kauhaluoma, Jari, Xhaard, Henri, Kukkonen, Jyrki P., Wallén, Erik A. A.

مصطلحات موضوعية: agonist, azulene, medicinal chemistry, orexin receptor, sulfonamides, atsuleeni, lääkekemia

وصف الملف: application/pdf; fulltext

العلاقة: Bioorganic and Medicinal Chemistry; 88-89; 330800; Research Council of Finland; Suomen Akatemia; Leino, T. O., Turku, A., Urvas, L., Adhikari, K., Oksanen, J., Steynen, Y., Yli-Kauhaluoma, J., Xhaard, H., Kukkonen, J. P., & Wallén, E. A.A. (2023). Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists. Bioorganic and Medicinal Chemistry , 88-89 , Article 117325. https://doi.org/10.1016/j.bmc.2023.117325Test; CONVID_183153867; URN:NBN:fi:jyu-202305253251; http://urn.fi/URN:NBN:fi:jyu-202305253251Test

الإتاحة: http://urn.fi/URN:NBN:fi:jyu-202305253251Test

المؤلفون: Rüdiger Kornberger, Benjamin Berger, Jasper Dingemanse

المصدر: European Neuropsychopharmacology. 51:90-104

مصطلحات موضوعية: Pyrrolidines, Visual analogue scale, Citalopram, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Pharmacokinetics, mental disorders, Humans, Medicine, Single-Blind Method, Pharmacology (medical), Biological Psychiatry, business.industry, Imidazoles, Antagonist, Healthy Volunteers, Orexin receptor, 030227 psychiatry, Psychiatry and Mental health, Neurology, Tolerability, Pharmacodynamics, Orexin Receptor Antagonists, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug, Blood sampling

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9f9245670717330f545cd9619d54e6Test
https://doi.org/10.1016/j.euroneuro.2021.05.005Test

المؤلفون: Chun Wang, Zhao-Jun Wang, Fang Zhou, Xu-Dong Yan, Jin-Shun Qi, Yexin He, Hong-Yan Cai, Mei-Na Wu, Jun Zhang, Yi-Ying Li

المصدر: Neurobiology of Aging. 91:66-75

مصطلحات موضوعية: 0301 basic medicine, Aging, Long-Term Potentiation, Gene Expression, Hippocampus, Mice, Transgenic, Chronobiology Disorders, CREB, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, mental disorders, Animals, Neuroprostanes, Medicine, Cognitive Dysfunction, Circadian rhythm, Cognitive decline, Cyclic AMP Response Element-Binding Protein, Orexins, Amyloid beta-Peptides, Neuronal Plasticity, biology, business.industry, General Neuroscience, Suvorexant, Long-term potentiation, Azepines, Triazoles, Orexin receptor, Orexin, Disease Models, Animal, 030104 developmental biology, biology.protein, Orexin Receptor Antagonists, Neurology (clinical), Geriatrics and Gerontology, business, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6e7040f3362439af62b96660694b31Test
https://doi.org/10.1016/j.neurobiolaging.2020.02.020Test

المؤلفون: Tomoki Kimura, Hiroto Suzuki, Hirochi Tanji, Yoshinori Iba, Hiroki Murai

المصدر: Journal of Pharmacological Sciences, Vol 142, Iss 2, Pp 79-82 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, Chlorpromazine, Butorphanol, Midazolam, Pharmacology, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Anesthesia, Melatonin receptor agonist, Anesthetics, Mice, Inbred ICR, Isoflurane, Chemistry, Brotizolam, lcsh:RM1-950, Suvorexant, Imidazoles, Atipamezole, Azepines, Medetomidine, Triazoles, Orexin receptor, Drug Combinations, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, Indenes, Sleep Aids, Pharmaceutical, Molecular Medicine, Orexin Receptor Antagonists, 030217 neurology & neurosurgery, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bffc657759fba22fd241386728f6695Test
https://doi.org/10.1016/j.jphs.2019.12.003Test

المؤلفون: H. Dong, Chao Yang, Yinglu Guo, Dan Wang, Hua Li, M. Ran, Jin-Lian Li, Qianzi Yang, Xudong Zhang

المصدر: British Journal of Anaesthesia. 123:497-505

مصطلحات موضوعية: Male, medicine.medical_specialty, Optogenetics, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Dopamine, Internal medicine, mental disorders, medicine, Animals, Orexins, Isoflurane, business.industry, Dopaminergic Neurons, Ventral Tegmental Area, Dopaminergic, Orexin receptor, Rats, Orexin, Ventral tegmental area, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Endocrinology, nervous system, Anesthesia Recovery Period, Anesthetics, Inhalation, Models, Animal, Wakefulness, business, psychological phenomena and processes, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dfdc1d1a88f7c994942ebab59fc0d6Test
https://doi.org/10.1016/j.bja.2019.07.005Test

