التفاصيل البيبلوغرافية
| العنوان: |
Early Outcomes of Multivisceral Transplant Using Hepatitis C–Positive Donors. |
| المؤلفون: |
McMaster, William G., Rahaman, Zakiur M., Shipe, Maren E., Quintana, Eric N., Sandhaus, Emily M., Smith, Sarah S., Crockett, Jerod E., Forbes, Rachel C., Schlendorf, Kelly H., Shah, Ashish S. |
| المصدر: |
Annals of Thoracic Surgery; Aug2021, Vol. 112 Issue 2, p511-518, 8p |
| مستخلص: |
In the era of direct-acting antiviral therapies, hepatitis C–positive organs offer a strategy to expand the donor pool. Heart failure patients with concomitant renal insufficiency benefit from combined heart/kidney transplant. In 2017, we began utilizing organs from hepatitis C donors for heart/kidney transplants. Characteristics and outcomes of heart/kidney transplants were collected at our institution from 2012 through 2019. We determined patient cohorts by donor hepatitis C antibody status, antibody positive (HCV+) vs antibody negative (HCV-). Outcomes of interest include survival, postoperative allograft function, and waitlist time. Summary and descriptive statistics, as well as survival analyses, were performed. Thirty-nine patients underwent heart/kidney transplantation from 2012-2019. Twelve patients received HCV+ organs, and 27 patients received HCV- organs with minimal differences in donor and recipient cohort characteristics. Recipients who consented to receive HCV+ organs had a shorter median waitlist time. HCV+ and HCV- groups had similar perioperative and early postoperative cardiac function and similar rates of delayed renal graft function. HCV+ recipients demonstrated higher creatinine levels at 3 months posttransplant compared with HCV- recipients, but by 1-year post-transplant, creatinine levels in both groups were similar. The groups had similar 30-day and 1-year survival. This study is a single-center series of heart/kidney transplant using HCV+ donors. When the potential increased risk of early postoperative renal dysfunction is balanced against similar survival and decreased waitlist time, the results suggest that HCV+ donors are an important source of transplantable organs for heart/kidney transplantation. [ABSTRACT FROM AUTHOR] |
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