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المؤلفون: Meet Patel, William P. Saunders, Melanie J. Blanden, Walter K. Schmidt, Daniel S. Hardgrove, Kiall F. Suazo, James L. Hougland, Emily R. Hildebrandt, Mark D. Distefano
المصدر: Journal of Biological Chemistry. 293:2770-2785
مصطلحات موضوعية: Models, Molecular, Proteomics, 0301 basic medicine, Saccharomyces cerevisiae Proteins, Recombinant Fusion Proteins, Farnesyltransferase, Amino Acid Motifs, Green Fluorescent Proteins, Protein Prenylation, Saccharomyces cerevisiae, Biochemistry, Substrate Specificity, 03 medical and health sciences, Prenylation, Genes, Reporter, Animals, Humans, Enzyme Inhibitors, Databases, Protein, Molecular Biology, Alkyl and Aryl Transferases, biology, Chemistry, C-terminus, Cell Biology, Rats, Protein Subunits, HEK293 Cells, 030104 developmental biology, Microscopy, Fluorescence, Proteome, Enzymology, Protein geranylgeranyltransferase type I, biology.protein, Protein farnesylation, Protein prenylation, Sequence motif
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ababbda007187fd90bf9ffc2570e8d4aTest
https://doi.org/10.1074/jbc.m117.805770Test -
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المؤلفون: Hasina Banu, Hui Li, Rong Liu, Qin Pan, Liang Ma
المصدر: Biomedicine & Pharmacotherapy. 99:169-175
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Uterine Cervical Neoplasms, Antineoplastic Agents, Mice, SCID, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, medicine, Animals, Humans, Doxorubicin, Protein Methyltransferases, Enzyme Inhibitors, Pharmacology, Cervical cancer, Chemotherapy, business.industry, Cysmethynil, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Paclitaxel, chemistry, Apoptosis, 030220 oncology & carcinogenesis, ras Proteins, Cancer research, Protein prenylation, Female, business, Signal Transduction, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d347f809c8533237b905c9fa8de6ed0Test
https://doi.org/10.1016/j.biopha.2018.01.048Test -
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المؤلفون: Raymond J. Hohl, Sarah A. Holstein
المصدر: Current Opinion in Pharmacology. 12:704-709
مصطلحات موضوعية: Farnesyltransferase, Prenyltransferase, Protein Prenylation, aptX, Antineoplastic Agents, Pharmacology, Bioinformatics, Prenylation, Neoplasms, Drug Discovery, medicine, Animals, Guanine Nucleotide Exchange Factors, Humans, Enzyme Inhibitors, biology, Nuclear Proteins, Myeloid leukemia, Dimethylallyltranstransferase, medicine.disease, DNA-Binding Proteins, Clinical trial, Leukemia, Myeloid, Acute, Leukemia, Genes, ras, Drug Design, biology.protein, Protein prenylation, Protein Processing, Post-Translational
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83964bd5059ae285e4cf4201d0cbca23Test
https://doi.org/10.1016/j.coph.2012.06.013Test -
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المؤلفون: Jie Liao, Guang Yu Yang, Haonan Li, Wanying Zhang, Yihe Yang
المصدر: Cancer Letters. 355:273-280
مصطلحات موضوعية: Cancer Research, Aldo-Keto Reductases, Down-Regulation, Mice, Nude, Biology, Reductase, Transfection, medicine.disease_cause, Article, Proto-Oncogene Proteins p21(ras), Mice, Aldehyde Reductase, Cell Line, Tumor, Proto-Oncogene Proteins, Pancreatic cancer, medicine, Animals, Humans, Enzyme Inhibitors, Oleanolic Acid, RNA, Small Interfering, Mice, Inbred BALB C, Aldo-keto reductase, Oncogene, Cell growth, Cadherins, medicine.disease, Xenograft Model Antitumor Assays, Molecular biology, Up-Regulation, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Genes, ras, Oncology, CD18 Antigens, Gene Knockdown Techniques, ras Proteins, Cancer research, Protein prenylation, KRAS, Carcinogenesis, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ef1b40f515a941655d5dc62db0f321Test
https://doi.org/10.1016/j.canlet.2014.09.031Test -
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المؤلفون: H. Peter Spielmann, Arnold Ganser, Douglas A. Andres, Christoph W. M. Reuter, Thangaiah Subramanian, Michael A. Morgan, Fredrick O. Onono
المصدر: Molecular & Cellular Proteomics. 9:742-751
مصطلحات موضوعية: Proteomics, Proteome, Geranylgeranyl pyrophosphate, Farnesyltransferase, Blotting, Western, Protein Prenylation, Farnesyl pyrophosphate, HL-60 Cells, Biology, Models, Biological, Biochemistry, Substrate Specificity, Analytical Chemistry, chemistry.chemical_compound, Geranylgeranylation, Prenylation, Cell Line, Tumor, Farnesyltranstransferase, Humans, Electrophoresis, Gel, Two-Dimensional, Enzyme Inhibitors, Molecular Biology, Aniline Compounds, Staining and Labeling, Research, organic chemicals, Imidazoles, chemistry, biology.protein, Protein farnesylation, Protein prenylation, lipids (amino acids, peptides, and proteins), K562 Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917d6b90284735d27ca8bcf8d957d112Test
