التفاصيل البيبلوغرافية
| العنوان: |
A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling. |
| المؤلفون: |
Taiga Maemoto1, Yuichi Kitai1 yu-kitai@pharm.hokudai.ac.jp, Runa Takahashi1, Haruka Shoji1, Shunsuke Yamada1, Shiho Takei2, Daiki Ito2, Ryuta Muromoto1, Jun-ichi Kashiwakura1, Haruka Handa3, Ari Hashimoto3, Shigeru Hashimoto4, Toyoyuki Ose2, Kenji Oritani5, Tadashi Matsuda1 tmatsuda@pharm.hokudai.ac.jp |
| المصدر: |
Journal of Biological Chemistry. Jan2023, Vol. 299 Issue 1, p1-8. 8p. |
| مصطلحات موضوعية: |
*PEPTIDES, *ANDROGEN receptors, *CANCER invasiveness, *EPIDERMAL growth factor receptors, *ADAPTOR proteins, *CANCER cell proliferation |
| مستخلص: |
Signal-transducing adaptor family member-2 (STAP-2) is an adaptor protein that regulates various intracellular signals. We previously demonstrated that STAP-2 binds to epidermal growth factor receptor (EGFR) and facilitates its stability and activation of EGFR signaling in prostate cancer cells. Inhibition of this interaction may be a promising direction for cancer treatment. Here, we found that 2D5 peptide, a STAP- 2--derived peptide, blocked STAP-2--EGFR interactions and suppressed EGFR-mediated proliferation in several cancer cell lines. 2D5 peptide inhibited tumor growth of human prostate cancer cell line DU145 and human lung cancer cell line A549 in murine xenograft models. Additionally, we determined that EGFR signaling and its stability were decreased by 2D5 peptide treatment during EGF stimulation. In conclusion, our study shows that 2D5 peptide is a novel anticancer peptide that inhibits STAP-2--mediated activation of EGFR signaling and suppresses prostate and lung cancer progression. [ABSTRACT FROM AUTHOR] |
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