Melatonin: A pleiotropic molecule regulating inflammation
| العنوان: | Melatonin: A pleiotropic molecule regulating inflammation |
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| المؤلفون: | Flavia Radogna, Lina Ghibelli, Marc Diederich |
| المساهمون: | Dipartimento di Biologia, Università degli Studi di Roma Tor Vergata [Roma], Hôpital Kirchberg, Hôpital Kirchberg [Luxembourg] |
| المصدر: | Biochemical Pharmacology Biochemical Pharmacology, Elsevier, 2010, 80 (12), pp.1844. ⟨10.1016/j.bcp.2010.07.041⟩ |
| بيانات النشر: | Elsevier BV, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | endocrine system, medicine.medical_specialty, Cell Survival, Anti-Inflammatory Agents, Apoptosis, Inflammation, Biology, Pineal Gland, Biochemistry, NF-κB, Antioxidants, Melatonin, 03 medical and health sciences, Paracrine signalling, Pineal gland, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Leukocytes, medicine, Animals, Humans, Reactive Oxygen Species, Oxidative Stress, Signal Transduction, Arachidonic Acid, Autocrine signalling, 030304 developmental biology, Pharmacology, 0303 health sciences, Settore BIO/13, lipoxygenase, Cell biology, Endocrinology, medicine.anatomical_structure, chemistry, medicine.symptom, Signal transduction, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Hormone, medicine.drug |
| الوصف: | International audience; Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocytes respond to melatonin in a circadian fashion; on the other side, leukocytes are able to synthesize melatonin by themselves. With its endocrine and paracrine effects, melatonin differentially modulates pro-inflammatory enzymes, controls production of inflammatory mediators such as cytokines and leukotrienes and regulates the lifespan of leukocytes by interfering with apoptotic processes. Moreover, its potent anti-oxidant ability allows scavenging of oxidative stress in the inflamed tissues. The interesting timing of pro- and anti-inflammatory effects, such as those affecting lipoxygenase activity, suggests that melatonin might promote early phases of inflammation on one hand and contribute to its attenuation on the other hand, in order to avoid complications of chronic inflammation. This review aims at giving a comprehensive overview of the various inflammatory pathways regulated by this pleiotropic hormone. |
| تدمد: | 0006-2952 1873-2968 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2789b0815c16246d522cb9d1a5923143Test https://doi.org/10.1016/j.bcp.2010.07.041Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2789b0815c16246d522cb9d1a5923143 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00062952 18732968 |
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