Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage
| العنوان: | Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage |
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| المؤلفون: | Anke K. Bergmann, Núria Verdaguer-Dot, José I. Martín-Subero, Christiane Pott, Hendrik G. Stunnenberg, Eva Giné, Wolfram Klapper, Itziar Salaverria, Roser Vilarrasa-Blasi, Joost H.A. Martens, Ivo Gut, Paul Flicek, Avik Datta, Giancarlo Castellano, Ana C. Queirós, Marta Kulis, Alba Navarro, Wyndham H. Wilson, María José Calasanz, Reiner Siebert, Armando López-Guillermo, Nuria Russiñol, Pedro Jares, Elias Campo, Anna Enjuanes, Emanuele Raineri, Renée Beekman, Angelika Merkel, Guillem Clot, Inga Vater, Harmen J.G. van de Werken, Simon Heath, Sílvia Beà, Romina Royo, Martí Duran-Ferrer |
| المساهمون: | Cell biology, Urology |
| المصدر: | Cancer Cell, 30, 5, pp. 806-821 Cancer Cell, 30(5), 806-821. Cell Press Cancer Cell, 30, 806-821 |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Epigenomics, 0301 basic medicine, Cancer Research, mantle cell lymphoma, lymphoma, Lymphoma, Mantle-Cell, Biology, Article, Epigenesis, Genetic, SOXC Transcription Factors, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, hemic and lymphatic diseases, SOX11, Humans, Cell Lineage, Computer Simulation, Epigenetics, DNA looping, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), RNA-Directed DNA Methylation, Molecular Biology, B-Lymphocytes, High-Throughput Nucleotide Sequencing, Methylation, Cell Biology, DNA Methylation, Molecular biology, Chromatin, ChIP-seq, Gene Expression Regulation, Neoplastic, Enhancer Elements, Genetic, 030104 developmental biology, Differentially methylated regions, Oncology, 030220 oncology & carcinogenesis, DNA methylation, Disease Progression, chromatin, Illumina Methylation Assay, enhancer, whole-genome bisulfite sequencing |
| الوصف: | SummaryWe analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We identified two MCL subgroups, respectively carrying epigenetic imprints of germinal-center-inexperienced and germinal-center-experienced B cells, and we found that DNA methylation profiles during lymphomagenesis are largely influenced by the methylation dynamics in normal B cells. An integrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cases, including a distant enhancer showing de novo looping to the MCL oncogene SOX11. Finally, we observed that the magnitude of DNA methylation changes per case is highly variable and serves as an independent prognostic factor for MCL outcome. |
| وصف الملف: | application/pdf |
| تدمد: | 1535-6108 |
| DOI: | 10.1016/j.ccell.2016.09.014 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47009c6206375c77f9c779e79533b226Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....47009c6206375c77f9c779e79533b226 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15356108 |
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| DOI: | 10.1016/j.ccell.2016.09.014 |