التفاصيل البيبلوغرافية
| العنوان: |
Comparison of the Effect of Rosuvastatin 2.5 mg vs 20 mg on Coronary Plaque Determined by Angioscopy and Intravascular Ultrasound in Japanese With Stable Angina Pectoris (from the Aggressive Lipid-Lowering Treatment Approach Using Intensive Rosuvastatin for Vulnerable Coronary Artery Plaque [ALTAIR] Randomized Trial). |
| المؤلفون: |
Takayama, Tadateru1 (AUTHOR), Komatsu, Sei2 (AUTHOR), Ueda, Yasunori3 (AUTHOR), Fukushima, Seiji1 (AUTHOR), Hiro, Takafumi1 (AUTHOR), Hirayama, Atsushi1 (AUTHOR), Saito, Satoshi4 (AUTHOR), ALTAIR study group (CORPORATE AUTHOR) |
| المصدر: |
American Journal of Cardiology. 4/15/2016, Vol. 117 Issue 8, p1206-1212. 7p. |
| مصطلحات موضوعية: |
*DRUG therapy for angina pectoris, *ATHEROSCLEROSIS complications, *ANGINA pectoris, *ANGIOSCOPY, *ANTILIPEMIC agents, *ATHEROSCLEROSIS, *COMPARATIVE studies, *CORONARY arteries, *DOSE-effect relationship in pharmacology, *LIPIDS, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *ULTRASONIC imaging, *EVALUATION research, *RANDOMIZED controlled trials, *TREATMENT effectiveness, *DISEASE incidence, *BLIND experiment, *DIAGNOSIS |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
Diminishing yellow color, evaluated by coronary angioscopy, is associated with plaque stabilization and regression. Our aim was to assess the effect of aggressive lipid-lowering therapy with rosuvastatin on plaque regression and instability. Thirty-seven patients with stable angina or silent myocardial ischemia who planned to undergo elective percutaneous coronary intervention and had angioscopic yellow plaques of grade 2 or more were randomized to high-dose (group H, 20 mg/day, n = 18) or low-dose (group L, 2.5 mg/day, n = 19) rosuvastatin therapy for 48 weeks. Yellow plaque was graded on a 4-point scale of 0 (white) to 3 (bright yellow) by angioscopy, and plaque volume was determined by intravascular ultrasound for plaques with a length of 5 to 15 mm. Color and volume were assessed at baseline and after 48 weeks by the investigators blinded to the rosuvastatin dosage, and were compared between the 2 dosing groups. The level of low-density lipoprotein-cholesterol decreased from 130.3 ± 25.5 mg/dl to 61.7 ± 16.5 mg/dl (-50 ± 19%: high intensity) in group H (p <0.001) and from 130.9 ± 28.5 mg/dl to 89.7 ± 29.0 mg/dl (-30 ± 22%: moderate intensity) in group L (mean ± SD, p <0.001). The average color grade of yellow plaques decreased from 2.0 to 1.5 in group H (p <0.001) and from 2.0 to 1.6 in group L (p <0.001) after 48 weeks. Plaque volume decreased significantly in group H but not in group L. The percent change in plaque volume was significantly larger in group H than in group L (p = 0.005). In conclusion, both high-dose and low-dose rosuvastatin increased plaque stability. However, high-dose rosuvastatin was more effective than low-dose rosuvastatin in inducing plaque volume regression. Clinical Trial Registration No: UMIN-CTR, UMIN000003276. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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