التفاصيل البيبلوغرافية
| العنوان: |
MiR-34a-5p mediates sevoflurane preconditioning induced inhibition of hypoxia/reoxygenation injury through STX1A in cardiomyocytes. |
| المؤلفون: |
Wenlan, Li1, Zhongyuan, Xia1 xiazhongyuanwu@163.com, Shaoqing, Lei1, Liying, Zhan1, Bo, Zhao1, Min, Liu1 |
| المصدر: |
Biomedicine & Pharmacotherapy. Jun2018, Vol. 102, p153-159. 7p. |
| مصطلحات موضوعية: |
*CARDIOVASCULAR diseases, *SEVOFLURANE, *SYNTAXINS, *MICRORNA, *HEART cells, *WOUNDS & injuries |
| مستخلص: |
Anesthetic preconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders cardio injury. Sevoflurane preconditioning has been shown to exhibit cardio protective effect on hypoxia/reoxygenation (H/R) injury, but the underlying mechanism is unclear. Syntaxin 1A (STX1A), an important regulator in cardio disease, was predicted to be the target gene of microRNA-34a-5p (miR-34a-5p). The current research was designed to delineate the role of miR-34a-5p in regulating sevoflurane preconditioning in cardiomyocytes injury. In this study, the results demonstrated that the expression of STX1A was significantly increased, while miR-34a-5p was dramatically decreased in sev-preconditioning H9c2 cells as compared with cells only under H/R stimulation. Moreover, miR-34a-5p regulated the protective effect of sev-preconditioning in injured H9c2 cells by mediating cell proliferation and cell apoptosis. Additionally, the luciferase report confirmed the targeting reaction between STX1A and miR-34a-5p. Taken together, our study suggested that miR-34a-5p regulated sev-preconditioning induced inhibition of hypoxia/reoxygenation injury through mediating STX1A, provided a potential therapeutic target for anesthetic protection in cardio disease. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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