Innovative electrochemical sensor for the precise determination of the new antiviral COVID-19 treatment Favipiravir in the presence of coadministered drugs
| العنوان: | Innovative electrochemical sensor for the precise determination of the new antiviral COVID-19 treatment Favipiravir in the presence of coadministered drugs |
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| المؤلفون: | Ghada M. G. Eldin, Nadia Zine, Sani M. Ismail, Abdelhamid Errachid, Nicole Jaffrezic-Renault, Abdelhamid Elaissari, Mona A. Mohamed |
| المساهمون: | National Organization for Drug Control and Research - Pharmaceutical Chemistry Department, Micro & Nanobiotechnologies, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), The authors acknowledge the partial funding from KardiaTool, H2020, under the grant number 768686 and POC Allergies through the ERA PerMed program. Mona A. Mohamed thanks the French Embassy in Egypt for supporting this work. Campus France is acknowledged for financial support through PHC Imhotep # 46354WG. |
| المصدر: | Journal of Electroanalytical Chemistry (Lausanne, Switzerland) Journal of Electroanalytical Chemistry Journal of Electroanalytical Chemistry, Elsevier 2021, 895, pp.115422. ⟨10.1016/j.jelechem.2021.115422⟩ |
| بيانات النشر: | Elsevier B.V., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), General Chemical Engineering, 02 engineering and technology, Favipiravir, 010402 general chemistry, 01 natural sciences, World health, Dosage form, Article, Analytical Chemistry, Electrochemistry, [CHIM]Chemical Sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, corona virus, ComputingMethodologies_COMPUTERGRAPHICS, Real sample analysis, Detection limit, Chromatography, Chemistry, COVID-19, 021001 nanoscience & nanotechnology, 3. Good health, 0104 chemical sciences, Electrochemical gas sensor, Linear range, Graphene derivatives, 0210 nano-technology, COVID 19 |
| الوصف: | Graphical abstract Due the current pandemic of COVID-19, an urgent need is required for serious medical treatments of a huge number of patients. The world health organization (WHO) approved Favipiravir (FAV) as a medication for patients infected with corona virus. In the current study, we report the first simple electrochemical, greatly sensitive sensor using MnO2-rGO nanocomposite for the accurate determination of Favipiravir (FAV). The developed sensor showed a high improvement in the electrochemical oxidation of FAV comparing to the unmodified screen-printed electrode (SPE). The suggested platform constituents and the electrochemical measurements parameters were studied. Under optimal experimental parameters, a current response to the concentration change of FAV was found to be in the linear range of 1.0 × 10−8–5.5 × 10−5 M at pH 7.0 with a limit of detection 0.11 µM and a quantification limit of 0.33 µM. The developed platform was confirmed by the precise analysis of FAV in real samples including dosage form and plasma. The developed platform can be applied in different fields of industry quality control and clinical analysis laboratories for the FAV determination. |
| اللغة: | English |
| تدمد: | 1873-2569 1572-6657 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed1f855643dcb952f1436479c357a07Test http://europepmc.org/articles/PMC8161794Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8ed1f855643dcb952f1436479c357a07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18732569 15726657 |
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