المؤلفون: Cui, Zhaolei¹ (AUTHOR), Chen, Yansong¹ (AUTHOR), Hu, Minhua¹ (AUTHOR), Lin, Yingfeng¹ (AUTHOR), Zhang, Shuyu¹ (AUTHOR), Kong, Lingying^1,2 (AUTHOR) lingyingkong2014@163.com, Chen, Yan¹ (AUTHOR) yanc2015@163.com

المصدر: Clinica Chimica Acta. Apr2020, Vol. 503, p203-209. 7p.

مصطلحات موضوعية: *LACTATE dehydrogenase, *BREAST cancer, *ANTIGENS, *TISSUE analysis, *PROTEIN expression

مستخلص: • LDHC mRNA and protein are up-regulated in BC. • Serum or exosomal LDHC is a powerful indicator in the management of patients with BC. • LDH-C4 serves as a promising prognostic biomarker for BC. Lactate dehydrogenase C4 (LDH-C4) as a cancer/testis antigen (CTA) is abnormally expressed in some malignant tumors. However, the expression and clinical significance of LDH-C4 in breast cancer (BC) has not been characterized. We determined LDHC mRNA expression in serum and serum-derived exosomes of BC patients by quantitative RT-PCR. We also evaluated the protein expression of LDH-C4 in BC tissues using high-throughput tissue microarray analysis and immunohistochemistry. Our results showed high mRNA expression level of LDHC in serum and serum-derived exosomes of BC patients. The LDHC level in serum and exosomes could distinguish BC cases from healthy individuals based on their AUCs of 0.9587 and 0.9464, respectively. Besides, the LDHC level in exosomes of BC patients associated with tumor size, and positively correlated with HER2 and Ki-67 expressions (all with P < 0.05). Serum and exosomal level of LDHC negatively correlated with medical treatment and positively with the recurrence of BC. Survival analysis showed that LDH-C4 expression negatively correlated with BC prognosis. Serum and exosomal LDHC may be an effective indicator for the diagnosis, efficacy evaluation, and monitoring the recurrence of BC. LDH-C4 may act as a biomarker that predicts BC prognosis. [ABSTRACT FROM AUTHOR]

المؤلفون: Lee, Doh Young¹ (AUTHOR), Kang, Karam² (AUTHOR), Jung, Hwaejoon² (AUTHOR), Park, Young Min² (AUTHOR), Cho, Jae-Gu² (AUTHOR), Baek, Seung-Kuk² (AUTHOR), Kwon, Soon-Young² (AUTHOR), Jung, Kwang-Yoon² (AUTHOR), Woo, Jeong-Soo^1,2 (AUTHOR) diakonos@korea.ac.kr

المصدر: Auris Nasus Larynx. Feb2019, Vol. 46 Issue 1, p114-121. 8p.

مصطلحات موضوعية: *DIFFUSE large B-cell lymphomas, *LACTATE dehydrogenase, *TONSILS, *NECK, *LYMPHOMAS, *PROGNOSIS, *PROTEIN metabolism, *B cell lymphoma, *CAUSES of death, *HEAD tumors, *LYMPH nodes, *NECK tumors, *PROTEOLYTIC enzymes, *TONGUE, *TUMOR classification, *RETROSPECTIVE studies, NASOPHARYNX tumors, PHARYNX tumors

مستخلص: Objective: In this study, we analyzed clinicopathological characteristics and survival outcomes according to extranodal involvement of diffuse large B-cell lymphoma (DLBCL) in the head and neck.Methods: A retrospective analysis was conducted on 110 patients from 2004 to 2014 with CD20-positive DLBCL involving the head and neck area. Patients were categorized into two groups, extranodal and nodal, according to involvement of extranodal sites in the head and neck. Outcome measurements for the groups included clinical response to treatment and recurrence rates.Results: Palatine tonsils were the most frequently involved extranodal site in the head and neck (29.1%). Among clinicopathological parameters, proportion of patients with lactate dehydrogenase over 350 IU/L (p=0.033), cell of origin (p<0.001), and treatment outcomes (p=0.007) were significantly different between the two groups. Among cell origin markers CD10, Bcl6, and MUM1, MUM1 was significantly correlated with extranodal involvement (p=0.029). Recurrence rates were similar between groups, while disease-specific survival was significantly higher in the extranodal group (p=0.011). Disease-specific survival of the extranodal group was also higher than the nodal group with extranodal involvement of other body sites (p=0.010). Among patients with negative expression of CD10 (p=0.015), Bcl6 (p=0.018), and MUM1 (p=0.005), survival was longer in the extranodal than the nodal group.Conclusions: DLBCL patients with extranodal involvement of the head and neck may have longer survival outcomes than patients with solely nodal involvement. Increased survival may be more prominent in patients with negative expression of CD10, Bcl6, and MUM1. [ABSTRACT FROM AUTHOR]

المؤلفون: Fernando, Shannon M.^1,2, Barnaby, Douglas P.³, Herry, Christophe L.⁴, Gallagher, E. John³, Shapiro, Nathan I.⁵, Seely, Andrew J.e.^2,4,6

المصدر: Journal of Emergency Medicine (0736-4679). Jun2018, Vol. 54 Issue 6, p766-773. 8p.

مصطلحات موضوعية: *SEPSIS, *LACTATE dehydrogenase, *NONINVASIVE diagnostic tests, *LIKELIHOOD ratio tests, *PROGNOSIS, *DISEASE risk factors

مستخلص: Background: Early emergency department (ED) identification of septic patients at risk of deterioration is critical. Lactate is associated with 28-day mortality in admitted patients, but little evidence exists on its use in predicting short-term deterioration.Objective: Our aim was to determine the role of initial serum lactate for prediction of short-term deterioration in stable ED patients with suspected sepsis.Methods: We conducted a prospective cohort study of adult ED sepsis patients. Venous lactate was obtained within 2 h of ED arrival. Main outcome was subsequent deterioration (defined as any of the following: death, intensive care admission > 24 h, intubation, vasoactive medications for > 1 h, or noninvasive positive pressure ventilation for > 1 h) within 72 h. Patients meeting any endpoint within 1 h of arrival were excluded.Results: Nine hundred and eighty-five patients were enrolled, of whom 84 (8.5%) met the primary outcome of deterioration. Initial lactate ≥ 4.0 mmol/L had a specificity of 97% (95% confidence interval [CI] 94-100%), but a sensitivity of 27% (95% CI 18-37%) for predicting deterioration, with positive and negative likelihood ratios of 10.7 (95% CI 6.3-18.3) and 0.8 (95% CI 0.7-0.9), respectively. A lower threshold of lactate (≥2.0 mmol/L) had a sensitivity of 67% (95% CI 55-76%) and specificity of 66% (95% CI 63-69%), with corresponding positive and negative likelihood ratios of 2.0 (95% CI 1.7-2.3) and 0.5 (95% CI 0.4-0.7).Conclusions: High ED lactate is predictive of subsequent deterioration from sepsis within 72 h, and may be useful in determining disposition, but low lactate is not effective in screening stable patients at risk of deterioration. [ABSTRACT FROM AUTHOR]

المؤلفون: Koh, Young Wha¹, Lee, Su Jin², Park, Seong Yong³

المصدر: Pathology - Research & Practice. Sep2017, Vol. 213 Issue 9, p1134-1138. 5p.

مصطلحات موضوعية: *LACTATE dehydrogenase, *NON-small-cell lung carcinoma, *HISTOLOGY, *BLOOD serum analysis, *SQUAMOUS cell carcinoma, *GENE expression, *PROGNOSIS

مستخلص: Lactate dehydrogenase B (LDHB) expression and the level of serum LDH were involved in tumor progression. Correlations between these parameters and their prognostic significance were not assessed in non-small cell lung cancer (NSCLC). We evaluated LDHB expression by immunohistochemical method and serum LDH in 243 NSCLC patients treated with surgical resection [136 adenocarcinomas (ADCs), 89 squamous cell carcinomas (SqCCs) and 18 other type carcinomas]. Correlation between LDHB expression and serum LDH was assessed, and the prognostic significance was determined. LDHB expression was identified in 52% of SqCC and 55% of ADC tissue samples. LDHB-positive SqCC patients had a higher recurrence-free survival (RFS) rate than LDHB-negative patients ( p = 0.017). LDHB-positive and LDHB-negative patients showed similar RFS rates in ADCs ( p = 0.519). Multivariate analysis showed that LDHB expression was an independent risk factor in lung SqCCs (hazard ratio = 0.393, p = 0.028). A positive correlation was found between LDHB expression and serum LDH level ( p = 0.02). High LDHB expression is significantly associated with the level of serum LDH and better clinical outcomes in lung SqCC. [ABSTRACT FROM AUTHOR]

المؤلفون: Stankovic Stojanovic, Katia¹ katia.stankovic@tnn.aphp.fr, Lionnet, François¹

المصدر: Clinica Chimica Acta. Jul2016, Vol. 458, p99-102. 4p.

مصطلحات موضوعية: *SICKLE cell anemia, *LACTATE dehydrogenase, *PATHOLOGICAL physiology, *HEMOLYSIS & hemolysins, *BLOOD platelet activation, *VASOCONSTRICTION

مستخلص: Lactate dehydrogenase (LDH) activity is elevated in many pathological states. Interest in LDH activity in sickle cell disease (SCD) has developed out of an increased comprehension of the pathophysiological process and the clinical course of the disease. Elevated LDH activity in SCD comes from various mechanisms, especially intravascular hemolysis, as well as ischemia-reperfusion damage and tissular necrosis. Intravascular hemolysis is associated with vasoconstriction, platelet activation, endothelial damage, and vascular complications. LDH has been used as a diagnostic and prognostic factor of acute and chronic complications. In this review we have evaluated the literature where LDH activity was examined during steady-state or acute conditions in SCD. [ABSTRACT FROM AUTHOR]

المؤلفون: Stankovic Stojanovic, Katia¹ katia.stankovic@tnn.aphp.fr, Steichen, Olivier^1,2, Lefevre, Guillaume³, Bachmeyer, Claude¹, Avellino, Virginie¹, Grateau, Gilles^1,2, Girot, Robert^2,4, Lionnet, François¹

المصدر: Clinical Biochemistry. Dec2012, Vol. 45 Issue 18, p1578-1582. 5p.

مصطلحات موضوعية: *LACTATE dehydrogenase, *SICKLE cell anemia, *LEUCOCYTES, *DEHYDROGENASES, *CALCITONIN, *ARTERIAL occlusions

مستخلص: Abstract: Objectives: The aim of this study is to assess biological prognostic factors at the onset of vaso-occlusive crisis (VOC) in adults with sickle cell disease (SCD). Methods: A monocentric prospective study including all patients admitted for VOC in a reference center for SCD was utilized. We used multivariate logistic regression to find independent predictors of severe evolution, defined by death or a worsening clinical state indicating transfusion or transfer to the intensive care unit. Results: Eighty eight patients were included, 63% were women, median age of 23years, and 90% of patients were homozygous SCD, 10% compound heterozygous. VOC became severe in 17 patients. Patients with severe VOC were more frequently males, who also had higher white blood cell (WBC) count, procalcitonin (PCT), and lactate dehydrogenase (LDH) levels. LDH level was the best predictor of the outcome; WBC and PCT had no significant added predictive values when coupled with LDH in multivariable models, even in patients with fever or acute chest syndrome. Severe evolution always occurred when LDH levels were over 4 times the upper limit of the normal range at admission and never occurred when LDH levels were within the normal range. Conclusion: Further studies should confirm the predictive value of LDH before its widespread use as a prognostic factor. If it is confirmed, the benefit of preemptive transfusion when LDH levels at admission are very high could be investigated. [Copyright &y& Elsevier]

المؤلفون: Yi, J. H.¹, Kim, J. H.¹, Baek, K. K.¹, Lim, T.¹, Lee, D. J.¹, Ahn, Y. C.², Kim, K.¹, Kim, S. J.¹, Ko, Y. H.³, Kim, W. S.¹

المصدر: Annals of Oncology. Jul2011, Vol. 22 Issue 7, p1636-1643. 8p. 1 Diagram, 6 Charts, 2 Graphs.

مصطلحات موضوعية: *T-cell lymphoma, *LACTATE dehydrogenase, *PARANASAL sinuses, *CENTRAL nervous system diseases, *CANCER prognosis, *RETROSPECTIVE studies, *HEALTH outcome assessment, *DISEASE risk factors, *THERAPEUTICS

مستخلص: Background: The incidence and risk factors of central nervous system (CNS) involvement in peripheral T-cell lymphomas (PTCLs) are still unclear.Patients and methods: We analyzed 228 patients with PTCLs, excluding cases of extranodal natural killer/T-cell lymphoma and primary cutaneous T-cell lymphoma, by retrospectively collecting the clinical features and outcomes of the patients.Results: Twenty events (8.77%, 20/228) of CNS involvement were observed during a median follow-up period of 13.9 months (range 0.03–159.43). Based on univariate analysis, elevated serum lactate dehydrogenase (LDH) level [P = 0.019, relative risk (RR) 5.904, 95% confidence interval (CI) 1.334–26.123] and involvement of the paranasal sinus (P = 0.032, RR 3.137, 95% CI 1.105–8.908) adversely affect CNS involvement. In multivariate analysis, both were independently poor prognostic factors for CNS relapse [elevated LDH level: P = 0.011, hazard ratio (HR) 6.716, 95% CI 1.548–29.131; involvement of the paranasal sinus: P = 0.008, HR 3.784, 95% CI 1.420–10.083]. The survival duration of patients with CNS involvement was significantly shorter than that of the patients without CNS involvement (P = 0.009), with median overall survival of 7.60 months (95% CI of 4.92–10.28) versus 27.43 months (95% CI of 0.00–57.38), respectively.Conclusions: Elevated LDH level and involvement of the paranasal sinus are two risk factors for CNS involvement in patients with PTCLs. Considering the poor prognoses after CNS relapse, prophylaxis should be considered with the presence of any risk factor. [ABSTRACT FROM AUTHOR]

