Radical changes in multiple sclerosis pathogenesis
| العنوان: | Radical changes in multiple sclerosis pathogenesis |
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| المؤلفون: | Jack van Horssen, Maarten E. Witte, Helga E. de Vries, Gerty Schreibelt |
| المساهمون: | Molecular cell biology and Immunology, NCA - Multiple Sclerosis and Other Neuroinflammatory Diseases |
| المصدر: | Biochimica et Biophysica Acta. Molecular Basis of Disease, 1812, 141-50 Biochimica et Biophysica Acta. Molecular Basis of Disease, 1812(2), 141-150. Elsevier Biochimica et Biophysica Acta. Molecular Basis of Disease, 1812, 2, pp. 141-50 van Horssen, J, Witte, M E, Schreibelt, G & de Vries, H E 2011, ' Radical changes in multiple sclerosis pathogenesis ', Biochimica et Biophysica Acta. Molecular Basis of Disease, vol. 1812, no. 2, pp. 141-150 . https://doi.org/10.1016/j.bbadis.2010.06.011Test |
| بيانات النشر: | Elsevier B.V. |
| مصطلحات موضوعية: | Encephalomyelitis, Autoimmune, Experimental, Antioxidant, Free Radicals, NF-E2-Related Factor 2, medicine.medical_treatment, Models, Biological, Antioxidants, Lesion, Pathogenesis, Multiple sclerosis, Neuroinflammation, Immune Regulation [NCMLS 2], Oxidative damage, medicine, Animals, Humans, Neurodegeneration, Molecular Biology, chemistry.chemical_classification, Reactive oxygen species, Mechanism (biology), Chemistry, Macrophages, medicine.disease, Mitochondria, Oxidative Stress, Immunology, Cancer research, Molecular Medicine, Microglia, medicine.symptom |
| الوصف: | Item does not contain fulltext Reactive oxygen species (ROS) contain one or more unpaired electrons and are formed as intermediates in a variety of normal biochemical reactions. However, when generated in excess amounts or not appropriately controlled, ROS initiate extensive cellular damage and tissue injury. ROS have been implicated in the progression of cancer, cardiovascular disease and neurodegenerative and neuroinflammatory disorders, such as multiple sclerosis (MS). In the last decade there has been a major interest in the involvement of ROS in MS pathogenesis and evidence is emerging that free radicals play a key role in various processes underlying MS pathology. To counteract ROS-mediated damage, the central nervous system is equipped with an intrinsic defense mechanism consisting of endogenous antioxidant enzymes. Here, we provide a comprehensive overview on the (sub)cellular origin of ROS during neuroinflammation as well as the detrimental effects of ROS in processing underlying MS lesion development and persistence. In addition, we will discuss clinical and experimental studies highlighting the therapeutic potential of antioxidant protection in the pathogenesis of MS. 01 februari 2011 |
| اللغة: | English |
| تدمد: | 0925-4439 |
| DOI: | 10.1016/j.bbadis.2010.06.011 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08450ecd867ac6300d37fa0dd22a4450Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....08450ecd867ac6300d37fa0dd22a4450 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09254439 |
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| DOI: | 10.1016/j.bbadis.2010.06.011 |