دورية أكاديمية
CSF omeprazole concentration and albumin quotient following high dose intravenous omeprazole in dogs.
| العنوان: | CSF omeprazole concentration and albumin quotient following high dose intravenous omeprazole in dogs. |
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| المؤلفون: | Girod, M, Allerton, F, Vangrinsven, Emilie, Tutunaru, Alexandru-Cosmin, de Marchin, J, Gomez Fernandez Blanco, Carlos, Ruiz-Nuño, A, Wojnicz, A, Farnir, Frédéric, Gommeren, Kris, Peeters, Dominique |
| المصدر: | Research in Veterinary Science, 125, 266-271 (2019-08) |
| بيانات النشر: | Elsevier B.V., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Acetazolamide, Albumin quotient, Cerebrospinal fluid production, Furosemide, Omeprazole, Anti-Ulcer Agents, Biomarkers, Serum Albumin, Administration, Intravenous, Animals, Anti-Ulcer Agents/administration & dosage, Anti-Ulcer Agents/cerebrospinal fluid, Anti-Ulcer Agents/pharmacokinetics, Biomarkers/blood, Cross-Over Studies, Dose-Response Relationship, Drug, Female, Male, Omeprazole/administration & dosage, Omeprazole/cerebrospinal fluid, Omeprazole/pharmacokinetics, Prospective Studies, Random Allocation, Dogs, Veterinary (all), General Veterinary, Life sciences, Veterinary medicine & animal health, Sciences du vivant, Médecine vétérinaire & santé animale |
| الوصف: | Clinical signs of syringomyelia and hydrocephalus occur secondary to cerebrospinal fluid (CSF) accumulation within the central nervous system. Omeprazole is recommended to treat these conditions despite little evidence of its capacity to decrease CSF production in the dog. Studies into new treatments are hampered by difficulties in measuring CSF production. The albumin quotient (QAlb), the ratio between CSF and serum albumin concentrations, may reflect CSF production and any decrease in CSF production should be associated with an increase in QAlb. The primary objective of this study was to determine CSF omeprazole concentration after administration of a high intravenous dose of omeprazole and to evaluate its impact on QAlb in the dog. The second aim was to validate QAlb as a surrogate marker of CSF production. Eighteen dogs were included in this prospective crossover placebo-controlled study. Each dog received omeprazole (10 mg/kg), acetazolamide (50 mg/kg) combined with furosemide (1 mg/kg) and saline. Blood and CSF samples were obtained on day 0 and then every 7 days, one hour after drug administration. Omeprazole concentrations (2.0 ± 0.4 μmol/L) reached in CSF after high dose omeprazole were lower than the concentrations previously described as decreasing CSF production in dogs. There was no significant increase in QAlb following administration of acetazolamide/furosemide, prohibiting validation of QAlb as a surrogate marker for CSF production. Several dogs presented transient mild side effects after injection of acetazolamide/furosemide. High dose omeprazole was well tolerated in all dogs. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | https://api.elsevier.com/content/article/PII:S003452881831662X?httpAccept=text/xmlTest; 10.1016/j.rvsc.2019.07.009; urn:issn:0034-5288; urn:issn:1532-2661 |
| DOI: | 10.1016/j.rvsc.2019.07.009 |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/297005Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.297005 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1016/j.rvsc.2019.07.009 |
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