التفاصيل البيبلوغرافية
| العنوان: |
Effect of infant formula supplemented with prebiotics and probiotics on incidence of respiratory tract infections: A systematic review and meta-analysis of randomized clinical trials. |
| المؤلفون: |
Rashidi, Kamil, Darand, Mina, Garousi, Nazila, Dehghani, Azadeh, Alizadeh, Shahab |
| المصدر: |
Complementary Therapies in Medicine; Dec2021, Vol. 63, pN.PAG-N.PAG, 1p |
| مستخلص: |
Background: Previous investigations have proposed that the consumption of infant formula supplemented with prebiotics, probiotics and synbiotics (PRO-formula) may have protective impacts on respiratory tract infections (RTIs). Nevertheless, the findings of studies are contradictory. This meta-analysis aimed to explore the influence of PRO-formula on RTIs in infants by pooling randomized controlled trials (RCTs).Methods: To obtain eligible RCTs, Scopus and PubMed databases were systematically searched from their inception to November 2020. A random-effects model was applied to pool the relative risks (RR) and corresponding 95% confidence intervals (CI) for RTIs following consumption of PRO-formula.Results: A total of 15 RCTs, with a total sample size of 3805 participants (1957 for intervention and 1848 for placebo), were included in the present meta-analysis. In the overall analysis, in comparison to placebo, consumption of PRO-formula had a significant protective impact against RTIs (RR = 0.89, 95%CI: 0.82-0.97) in infants, with a remarkable evidence of heterogeneity across studies (I2 = 61.4%, P < 0.001). In the meta-regression analysis, the effect of PRO-formula on RTIs was not modified by the follow-up duration. No evidence for publication bias was detected.Conclusions: Administration of PRO-formula may be a potential approach for the prevention of respiratory tract infections in infants. [ABSTRACT FROM AUTHOR] |
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