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1
المؤلفون: Hasina Banu, Hui Li, Rong Liu, Qin Pan, Liang Ma
المصدر: Biomedicine & Pharmacotherapy. 99:169-175
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Uterine Cervical Neoplasms, Antineoplastic Agents, Mice, SCID, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, medicine, Animals, Humans, Doxorubicin, Protein Methyltransferases, Enzyme Inhibitors, Pharmacology, Cervical cancer, Chemotherapy, business.industry, Cysmethynil, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Paclitaxel, chemistry, Apoptosis, 030220 oncology & carcinogenesis, ras Proteins, Cancer research, Protein prenylation, Female, business, Signal Transduction, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d347f809c8533237b905c9fa8de6ed0Test
https://doi.org/10.1016/j.biopha.2018.01.048Test -
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المؤلفون: Marcia A. Munoz, Jukka Mönkkönen, Michael J. Rogers
المصدر: Bone. 139:115493
مصطلحات موضوعية: 0301 basic medicine, Histology, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Protein Prenylation, Osteoclasts, 030209 endocrinology & metabolism, Bone and Bones, Bone resorption, 03 medical and health sciences, 0302 clinical medicine, Prenylation, Osteoclast, medicine, Humans, Small GTPase, Bone Resorption, Diphosphonates, Chemistry, Bisphosphonate, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Protein prenylation, Function (biology), Intracellular
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3e8897d2e7c35c694b5d9a073566bfTest
https://doi.org/10.1016/j.bone.2020.115493Test -
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المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: Benzimidazole, Geranylgeranyl Transferase, medicine.medical_treatment, Clinical Biochemistry, Organophosphonates, Protein Prenylation, Pharmaceutical Science, 01 natural sciences, Biochemistry, Article, chemistry.chemical_compound, Farnesyl diphosphate synthase, Drug Discovery, medicine, Humans, Molecular Biology, biology, 010405 organic chemistry, Organic Chemistry, Bisphosphonate, Phosphonate, 0104 chemical sciences, Isoprenoid biosynthesis, 010404 medicinal & biomolecular chemistry, chemistry, Enzyme specificity, biology.protein, Molecular Medicine, Protein prenylation, Benzimidazoles
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb954da6fd0277f55dfd58ab85e47a58Test
https://doi.org/10.1016/j.bmcl.2019.126757Test -
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المؤلفون: Marc L. Goalstone, Vasudeva Kamath, Anjaneyulu Kowluru
المصدر: Biochemical and Biophysical Research Communications. 391:895-898
مصطلحات موضوعية: medicine.medical_treatment, Protein Prenylation, Biophysics, Carbohydrate metabolism, Biology, Biochemistry, Article, Cell Line, Enzyme activator, Geranylgeranylation, Insulin-Secreting Cells, medicine, Animals, Secretion, Molecular Biology, Monomeric GTP-Binding Proteins, geography, Alkyl and Aryl Transferases, geography.geographical_feature_category, Insulin, Cell Biology, Islet, Rats, Enzyme Activation, Vesicular transport protein, Glucose, Protein prenylation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3b99e3f5cd20d2c5bf7326c1a1e6b9Test
https://doi.org/10.1016/j.bbrc.2009.11.159Test -
5The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts
المؤلفون: Zhiqiang Xu, Angela C. Hirbe, Anthony J. Apicelli, Anke J. Roelofs, Katherine N. Weilbaecher, Julie L. Prior, Michael J. Rogers, Mark C. Eagleton, David Piwnica-Worms, Stephanie N. Becker, Desiree H. Floyd, Hongju Deng, Lisa G. Lanigan
المصدر: Bone. 44:908-916
مصطلحات موضوعية: medicine.medical_specialty, Histology, Cell Survival, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Protein Prenylation, Osteoclasts, Bone Neoplasms, Mice, Transgenic, Zoledronic Acid, Article, Mice, Biphosphonate, Osteoclast, Cell Line, Tumor, Internal medicine, medicine, Animals, Neoplasm Metastasis, Tartrate-resistant acid phosphatase, Diphosphonates, biology, business.industry, Imidazoles, Bone metastasis, Geranyltranstransferase, Bisphosphonate, medicine.disease, Enzyme Activation, Mice, Inbred C57BL, Zoledronic acid, medicine.anatomical_structure, Endocrinology, RANKL, biology.protein, Cancer research, Protein prenylation, business, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c388b75915b8886e9039a6b4e61963ecTest
