المؤلفون: Ferreira, David^1,2 (AUTHOR) dferreira@chu-besancon.fr, Ludes, Pierre-Olivier³ (AUTHOR), Diemunsch, Pierre³ (AUTHOR), Noll, Eric³ (AUTHOR), Torp, Klaus D.⁴ (AUTHOR), Meyer, Nicolas^2,5 (AUTHOR)

المصدر: BJA: The British Journal of Anaesthesia. Feb2021, Vol. 126 Issue 2, p550-555. 6p.

مصطلحات موضوعية: *CLINICAL trials monitoring, *SEQUENTIAL analysis, *RANDOM numbers, *PROBABILITY theory, *EXPERIMENTAL design, *STATISTICS, *CLINICAL trials, *PRODUCT design, *TREATMENT effectiveness, *ENDOSCOPES, *STATISTICAL models, *DATA analysis, *LARYNGOSCOPY

مستخلص: Background: Bayesian methods, with the predictive probability (PredP), allow multiple interim analyses with interim posterior probability (PostP) computation, without the need to correct for multiple looks at the data. The objective of this paper was to illustrate the use of PredP by simulating a sequential analysis of a clinical trial.Methods: We used data from the Laryngobloc trial that planned to include 480 patients to demonstrate the equivalence of success between a laryngoscopy performed with the Laryngobloc® device and a control device. A crossover Bayesian design was used. The success rates of the two laryngoscopy devices were compared. Interim analyses, computed from random numbers of subjects, were simulated.Results: The PostP of equivalence rapidly reached the predefined bound of 0.95. The PredP computed with an equivalence margin of 10% reached the efficacy bound between 352 and 409 of the 480 included patients. If a frequentist analysis had been made on the basis of 217 out of 480 subjects, the study would have been prematurely stopped for equivalence. The PredP indicated that this result was nonetheless unstable and that the equivalence was, thus far, not guaranteed.Conclusions: Based on these interim analyses, we can conclude with a sufficiently high probability that the equivalence would have been met on the primary outcome before the predetermined end of this particular trial. If a Bayesian approach using PredP had been used, it would have allowed an early termination of the trial by reducing the calculated sample size by 15-20%. [ABSTRACT FROM AUTHOR]

المؤلفون: Demumieux, François¹ (AUTHOR), Ludes, Pierre-Olivier¹ (AUTHOR), Diemunsch, Pierre^1,2,3 (AUTHOR), Bennett-Guerrero, Elliott⁴ (AUTHOR), Lujic, Marko¹ (AUTHOR), Lefebvre, François⁵ (AUTHOR), Noll, Eric^1,2,3 (AUTHOR) eric.noll@chru-strasbourg.fr

المصدر: BJA: The British Journal of Anaesthesia. Jun2020, Vol. 124 Issue 6, p761-767. 7p.

مصطلحات موضوعية: *CRONBACH'S alpha, *CLASSICAL test theory, *MEASURING instruments, *PERCEIVED Stress Scale, *LENGTH of stay in hospitals, *ANESTHESIA, *HEALTH status indicators, *PSYCHOMETRICS, *QUALITY of life, *TRANSLATIONS, RESEARCH evaluation

مصطلحات جغرافية: FRANCE

مستخلص: Background: Quality of recovery is an important component of perioperative health status. The 15-item Quality of Recovery (QoR-15) scale is a validated multidimensional questionnaire that measures postoperative quality of recovery. The aim of this study was to translate and assess the psychometric properties of a French version of the QoR-15 scale (QoR-15F) to measure postoperative recovery in French-speaking patients.Methods: After translation into French of the original English version of the QoR-15 scale, psychometric validation of the QoR-15F scale to measure postoperative quality of recovery was performed. This psychometric validation included validity, reliability, responsiveness, and feasibility. The QoR-15F scale was administered before operation and on Postoperative day 1 in French-speaking patients. Patient-perceived global recovery assessment was measured at Postoperative day 1 using a VAS.Results: We enrolled 150 patients, and 144 completed the study protocol. The completion rate of administered questionnaires was 100%. Pearson (r) correlation between postoperative QoR-15F and the global recovery assessment by the patient was 0.60 (P<0.0001). As expected, there was a significant negative correlation between QoR-15F score and duration of surgery (r=-0.29; P<0.01), duration of PACU stay (r=-0.21; P=0.01), and duration of hospital stay (r=-0.34; P<0.01). Cronbach's alpha was 0.81, split-half alpha was 0.83, and the global test-retest intra-class coefficient was 0.98 (0.95-0.99).Conclusions: The QoR-15F is a valid and reliable tool to measure postoperative quality of recovery in French-speaking patients. The psychometric properties to measure postoperative quality of recovery were similar to the seminal English version.Clinical Trial Registration: NCT03578068. [ABSTRACT FROM AUTHOR]

المؤلفون: Danion, François¹ (AUTHOR), Duval, Céline² (AUTHOR), Séverac, François^3,4 (AUTHOR), Bachellier, Philippe⁵ (AUTHOR), Candolfi, Ermanno^1,6,7 (AUTHOR), Castelain, Vincent⁸ (AUTHOR), Clere-Jehl, Raphaël^8,9 (AUTHOR), Denis, Julie^6,7 (AUTHOR), Dillenseger, Laurence¹⁰ (AUTHOR), Epailly, Eric¹¹ (AUTHOR), Gantzer, Justine¹² (AUTHOR), Guffroy, Blandine^2,13 (AUTHOR), Hansmann, Yves¹ (AUTHOR), Herbrecht, Jean-Etienne⁸ (AUTHOR), Letscher-Bru, Valérie^6,7 (AUTHOR), Leyendecker, Pierre¹⁴ (AUTHOR), Le Van Quyen, Pauline¹⁵ (AUTHOR), Ludes, Pierre-Olivier¹⁶ (AUTHOR), Morel, Guillaume⁸ (AUTHOR), Moulin, Bruno^9,17 (AUTHOR)

المصدر: Clinical Microbiology & Infection. Nov2021, Vol. 27 Issue 11, p1644-1651. 8p.

مصطلحات موضوعية: *STEM cell transplantation, *COHORT analysis, *PULMONARY aspergillosis, *ASPERGILLOSIS, *MIXED infections, *C-reactive protein, *TRACHEA intubation, *DIAGNOSIS

مستخلص: To describe the coinfections in invasive aspergillosis (IA), to identify factors associated with coinfections, and to evaluate the impact of coinfection on mortality. We conducted a monocentric retrospective study of consecutive putative, probable, or proven IA that occurred between 1997 and 2017. All coinfections, with an onset within 7 days before or after the first sign of aspergillosis, were identified. Factors associated with coinfections and mortality were analysed by multivariable analysis. Among the 690 patients with IA included in the study, the median age was 57 years (range 7 days to 90 years). A coinfection was diagnosed in 272/690 patients (39.4%, 95%CI 35.8–43.2). The location of this coinfection was pulmonary only in 131/272 patients (48%), bloodstream only in 66/272 patients (24%) and other/multiple sites in 75/272 patients (28%). Coinfections were bacterial (110/272 patients, 40%), viral (58/272, 21%), fungal (57/272, 21%), parasitic (5/272, 2%) or due to multiple types of pathogens (42/272, 15%). Factors associated with a coinfection in adjusted analysis were: allogeneic haematopoietic stem-cell transplantation (OR 2.3 (1.2–4.4)), other haematological malignancies (OR 2.1 (1.2–3.8)), other underlying diseases (OR 4.3 (1.4–13.6)), lymphopenia (OR 1.7 (1.1-2.5)), C-reactive protein >180 mg/L (OR 1.9 (1.2–3.0)), fever (OR 2.4 (1.5–4.1)), tracheal intubation (OR 2.6 (1.5–4.7)), isolation of two or more different Aspergillus species (OR 2.7 (1.1–6.3)), and the presence of non-nodular lesions on chest computed tomography (OR 2.2 (1.3–3.7) and OR 2.2 (1.2–4.0)). Coinfections were independently associated with a higher mortality at week 12 (adjusted HR 1.5 (1.1–1.9), p < 0.01). Coinfections are frequent in IA patients and are associated with higher mortality. [ABSTRACT FROM AUTHOR]

المؤلفون: Solis, Morgane^1,2 (AUTHOR), Gallais, Floriane^1,2 (AUTHOR), Garnier-Kepka, Sabrina³ (AUTHOR), Lefebvre, Nicolas⁴ (AUTHOR), Benotmane, Ilies^1,2,5 (AUTHOR), Ludes, Pierre-Olivier⁶ (AUTHOR), Castelain, Vincent⁷ (AUTHOR), Meziani, Ferhat^7,8 (AUTHOR), Caillard, Sophie^2,5 (AUTHOR), Collange, Olivier⁶ (AUTHOR), Fafi-Kremer, Samira^1,2 (AUTHOR) samira.fafi-kremer@unistra.fr

المصدر: Journal of Clinical Virology. Mar2022, Vol. 148, pN.PAG-N.PAG. 1p.

مصطلحات موضوعية: *SARS-CoV-2, *COVID-19, *DNA, *BIOMARKERS

المؤلفون: Noll, Eric¹ (AUTHOR) eric.noll@chru-strasbourg.fr, Soler, Luc^2,3 (AUTHOR), Ohana, Mickael⁴ (AUTHOR), Ludes, Pierre-Olivier^1,5 (AUTHOR), Pottecher, Julien^1,5 (AUTHOR), Bennett-Guerrero, Elliott⁶ (AUTHOR), Veillon, Francis⁷ (AUTHOR), Goichot, Bernard⁸ (AUTHOR), Schneider, Francis⁹ (AUTHOR), Meyer, Nicolas¹⁰ (AUTHOR), Diemunsch, Pierre^1,5,11 (AUTHOR)

المصدر: Anaesthesia Critical Care & Pain Medicine. Feb2021, Vol. 40 Issue 1, pN.PAG-N.PAG. 1p.

مصطلحات موضوعية: *COVID-19, *TREATMENT effectiveness, *LUNG volume measurements, *COMPUTED tomography, *LUNG volume

مستخلص: Ground-glass opacities are the most frequent radiologic features of COVID-19 patients. We aimed to determine the feasibility of automated lung volume measurements, including ground-glass volumes, on the CT of suspected COVID-19 patients. Our goal was to create an automated and quantitative measure of ground-glass opacities from lung CT images that could be used clinically for diagnosis, triage and research. Single centre, retrospective, observational study. Demographic data, respiratory support treatment (synthetised in the maximal respiratory severity score) and CT-images were collected. Volume of abnormal lung parenchyma was measured with conventional semi-automatic software and with a novel automated algorithm based on voxels X-Ray attenuation. We looked for the relationship between the automated and semi-automated evaluations. The association between the ground-glass opacities volume and the maximal respiratory severity score was assessed. Thirty-seven patients were included in the main outcome analysis. The mean duration of automated and semi-automated volume measurement process were 15 (2) and 93 (41) min, respectively (p = 8.05*10−8). The intraclass correlation coefficient between the semi-automated and automated measurement of ground-glass opacities and restricted normally aerated lung were both superior to 0.99. The association between the automated measured lung volume and the maximal clinical severity score was statistically significant for the restricted normally aerated (p = 0.0097, effect-size: −385 mL) volumes and for the ratio of ground-glass opacities/restricted normally aerated volumes (p = 0.027, effect-size: 3.3). The feasibility and preliminary validity of automated impaired lung volume measurements in a high-density COVID-19 cluster was confirmed by our results. [ABSTRACT FROM AUTHOR]