دورية أكاديمية
Infectious events in patients treated with immune checkpoint inhibitors, chimeric antigen receptor T cells and Bi-specific T-cell engagers: a review of registration studies
| العنوان: | Infectious events in patients treated with immune checkpoint inhibitors, chimeric antigen receptor T cells and Bi-specific T-cell engagers: a review of registration studies |
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| المؤلفون: | Andrea Lombardi, Atil Saydere, Riccardo Ungaro, Giorgio Bozzi, Giulia Viero, Alessandra Bandera, Andrea Gori, Mario U. Mondelli |
| المساهمون: | A. Lombardi, A. Saydere, R. Ungaro, G. Bozzi, G. Viero, A. Bandera, A. Gori, M.U. Mondelli |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Bi-specific T-cell engager, cancer treatment, chimeric antigen receptor T cell, immune checkpoint inhibitor, infections, Settore MED/17 - Malattie Infettive |
| الوصف: | Background: Immunological treatments (immune checkpoint inhibitors, chimeric antigen receptor T cells, Bi-specific T-cell engagers) have deeply changed the treatment of several cancers. However, the impact of these treatments on the risk of developing infections has not been completely ascertained, yet. Methods: We reviewed all the registration studies of currently approved immune checkpoint inhibitors (ICIs), chimeric antigen receptor T cells (CAR-T cells) and Bi-specific T-cell engagers (BiTEs) to collect all the reported infections. For each drug, we have generated a report with the infections occurring in at least 10% of the patients enrolled. Results: The most frequently reported infections involving ICIs-treated patients involved the respiratory tract, including nasopharyngitis, upper respiratory tract infections and pneumonia, and the urinary tract. Among those treated with CAR-T cells, were frequently reported the incidence of unspecified infections and infestations, bacterial and viral infections. In patients treated with BiTEs, nasopharyngitis, pneumonia and device-related infections were the most frequently reported conditions. Conclusions: A wide range of infections are reported in registration studies and clinical trials of ICIs, CAR-T cells and BiTEs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35429642; info:eu-repo/semantics/altIdentifier/wos/WOS:000806188800014; volume:120; firstpage:77; lastpage:82; numberofpages:6; journal:INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES; http://hdl.handle.net/2434/925331Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85129468726 |
| DOI: | 10.1016/j.ijid.2022.04.022 |
| الإتاحة: | https://doi.org/10.1016/j.ijid.2022.04.022Test http://hdl.handle.net/2434/925331Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.21CF8AEA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijid.2022.04.022 |
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