https://doi.org/10.1016/j.bone.2009.01.010Test -
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المؤلفون: Sarah R. Breevoort, David Z. Mokry, Timothy M. Dore, Walter K. Schmidt, Stephen B. Porter, Emily R. Hildebrandt
المصدر: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1773(6):853-862
مصطلحات موضوعية: Proteases, Saccharomyces cerevisiae Proteins, Methyltransferase, medicine.medical_treatment, Protein Prenylation, Antineoplastic Agents, Saccharomyces cerevisiae, Biology, CaaX protein, (acyloxy)methyl ketone, Article, Catalysis, Substrate Specificity, Prenylation, Drug Resistance, Fungal, Endopeptidases, medicine, Protease Inhibitors, Isoprenylation, Protein Methyltransferases, Molecular Biology, chemistry.chemical_classification, Metalloproteinase, Protease, Membrane Proteins, Metalloendopeptidases, Cell Biology, Ketones, Enzyme, Membrane protein, chemistry, Biochemistry, Protein prenylation, Post-translational modification, Proprotein Convertases, Drug Screening Assays, Antitumor, Peptides, Ras
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351eef78eee0e60ee1d5826dfd28c9ecTest
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المؤلفون: Michael J. Rogers, Marion Blank, J Pesonen, Markku Taskinen, Jukka Mönkkönen, Roger J. Phipps, S. Suri
المصدر: Bone. 29:336-343
مصطلحات موضوعية: Programmed cell death, medicine.medical_specialty, Histology, Cell Survival, Gastrointestinal Diseases, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Protein Prenylation, Mevalonic Acid, Apoptosis, In Vitro Techniques, Biology, Pharmacology, chemistry.chemical_compound, Geranylgeraniol, Prenylation, Internal medicine, In Situ Nick-End Labeling, medicine, Humans, Nitrogen Compounds, Diphosphonates, Cholesterol, rap1 GTP-Binding Proteins, Epithelial Cells, Bisphosphonate, Endocrinology, chemistry, Protein prenylation, Mevalonate pathway, Caco-2 Cells, Diterpenes, Cell Division
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152501439025cfbf38be5f5c94bf2069Test
https://doi.org/10.1016/s8756-3282Test(01)00589-0 -
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المؤلفون: R.G.G. Russell, Michael J. Rogers
المصدر: Bone. 25:97-106
مصطلحات موضوعية: Male, medicine.medical_specialty, Histology, Bone disease, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Osteoporosis, Protein Prenylation, Mevalonic Acid, Osteoclasts, Pharmacology, Bone resorption, Intestinal absorption, Bone remodeling, Structure-Activity Relationship, Biphosphonate, Internal medicine, medicine, Humans, Diphosphonates, Chemistry, Bisphosphonate, medicine.disease, Endocrinology, Protein prenylation, Female, Laboratories
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a9df35d402c50a2d3b0309bc5bb2e5Test
https://doi.org/10.1016/s8756-3282Test(99)00116-7 -
9
المصدر: Bioorganic & Medicinal Chemistry. 18:7212-7220
مصطلحات موضوعية: Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Farnesyl diphosphate synthase, Prenylation, Cell Line, Tumor, Drug Discovery, medicine, Farnesyltranstransferase, Humans, Enzyme Inhibitors, Molecular Biology, Binding Sites, Diphosphonates, biology, Chemistry, organic chemicals, Organic Chemistry, Geranyltranstransferase, Biological activity, Bisphosphonate, body regions, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein prenylation, lipids (amino acids, peptides, and proteins)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0e84510dab30396ee79474d2271400Test
https://doi.org/10.1016/j.bmc.2010.08.036Test -
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المؤلفون: Kazuyuki Hirano, Masumi Suzui, Kazuhiro Iguchi, Shigeyuki Usui, Yoshiki Tatsuda
المصدر: European Journal of Pharmacology. 627:348-353
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Protein Prenylation, Pamidronate, Metastasis, chemistry.chemical_compound, Cell Line, Tumor, Internal medicine, Enzyme Stability, medicine, Animals, Staurosporine, Protein Kinase Inhibitors, Protein Kinase C, Protein kinase C, Pharmacology, Diphosphonates, business.industry, Activator (genetics), Prostatic Neoplasms, Bone metastasis, Bisphosphonate, medicine.disease, Urokinase-Type Plasminogen Activator, Gene Expression Regulation, Neoplastic, Calphostin C, Endocrinology, chemistry, Cancer cell, Cancer research, business, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860328ea537249ffa6c4f415c7700d1dTest
https://doi.org/10.1016/j.ejphar.2009.10.067Test