المؤلفون: Parham Reisi, Hojjatallah Alaei, Reza Fartootzadeh, Fatemeh Azizi

المصدر: Brain Research. 1719:176-182

مصطلحات موضوعية: Male, 0301 basic medicine, AM251, Nicotine, Cannabinoid receptor, Pyridines, medicine.medical_treatment, Pharmacology, Nucleus Accumbens, 03 medical and health sciences, 0302 clinical medicine, Piperidines, Orexin Receptors, mental disorders, medicine, Animals, Premovement neuronal activity, Rats, Wistar, Receptors, Cannabinoid, Molecular Biology, Neurons, Cannabinoids, Chemistry, musculoskeletal, neural, and ocular physiology, General Neuroscience, Ventral Tegmental Area, Isoquinolines, Orexin receptor, Rats, Orexin, Ventral tegmental area, 030104 developmental biology, medicine.anatomical_structure, nervous system, Conditioning, Operant, Pyrazoles, Orexin Receptor Antagonists, Neurology (clinical), Cannabinoid, psychological phenomena and processes, 030217 neurology & neurosurgery, Developmental Biology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d00377478850b74cb5a89e90220fccaTest
https://doi.org/10.1016/j.brainres.2019.05.042Test

المؤلفون: Yujie Ren, Cuihua Zhang, Qunlin Li

المصدر: Journal of the Taiwan Institute of Chemical Engineers. 100:1-17

مصطلحات موضوعية: Quantitative structure–activity relationship, Molecular model, Hydrogen bond, Chemistry, Stereochemistry, General Chemical Engineering, Druggability, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Orexin receptor, 0104 chemical sciences, Orexin, Molecule, Pharmacophore, 0210 nano-technology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d3e060587795df1559036dc921dae878Test
https://doi.org/10.1016/j.jtice.2019.03.018Test

المؤلفون: Ming-Zi Ran, Haizhi Hao, Cen Yang, Hailong Dong, Li-Na Zhang, Jiannan Li

المصدر: Neuropeptides. 75:25-33

مصطلحات موضوعية: Dorsal Raphe Nucleus, Male, 030209 endocrinology & metabolism, Serotonergic, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, Orexin-A, 0302 clinical medicine, Endocrinology, Dorsal raphe nucleus, mental disorders, Animals, Medicine, Microinjection, Neurons, Orexins, Isoflurane, Endocrine and Autonomic Systems, business.industry, digestive, oral, and skin physiology, General Medicine, Orexin receptor, Rats, Orexin, nervous system, Neurology, Anesthesia, Anesthetics, Inhalation, Serotonin, Arousal, business, psychological phenomena and processes, 030217 neurology & neurosurgery, Serotonergic Neurons, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855fe431eae966a5866f6d8d94f013cdTest
https://doi.org/10.1016/j.npep.2019.03.004Test

المؤلفون: Airi Otsuka, Yumiko Miyatake, Hiroshi Sakaue, Sachiko Chikahisa, Tetsuya Shiuchi, Hiroyoshi Sei

المصدر: Biochemical and Biophysical Research Communications. 514:166-172

مصطلحات موضوعية: Leptin, Male, 0301 basic medicine, medicine.medical_treatment, Biochemistry, 0302 clinical medicine, Orexin Receptors, Urea, Phosphorylation, STAT3, Neurons, Benzoxazoles, biology, Chemistry, digestive, oral, and skin physiology, Orexin receptor, Hypothalamus, 030220 oncology & carcinogenesis, Receptors, Leptin, Orexin Receptor Antagonists, Leptin transport, psychological phenomena and processes, hormones, hormone substitutes, and hormone antagonists, STAT3 Transcription Factor, medicine.medical_specialty, Intraperitoneal injection, Biophysics, Neuropeptide, 03 medical and health sciences, Physical Conditioning, Animal, Internal medicine, mental disorders, medicine, Animals, Naphthyridines, Exercise, Molecular Biology, Orexins, Leptin sensitivity, Cell Biology, Orexin, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, nervous system, Exercise Test, biology.protein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5a188356d8cebf47fcad086c9ed90aTest
https://doi.org/10.1016/j.bbrc.2019.04.145Test

المؤلفون: Charles M. Morin, Ellen Snyder, Duane B. Snavely, W. Joseph Herring, David Michelson, Kathryn M. Connor, Christopher Lines

المصدر: Sleep Medicine. 56:219-223

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Randomization, Adolescent, Placebo, Severity of Illness Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Sleep Initiation and Maintenance Disorders, Internal medicine, Outcome Assessment, Health Care, medicine, Insomnia, Humans, Aged, business.industry, Suvorexant, Azepines, General Medicine, Middle Aged, Triazoles, Orexin receptor, Insomnia severity index, Orexin, 030104 developmental biology, Female, Orexin Receptor Antagonists, medicine.symptom, Sleep onset, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd5c2dac73f42463c4454b5e9d3a969Test
https://doi.org/10.1016/j.sleep.2018.09.010Test