https://doi.org/10.1074/mcp.m900597-mcp200Test -
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المؤلفون: Mei-Lin Go, Patrick J. Casey, Wanloo Tan, Jin Zhou, Mei Wang, How Sung Lee, Jolene Leow
المصدر: Journal of Biological Chemistry. 283:18678-18684
مصطلحات موضوعية: Male, Programmed cell death, Indoles, Cell cycle checkpoint, Protein Prenylation, Apoptosis, Biology, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Cell Line, Tumor, Autophagy, medicine, Humans, Protein Methyltransferases, Enzyme Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Cell growth, TOR Serine-Threonine Kinases, Cysmethynil, G1 Phase, Prostatic Neoplasms, Cell Biology, Neoplasm Proteins, Protein Structure, Tertiary, Cell biology, chemistry, Cancer cell, ras Proteins, Protein prenylation, Drug Screening Assays, Antitumor, Carcinogenesis, Protein Kinases, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda5b252ad7a51639d069984a6b6938bTest
https://doi.org/10.1074/jbc.m801855200Test -
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المؤلفون: Yvonne Ibig-Rehm, Gabriele Hofmann, Maxime Magnier, Johann Zimmermann, Marjo Simonen, Daniela Gabriel, Geneviève Albrecht, Valerie Heidinger
المصدر: SLAS Discovery. 13:456-467
مصطلحات موضوعية: Green Fluorescent Proteins, Protein Prenylation, Farnesyl pyrophosphate, Mevalonic Acid, Guanosine, Biology, Transfection, Zoledronic Acid, Biochemistry, Analytical Chemistry, Green fluorescent protein, chemistry.chemical_compound, Methionine, Prenylation, Genes, Reporter, Cell Line, Tumor, Image Processing, Computer-Assisted, Humans, Enzyme Inhibitors, RNA, Small Interfering, Luciferases, chemistry.chemical_classification, Diphosphonates, Cell Membrane, Imidazoles, Reproducibility of Results, Geranyltranstransferase, Dimethylallyltranstransferase, Cell biology, Enzyme, chemistry, High-content screening, ras Proteins, Molecular Medicine, Protein prenylation, lipids (amino acids, peptides, and proteins), Mevalonate pathway, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af4b9bcff2efa54b4344676d598dcdaTest
https://doi.org/10.1177/1087057108318757Test -
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المؤلفون: Prakash Rao Pendyala, Ratna Chakrabarti, Melissa Schreiber, Debopam Chakrabarti, Connie Pham, David A. Fidock, Lawrence Ayong, Jennifer Eatrides, Charles M. Allen
المصدر: Molecular and Biochemical Parasitology. 158:1-10
مصطلحات موضوعية: Farnesyltransferase, Molecular Sequence Data, Plasmodium falciparum, Phosphatase, Protein Prenylation, Protozoan Proteins, Antigens, Protozoan, Protein tyrosine phosphatase, Endoplasmic Reticulum, Prenylation, parasitic diseases, Animals, Farnesyltranstransferase, Amino Acid Sequence, Enzyme Inhibitors, Molecular Biology, Sequence Homology, Amino Acid, biology, Gene Expression Profiling, Endoplasmic reticulum, Membrane Proteins, Apical membrane, biology.organism_classification, Cell biology, Protein Transport, Biochemistry, Vacuoles, biology.protein, Protein prenylation, Parasitology, Protein Tyrosine Phosphatases, Oligopeptides
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48997e3beaed99d47ed2adbd3c82f18bTest
https://doi.org/10.1016/j.molbiopara.2007.11.006Test -
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المصدر: Trends in Pharmacological Sciences. 28:6-13
مصطلحات موضوعية: Pharmacology, business.industry, Protein Prenylation, Mevalonic Acid, Apoptosis, Toxicology, medicine.disease_cause, Anticancer drug, Isoprenoid biosynthesis, Prenylation, Drug Design, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Protein prenylation, Enzyme Inhibitors, Carcinogenesis, business, Clinical evaluation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4583e61319c330a4cfed69c2833374ddTest
https://doi.org/10.1016/j.tips.2006.11.005Test -
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المؤلفون: Trevor C. Stephens, Andrew Hughes, Hilde Rosing, Natalie M. G. M. Appels, Jos H. Beijnen, Jan H.M. Schellens
المصدر: Analytical Biochemistry. 352:33-40
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Bioanalysis, Electrospray, Protein Prenylation, Biophysics, Peptide, Mass spectrometry, Tandem mass spectrometry, Models, Biological, environment and public health, Biochemistry, Proto-Oncogene Proteins p21(ras), Inhibitory Concentration 50, medicine, Farnesyltranstransferase, Humans, Trypsin, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Chromatography, Chemistry, organic chemicals, Farnesyl Transferase Inhibitor, Cell Biology, Deuterium, Peptide Fragments, Recombinant Proteins, Protein prenylation, lipids (amino acids, peptides, and proteins), Chromatography, Liquid, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9791760997eb63581b55eaeaf7937a7cTest
https://doi.org/10.1016/j.ab.2006.02.028Test