المؤلفون: Markoula, Sofia, Chaudhary, Umair J., Perani, Suejen, De Ciantis, Alessio, Yadee, Tinonkorn, Duncan, John S., Diehl, Beate, McEvoy, Andrew W., Lemieux, Louis

المصدر: Seizure; Oct2018, Vol. 61, p30-37, 8p

مستخلص: Purpose: We set out to establish the clinical utility of EEG-correlated fMRI as part of the presurgical evaluation, by measuring prospectively its effects on the clinical decision.Methods: Patients with refractory extra-temporal focal epilepsy, referred for presurgical evaluation were recruited in a period of 18 months. The EEG-fMRI based localization was presented during a multi-disciplinary meeting after the team had defined the presumed RESULTS: Sixteen patients (six women), with a median age of 28 years, were recruited. Interpretable EEG-fMRI results were available in 13: interictal epileptic discharges (IEDs) were recorded in eleven patients and seizures were recorded in two patients. In three patients, no epileptic activity was captured during EEG-fMRI acquisition and in two of those an IED topographic map correlation was performed (between EEG recorded inside the scanner and long-term video EEG monitoring). EEG-fMRI results presentation had no impact on the initial clinical decision in three patients (23%) of the thirteen and resulted in a modification of the initial surgical plan in ten patients (77%) of the thirteen finally presented in MDT; in eight patients the impact was on the planned placement of invasive electrodes and in two patients the EEG-fMRI led to additional non-invasive tests before proceeding further with surgery.Conclusion: The study is a prospective observational cohort study specifically designed to assess the impact of EEG-fMRI on the clinical decision making process, suggesting a significant influence of EEG-fMRI on epilepsy surgery planning. [ABSTRACT FROM AUTHOR]

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المؤلفون: Chaudhary, Umair J.^1,2, Kokkinos, Vasileios^1,2, Carmichael, David W.^1,2, Rodionov, Roman^1,2, Gasston, David³, Duncan, John S.^1,2,4, Lemieux, Louis^1,2 l.lemieux@ion.ucl.ac.uk

المصدر: Magnetic Resonance Imaging (0730725X). Oct2010, Vol. 28 Issue 8, p1192-1199. 8p.

مصطلحات موضوعية: *ELECTROENCEPHALOGRAPHY, *MAGNETIC resonance imaging of the brain, *BRAIN mapping, *BLOOD circulation, *NEUROLOGICAL disorders, *LINEAR statistical models, *BRAIN function localization

مستخلص: Abstract: The objective of this study was to demonstrate that the addition of simultaneous and synchronised video to electroencephalography (EEG)-correlated functional magnetic resonance imaging (fMRI) could increase recorded information without data quality reduction. We investigated the effect of placing EEG, video equipment and their required power supplies inside the scanner room, on EEG, video and MRI data quality, and evaluated video-EEG-fMRI by modelling a hand motor task. Gradient-echo, echo-planner images (EPI) were acquired on a 3-T MRI scanner at variable camera positions in a test object [with and without radiofrequency (RF) excitation], and human subjects. EEG was recorded using a commercial MR-compatible 64-channel cap and amplifiers. Video recording was performed using a two-camera custom-made system with EEG synchronization. An in-house script was used to calculate signal to fluctuation noise ratio (SFNR) from EPI in test object with variable camera positions and in human subjects with and without concurrent video recording. Five subjects were investigated with video-EEG-fMRI while performing hand motor task. The fMRI time series data was analysed using statistical parametric mapping, by building block design general linear models which were paradigm prescribed and video based. Introduction of the cameras did not alter the SFNR significantly, nor did it show any signs of spike noise during RF off conditions. Video and EEG quality also did not show any significant artefact. The Statistical Parametric Mapping{T} maps from video based design revealed additional blood oxygen level-dependent responses in the expected locations for non-compliant subjects compared to the paradigm prescribed design. We conclude that video-EEG-fMRI set up can be implemented without affecting the data quality significantly and may provide valuable information on behaviour to enhance the analysis of fMRI data. [Copyright &y& Elsevier]

المؤلفون: Sharma, Niraj K.¹ niraj.sharma.14@ucl.ac.uk, Pedreira, Carlos², Centeno, Maria¹, Chaudhary, Umair J.¹, Wehner, Tim¹, França, Lucas G.S.¹, Yadee, Tinonkorn¹, Murta, Teresa¹, Leite, Marco¹, Vos, Sjoerd B.^1,3, Ourselin, Sebastien^1,3,4, Diehl, Beate¹, Lemieux, Louis¹

المصدر: Clinical Neurophysiology. Jul2017, Vol. 128 Issue 7, p1246-1254. 9p.

مصطلحات موضوعية: *EPILEPSY, *SOCIAL segmentation, *PEOPLE with epilepsy, *CHRONICALLY ill, *INFORMATION science

مستخلص: Objective To validate the application of an automated neuronal spike classification algorithm, Wave_clus (WC), on interictal epileptiform discharges (IED) obtained from human intracranial EEG (icEEG) data. Method Five 10-min segments of icEEG recorded in 5 patients were used. WC and three expert EEG reviewers independently classified one hundred IED events into IED classes or non-IEDs. First, we determined whether WC-human agreement variability falls within inter-reviewer agreement variability by calculating the variation of information for each classifier pair and quantifying the overlap between all WC-reviewer and all reviewer-reviewer pairs. Second, we compared WC and EEG reviewers’ spike identification and individual spike class labels visually and quantitatively. Results The overlap between all WC-human pairs and all human pairs was >80% for 3/5 patients and >58% for the other 2 patients demonstrating WC falling within inter-human variation. The average sensitivity of spike marking for WC was 91% and >87% for all three EEG reviewers. Finally, there was a strong visual and quantitative similarity between WC and EEG reviewers. Conclusions WC performance is indistinguishable to that of EEG reviewers’ suggesting it could be a valid clinical tool for the assessment of IEDs. Significance WC can be used to provide quantitative analysis of epileptic spikes. [ABSTRACT FROM AUTHOR]