يعرض 1 - 6 نتائج من 6 نتيجة بحث عن '"Norris, Daniel A"', وقت الاستعلام: 1.83s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides.

    المؤلفون: Geary, Richard S.1 rgeary@isisph.com, Norris, Daniel1, Yu, Rosie1, Bennett, C. Frank1

    المصدر: Advanced Drug Delivery Reviews. Jun2015, Vol. 87, p46-51. 6p.

    مصطلحات موضوعية: *PHARMACOKINETICS, *ANTISENSE peptides, *OLIGONUCLEOTIDES, *BIOAVAILABILITY, *GLOMERULAR filtration rate, *BLOOD proteins, *PLASMA stability


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  2. 2
    دورية أكاديمية
    Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial.

    المؤلفون: Thornton, Charles A1 (AUTHOR), Moxley III, Richard Thomas1 (AUTHOR), Eichinger, Katy1 (AUTHOR), Heatwole, Chad2 (AUTHOR), Mignon, Laurence3 (AUTHOR), Arnold, W David4 (AUTHOR), Ashizawa, Tetsuo5 (AUTHOR), Day, John W6 (AUTHOR), Dent, Gersham7 (AUTHOR), Tanner, Matthew K1 (AUTHOR), Duong, Tina6 (AUTHOR), Greene, Ericka P8 (AUTHOR), Herbelin, Laura9 (AUTHOR), Johnson, Nicholas E10 (AUTHOR), King, Wendy4 (AUTHOR), Kissel, John T4 (AUTHOR), Leung, Doris G11 (AUTHOR), Lott, Donovan J12 (AUTHOR), Norris, Daniel A13 (AUTHOR), Pucillo, Evan M10 (AUTHOR)

    المصدر: Lancet Neurology. Mar2023, Vol. 22 Issue 3, p218-228. 11p.

    مصطلحات موضوعية: *MYOTONIA atrophica, *TRINUCLEOTIDE repeats, *GAIN-of-function mutations, *SUBCUTANEOUS injections, *PROTEIN kinases, *HYPERCOAGULATION disorders

    الشركة/الكيان: IONIS Pharmaceuticals Inc. 361949092 ISIS


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  3. 3
    دورية أكاديمية
    An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study.

    المؤلفون: Miller, Timothy M1 millert@neuro.wustl.edu, Pestronk, Alan1, David, William2, Rothstein, Jeffrey3, Simpson, Ericka4, Appel, Stanley H4, Andres, Patricia L2, Mahoney, Katy2, Allred, Peggy2, Alexander, Katie5, Ostrow, Lyle W3, Schoenfeld, David2, Macklin, Eric A2, Norris, Daniel A5, Manousakis, Georgios1, Crisp, Matthew1, Smith, Richard6, Bennett, C Frank5, Bishop, Kathie M5, Cudkowicz, Merit E2

    المصدر: Lancet Neurology. May2013, Vol. 12 Issue 5, p435-442. 8p.

    مصطلحات موضوعية: *GENETICS of amyotrophic lateral sclerosis, *AMYOTROPHIC lateral sclerosis, *DOSE-response relationship in biochemistry, *INJECTIONS, *HEALTH outcome assessment, *PLACEBOS, *RESEARCH funding, *SAFETY, *SUPEROXIDE dismutase, *RANDOMIZED controlled trials, *TREATMENT effectiveness, *BLIND experiment, *INVESTIGATIONAL drugs, *PHARMACODYNAMICS


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  4. 4
    دورية أكاديمية
    Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

    المؤلفون: Ruebsam, Frank fruebsam@anadyspharma.com, Sun, Zhongxiang1, Ayida, Benjamin K.1, Webber, Stephen E.1, Zhou, Yuefen1, Zhao, Qiang1, Kissinger, Charles R.1, Showalter, Richard E.1, Shah, Amit M.1, Tsan, Mei1, Patel, Rupal1, LeBrun, Laurie A.1, Kamran, Ruhi1, Sergeeva, Maria V.1, Bartkowski, Darian M.1, Nolan, Thomas G.1, Norris, Daniel A.1, Kirkovsky, Leo1

    المصدر: Bioorganic & Medicinal Chemistry Letters. Sep2008, Vol. 18 Issue 18, p5002-5005. 4p.

    مصطلحات موضوعية: *RNA polymerases, *HEPATITIS C virus, *PYRIDAZINES, *MICROSOMES, *LIVER, *PHARMACEUTICAL chemistry


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  5. 5
    دورية أكاديمية
    Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

    المؤلفون: Li, Lian-Sheng1, Zhou, Yuefen yuefen.zhou@gmail.com, Murphy, Douglas E.1, Stankovic, Nebojsa1, Zhao, Jingjing1, Dragovich, Peter S.1, Bertolini, Thomas1, Sun, Zhongxiang1, Ayida, Benjamin1, Tran, Chinh V.1, Ruebsam, Frank1, Webber, Stephen E.1, Shah, Amit M.1, Tsan, Mei1, Showalter, Richard E.1, Patel, Rupal1, LeBrun, Laurie A.1, Bartkowski, Darian M.1, Nolan, Thomas G.1, Norris, Daniel A.1

    المصدر: Bioorganic & Medicinal Chemistry Letters. Jun2008, Vol. 18 Issue 11, p3446-3455. 10p.

    مصطلحات موضوعية: *PYRIDAZINONES, *HEPATITIS C virus, *NUCLEOSIDES, *RNA polymerases


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  6. 6
    دورية أكاديمية
    Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties

    المؤلفون: Sergeeva, Maria V.1, Zhou, Yuefen yuefen.zhou@gmail.com, Bartkowski, Darian M.1, Nolan, Thomas G.1, Norris, Daniel A.1, Okamoto, Ellen1, Kirkovsky, Leo1, Kamran, Ruhi1, LeBrun, Laurie A.1, Tsan, Mei1, Patel, Rupal1, Shah, Amit M.1, Lardy, Matthew1, Gobbi, Alberto1, Li, Lian-Sheng1, Zhao, Jingjing1, Bertolini, Thomas1, Stankovic, Nebojsa1, Sun, Zhongxiang1, Murphy, Douglas E.1

    المصدر: Bioorganic & Medicinal Chemistry Letters. Jun2008, Vol. 18 Issue 11, p3421-3426. 6p.

    مصطلحات موضوعية: *PYRIDAZINONES, *HEPATITIS C virus, *DRUG metabolism, *PHARMACOKINETICS


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