Predicting hemorrhagic transformation in patients not submitted to reperfusion therapies
| العنوان: | Predicting hemorrhagic transformation in patients not submitted to reperfusion therapies |
|---|---|
| المؤلفون: | Joao José de Freitas Carvalho, Gabriel Pinheiro Modolo, Fabricio O. Lima, Matheus Mendes Pires, Rodrigo Bazan, Luisa Franciscato, João Brainer Clares de Andrade, Octavio M. Pontes-Neto, Kristel Larisa Back Merida, Renata Carolina Acri Nunes Miranda, Jamary Oliveira-Filho, Gisele Sampaio Silva, Jay P. Mohr, Mayara Silva Marques, Victor A. E. de Farias |
| المساهمون: | Universidade Federal de São Paulo (UNIFESP), Columbia Univ, Univ Fortaleza, Hosp Geral Fortaleza, Univ Fed Ceara, Universidade Federal da Bahia (UFBA), Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp), Hosp Inst Neurol Curitiba, Hosp Israelita Brasileiro Albert Einstein |
| المصدر: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| بيانات النشر: | Elsevier B.V., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Logistic regression, Risk Assessment, Asymptomatic, Brain Ischemia, Decision Support Techniques, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, Humans, Medicine, Prospective Studies, Derivation, Grading (tumors), Stroke, Aged, Retrospective Studies, Aged, 80 and over, Ischemic stroke, Receiver operating characteristic, business.industry, Hemorrhagic transformation, Incidence, Rehabilitation, Leukoaraiosis, Reproducibility of Results, ComplicationVascular neurology, Middle Aged, Prognosis, medicine.disease, Female, Surgery, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, Complication, Intracranial Hemorrhages, Brazil, 030217 neurology & neurosurgery |
| الوصف: | Made available in DSpace on 2020-12-12T00:07:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Background: Well studied in patients with ischemic stroke after reperfusion thera-pies (RT), hemorrhagic transformation (HT) is also common in patients not treated with RT and can lead to disability even in initially asymptomatic cases. The best predictors of HT in patients not treated with RT are not well established. Therefore, we aimed to identify predictors of HT in patients not submitted to RT and create a user-friendly predictive score (PROpHET). Material and Methods: Patients admitted to a Comprehensive Stroke Center from 2015 to 2017 were prospectively evaluated and randomly selected to the derivation cohort. A multivariable logistic regression modeling was built to produce a predictive grading score for HT. The external vali-dation was assessed using datasets from 7 Comprehensive Stroke Centers using the area under the receiver operating characteristic curve (AUROC). Results: In the derivation group, 448 patients were included in the final analysis. The validation group included 2,683 patients. The score derived from significant predictors of HT in the multivariate logistic regression analysis was male sex (1 point), ASPECTS = 180 mg/dL (1 point), cardioembolism (1 point) and lacunar syndrome (-3 points) as a protective factor. The grading score ranges from -3 to 7. A Score >= 3 had 78.2% sensitivity and 75% specificity, and AUROC of 0.82 for all cases of HT. In the validation cohort, our score had an AUROC of 0.83. Conclusions: The PROpHET is a simple, quick, cost-free, and easy-to-perform tool that allows risk stratification of HT in patients not submitted to RT. A cost-free computerized version of our score is available online with a user-friendly interface. Univ Fed Sao Paulo, Rua Napoleao Barros 715, Sao Paulo, SP, Brazil Columbia Univ, Doris & Stanley Tananbaum Stroke Ctr, Neurol Inst New York, 710 W 168th St,6TH Floor,NI 614, New York, NY 10032 USA Univ Fortaleza, Fortaleza, Cear, Brazil Hosp Geral Fortaleza, Fortaleza, Ceara, Brazil Univ Fed Ceara, Campus Quixada, Quixada, CE, Brazil Univ Fed Bahia, Salvador, BA, Brazil Univ Sao Paulo, Ribeirao Preto, Brazil Univ Estadual Paulista, Sao Paulo, Brazil Hosp Inst Neurol Curitiba, Curitiba, Parana, Brazil Hosp Geral Fortaleza, Rua Avila Goulart 900, Fortaleza, CE, Brazil Praca 15 Novembro SN, Salvador, BA, Brazil Hosp Clin, Floor 4th, Ribeirao Preto, SP, Brazil Av Prof Mario Rubens Guimaraes Montenegro, Botucatu, SP, Brazil R Jeremias Maciel Perretto 300, Curitiba, PR, Brazil Hosp Israelita Brasileiro Albert Einstein, Rua Albert Einstein 627, Sao Paulo, SP, Brazil Univ Estadual Paulista, Sao Paulo, Brazil |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e25494e3b275dcf3ea4fd12c024468Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....15e25494e3b275dcf3ea4fd12c024468 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |