المؤلفون: Gill, Pelvender, Chen, Jane J., Boardman, Phil, Patel, Nilay, Browning, Lisa, Roberts, Ian S. D., Verrill, Clare

المصدر: Diagnostic Histopathology; Aug2014, Vol. 20 Issue 8, p329-332, 4p

مستخلص: This case illustrates heterotopic bone formation in a patient with cystic nephroma (CN) of the kidney. Renal CN may be difficult to discern clinically and radiologically from 'Multilocular Cystic Renal Cell Neoplasm of Low Malignant Potential (MCRCNLMP)' or a clear cell renal cell carcinoma with extensive cystic change. In both of the latter, dystrophic calcification or ossification is not uncommon. The formation of heterotopic bone in CN/MEST is rare and should not be confused with sarcomatous transformation on histology. Radiologically, the presence of central calcification increases the suspicion of a cystic renal cell carcinoma, a potential diagnostic pitfall. [ABSTRACT FROM AUTHOR]

: Copyright of Diagnostic Histopathology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Herrington, William G., Talbot, Denis C., Lahn, Michael M., Brandt, John T., Callies, Sophie, Nagle, Ray, Winearls, Christopher G., Roberts, Ian S. D.

المصدر: American Journal of Kidney Diseases; Feb2011, Vol. 57 Issue 2, p300-303, 4p, 1 Diagram, 1 Graph

مستخلص: A 57-year-old man with metastatic melanoma was treated with the survivin inhibitor and antisense oligonucleotide LY2181308 as part of a First-in-Human Dose trial. After 18 months of treatment, he developed kidney injury and the treatment was discontinued. At 9 months and before the development of kidney injury, LY2181308 concentrations were 8- to 10-fold higher relative to median predicted values, but within the targeted exposure considered to be safe. However, at 17 months, 28 days after stopping LY2181308 therapy, LY2181308 concentration exceeded the predicted range by 38-fold. His decreased kidney function was slow to improve after stopping treatment. A kidney biopsy showed signs of acute tubular injury with regeneration. Complete recovery of kidney function occurred 6 months after treatment was stopped. The relationship between high exposures and slow LY2181308 clearance with the gradual improvement in kidney function after stopping the antisense treatment suggests that the oligonucleotide was related to the kidney injury. Based on this case report, kidney function should be monitored frequently in patients receiving long-term treatment with antisense oligonucleotides that specifically target survivin, particularly when they receive concomitant angiotensin-converting enzyme inhibitors or nonsteroidal anti-inflammatory drugs. [ABSTRACT FROM AUTHOR]

: Copyright of American Journal of Kidney Diseases is the property of W B Saunders and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Roberts, Ian S. D.¹ ian.roberts@orh.nhs.uk, Cook, H. Terence², Troyanov, Stéphan³, Alpers, Charles E.⁴, Amore, Alessandro⁵, Barratt, Jonathan⁶, Berthoux, Francois⁷, Bonsib, Stephen⁸, Bruijn, Jan A.⁹, Cattran, Daniel C.¹⁰, Coppo, Rosanna⁵, D'Agati, Vivette¹¹, D'Amico, Giuseppe¹², Emancipator, Steven¹³, Emma, Francesco¹⁴, Feehally, John⁶, Ferrario, Franco¹⁵, Fervenza, Fernando C.¹⁶, Florquin, Sandrine¹⁷, Fogo, Agnes¹⁸

المصدر: Kidney International. Sep2009, Vol. 76 Issue 5, p546-556. 11p. 2 Color Photographs, 6 Charts.

مصطلحات موضوعية: *IMMUNOGLOBULIN A, *KIDNEY diseases, *PATHOLOGISTS, *PREVENTIVE medicine, *IGA glomerulonephritis

مستخلص: Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glomerular disease, IgA nephropathy, in which renal pathologists first undertook extensive iterative work to define pathologic variables with acceptable inter-observer reproducibility. Where groups of such features closely correlated, variables were further selected on the basis of least susceptibility to sampling error and ease of scoring in routine practice. This process identified six pathologic variables that could then be used to interrogate prognostic significance independent of the clinical data in IgA nephropathy (described in the accompanying article). These variables were (1) mesangial cellularity score; percentage of glomeruli showing (2) segmental sclerosis, (3) endocapillary hypercellularity, or (4) cellular/fibrocellular crescents; (5) percentage of interstitial fibrosis/tubular atrophy; and finally (6) arteriosclerosis score. Results for interobserver reproducibility of individual pathological features are likely applicable to other glomerulonephritides, but it is not known if the correlations between variables depend on the specific type of glomerular pathobiology. Variables identified in this study withstood rigorous pathology review and statistical testing and we recommend that they become a necessary part of pathology reports for IgA nephropathy. Our methodology, translating a strong evidence-based dataset into a working format, is a model for developing classifications of other types of renal disease.Kidney International (2009) 76, 546–556; doi:10.1038/ki.2009.168; published online 1 July 2009 [ABSTRACT FROM AUTHOR]

المؤلفون: Chong L, Baikunje S, Poller DN, Roberts IS, Venkat-Raman G, Chong, Lin, Baikunje, Shashidhar, Poller, David N, Roberts, Ian S D, Venkat-Raman, Gopalakrishnan

المصدر: American Journal of Kidney Diseases; Aug2008, Vol. 52 Issue 2, p366-369, 4p

المؤلفون: Cook, Terry¹, Roberts, Ian S D², Feehally, John³, Barratt, Jonathan³

المصدر: Kidney International. Nov2014, Vol. 86 Issue 5, p1059-1059. 1p.

مصطلحات موضوعية: *IMMUNOGLOBULIN A, *IGA glomerulonephritis, *KIDNEY diseases

مستخلص: A letter to the editor is presented in response to an article about the Oxford Classification of IgA Nephropathy as evidence-based classification of glomerular disease.

المؤلفون: Roberts, Ian S. D.¹ ian.roberts@orh.nhs.uk, Cook, H. Terence¹

المصدر: Kidney International. Dec2009, Vol. 76 Issue 11, p1207-1207. 1p.

مصطلحات موضوعية: *LETTERS to the editor, *KIDNEY diseases

مستخلص: A response by Ian S. D. Roberts and H. Terence Cook to a letter to the editor about their article "Oxford classification of IgA nephropathy," which was published in a previous issue, is presented.

المؤلفون: Biers, Suzanne M.¹, Sullivan, Mark E.¹, Roberts, Ian S. D.², Noble, Jeremy G.¹

المصدر: Urology. Feb2004, Vol. 63 Issue 2, p380. 3p.

مصطلحات موضوعية: *PROSTATE cancer, *AUTOPSY, *THROMBOSIS, *ANGIOPLASTY

مستخلص: We report a case of acute renal failure in a man with medically treated advanced prostate carcinoma. Imaging suggested renal tract obstruction as the cause; however, the patient failed to respond to treatment with dialysis and bilateral nephrostomy insertion. Postmortem examination revealed the renal failure to have been due to severe thrombotic microangiopathy. [Copyright &y& Elsevier]

المؤلفون: Coppo, Rosanna¹, Troyanov, Stéphan², Bellur, Shubha³, Cattran, Daniel⁴, Cook, H Terence⁵, Feehally, John⁶, Roberts, Ian S D³, Morando, Laura, Camilla, Roberta, Tesar, Vladimir, Lunberg, Sigrid, Gesualdo, Loreto, Emma, Francesco, Rollino, Cristiana, Amore, Alessandro, Praga, Manuel, Feriozzi, Sandro, Segoloni, Giuseppe, Pani, Antonello, Cancarini, Giovanni

المصدر: Kidney International. Oct2014, Vol. 86 Issue 4, p828-836. 9p.

مصطلحات موضوعية: *IGA glomerulonephritis, *IMMUNOSUPPRESSIVE agents, *GLOMERULAR filtration rate, *IMMUNOSUPPRESSION, *PROTEINURIA

مستخلص: The Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors of outcome. Whether it applies to individuals excluded from the original study and how therapy influences the predictive value of pathology remain uncertain. The VALIGA study examined 1147 patients from 13 European countries that encompassed the whole spectrum of IgAN. Over a median follow-up of 4.7 years, 86% received renin-angiotensin system blockade and 42% glucocorticoid/immunosuppressive drugs. M, S, and T lesions independently predicted the loss of estimated glomerular filtration rate (eGFR) and a lower renal survival. Their value was also assessed in patients not represented in the Oxford cohort. In individuals with eGFR less than 30 ml/min per 1.73 m2, the M and T lesions independently predicted a poor survival. In those with proteinuria under 0.5 g/day, both M and E lesions were associated with a rise in proteinuria to 1 or 2 g/day or more. The addition of M, S, and T lesions to clinical variables significantly enhanced the ability to predict progression only in those who did not receive immunosuppression (net reclassification index 11.5%). The VALIGA study provides a validation of the Oxford classification in a large European cohort of IgAN patients across the whole spectrum of the disease. The independent predictive value of pathology MEST score is reduced by glucocorticoid/immunosuppressive therapy. [ABSTRACT FROM AUTHOR]

المؤلفون: Coppo, Rosanna¹ rosanna.coppo@unito.it, Troyanov, Stéphan², Camilla, Roberta¹, Hogg, Ronald J.³, Cattran, Daniel C.⁴, Cook, H. Terence⁵, Feehally, John⁶, Roberts, Ian S. D.⁷, Amore, Alessandro¹, Alpers, Charles E.⁸, Barratt, Jonathan⁶, Berthoux, Francois⁹, Bonsib, Stephen¹⁰, Bruijn, Jan A.¹¹, D'Agati, Vivette¹², D'Amico, Giuseppe¹³, Emancipator, Steven N.¹⁴, Emma, Francesco¹⁵, Ferrario, Franco¹⁶, Fervenza, Fernando C.¹⁷

المصدر: Kidney International. May2010, Vol. 77 Issue 10, p921-927. 7p. 3 Charts, 3 Graphs.

مصطلحات موضوعية: *KIDNEY diseases, *URINALYSIS, *URINARY organ diseases, *BIOPSY, *PROTEINURIA, *HEMATURIA, *RETROSPECTIVE studies

مستخلص: To study the predictive value of biopsy lesions in IgA nephropathy in a range of patient ages we retrospectively analyzed the cohort that was used to derive a new classification system for IgA nephropathy. A total of 206 adults and 59 children with proteinuria over 0.5 g/24 h/1.73 m2 and an eGFR of stage-3 or better were followed for a median of 69 months. At the time of biopsy, compared with adults children had a more frequent history of macroscopic hematuria, lower adjusted blood pressure, and higher eGFR but similar proteinuria. Although their outcome was similar to that of adults, children had received more immunosuppressants and achieved a lower follow-up proteinuria. Renal biopsies were scored for variables identified by an iterative process as reproducible and independent of other lesions. Compared with adults, children had significantly more mesangial and endocapillary hypercellularity, and less segmental glomerulosclerosis and tubulointerstitial damage, the four variables previously identified to predict outcome independent of clinical assessment. Despite these differences, our study found that the cross-sectional correlation between pathology and proteinuria was similar in adults and children. The predictive value of each specific lesion on the rate of decline of renal function or renal survival in IgA nephropathy was not different between children and adults. [ABSTRACT FROM AUTHOR]

المؤلفون: Cattran, Daniel C.¹, Coppo, Rosanna², Cook, H. Terence³, Feehally, John⁴ jf27@le.ac.uk, Roberts, Ian S. D.⁵, Troyanov, Stéphan⁶, Alpers, Charles E.⁷, Amore, Alessandro², Barratt, Jonathan⁴, Berthoux, Francois⁸, Bonsib, Stephen⁹, Bruijn, Jan A.¹⁰, D'Agati, Vivette¹¹, D'Amico, Giuseppe¹², Emancipator, Steven¹³, Emma, Francesco¹⁴, Ferrario, Franco¹⁵, Fervenza, Fernando C.¹⁶, Florquin, Sandrine¹⁷, Fogo, Agnes¹⁸

المصدر: Kidney International. Sep2009, Vol. 76 Issue 5, p534-545. 12p. 9 Charts, 1 Graph.

مصطلحات موضوعية: *IMMUNOGLOBULIN A, *KIDNEY diseases, *BIOPSY, *CLINICAL pathology, *MEDICAL personnel

مستخلص: IgA nephropathy is the most common glomerular disease worldwide, yet there is no international consensus for its pathological or clinical classification. Here a new classification for IgA nephropathy is presented by an international consensus working group. The goal of this new system was to identify specific pathological features that more accurately predict risk of progression of renal disease in IgA nephropathy, thus enabling both clinicians and pathologists to improve individual patient prognostication. In a retrospective analysis, sequential clinical data were obtained on 265 adults and children with IgA nephropathy who were followed for a median of 5 years. Renal biopsies from all patients were scored by pathologists blinded to the clinical data for pathological variables identified as reproducible by an iterative process. Four of these variables: (1) the mesangial hypercellularity score, (2) segmental glomerulosclerosis, (3) endocapillary hypercellularity, and (4) tubular atrophy/interstitial fibrosis were subsequently shown to have independent value in predicting renal outcome. These specific pathological features withstood rigorous statistical analysis even after taking into account all clinical indicators available at the time of biopsy as well as during follow-up. The features have prognostic significance and we recommended they be taken into account for predicting outcome independent of the clinical features both at the time of presentation and during follow-up. The value of crescents was not addressed due to their low prevalence in the enrolled cohort.Kidney International (2009) 76, 534–545; doi:10.1038/ki.2009.243; published online 1 July 2009 [ABSTRACT FROM AUTHOR]