المؤلفون: Kastritis, Efstathios¹, Kyrtsonis, Marie-Christine¹, Hadjiharissi, Evdoxia¹, Symeonidis, Argyris¹, Michalis, Evridiki¹, Repoussis, Panagiotis¹, Tsatalas, Constantinos¹, Michael, Michael¹, Sioni, Anastasia¹, Kartasis, Zafiris¹, Stefanoudaki, Ekaterini¹, Voulgarelis, Michail¹, Delimpasi, Sossana¹, Gavriatopoulou, Maria¹, Koulieris, Efstathios¹, Gika, Dimitra¹, Zomas, Athanasios¹, Roussou, Paraskevi¹, Anagnostopoulos, Nikolaos¹, Economopoulos, Theophanis¹

المصدر: Leukemia Research. Oct2010, Vol. 34 Issue 10, p1340-1343. 4p.

مصطلحات موضوعية: *LYMPHOMAS, *LACTATE dehydrogenase, *ALKYLATING agents, *LEGG-Calve-Perthes disease, *NUCLEOSIDES, *BLOOD plasma, *RITUXIMAB, *PROGNOSIS

مستخلص: Abstract: The recently proposed, ISSWM staging system for symptomatic patients with WM was based on patients treated with alkylating agents and nucleoside analogs and has not been externally validated nor has been validated for cause-specific survival (CSS). We independently validated ISSWM both for overall survival (OS) and for CSS and assessed whether addition of elevated serum LDH may add to the strength of ISSWM in 335 patients treated upfront mainly with alkylating agents (43%), and rituximab-based therapies (47%). ISSWM could discriminate three groups with significantly different OS and CSS (p <0.01 for both). High serum LDH was predictive of shorter OS and CSS (p <0.01). The combination of high risk according to ISSWM and elevated serum LDH identified a subset of patients for whom innovative treatment approaches are needed. [ABSTRACT FROM AUTHOR]

المؤلفون: Van De Schans, S. A. M.¹ research@ikz.nl, Steyerberg, E. W.², Nijziel, M. R.³, Creemers, G.-J.⁴, Janssen-Heijnen, M. L.¹, Van Spronsen, D. J.⁵

المصدر: Annals of Oncology. Oct2009, Vol. 20 Issue 10, p1697-1702. 6p. 5 Charts.

مصطلحات موضوعية: *LYMPHOMAS, *LACTATE dehydrogenase, *PROGNOSIS

مصطلحات جغرافية: EINDHOVEN (Netherlands), NETHERLANDS

مستخلص: Background: The aim of this study was to validate the Follicular Lymphoma International Prognostic Index (FLIPI) in a population-based cohort and to study the relevance of revision and extension of the FLIPI. [ABSTRACT FROM PUBLISHER]

المؤلفون: Su, Shiqiang¹ (AUTHOR), Liu, Lizhe² (AUTHOR), Sun, Chao¹ (AUTHOR) sunchaoppt@163.com, Yang, Lijun¹ (AUTHOR), Nie, Yanhua¹ (AUTHOR), Chen, Yan¹ (AUTHOR), Zhang, Jin¹ (AUTHOR), Li, Shen¹ (AUTHOR)

المصدر: Urologic Oncology. Nov2020, Vol. 38 Issue 11, p852.e1-852.e9. 1p.

مصطلحات موضوعية: *URINARY diversion, *LACTATE dehydrogenase, *BLADDER cancer, *CYSTECTOMY, *PROPORTIONAL hazards models, *PROGNOSIS, *RETROSPECTIVE studies, *OXIDOREDUCTASES, BLADDER tumors

مستخلص: Background: To investigate the prognostic significance of preoperative serum lactate dehydrogenase (LDH) in patients undergoing radical cystectomy for bladder cancer (BCa).Patients and Methods: A cohort of 263 patients undergoing open or laparoscopic radical cystectomy between 2011 and 2016 was studied. Baseline characteristics, hematological variables, follow-up data were collected. Kaplan-Meier curves and Cox proportional hazard regression model were applied to assess the relationship between LDH and overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS).Results: After a median 34.2 (22.9-45.8) months follow-up, all-cause death, cancer-specific death, and disease recurrence occurred in 66 patients, 50 patients, and 91 patients. The elevation of serum LDH was associated with several unfavorable parameters, including advanced age, continent cutaneous urinary diversion, increased neutrophil-to-lymphocyte ratio, decreased lymphocyte-to-monocyte ratio. Patients with a higher serum LDH (> 220 U/L) had a worse OS (P < 0.001), CSS (P < 0.001) and DFS (P < 0.001). Multivariate Cox analysis suggested that elevated LDH was an independent predictor for OS (hazard ratio [HR]: 3.113, 95% confidence interval [CI]: 1.524-6.358; P = 0.002), CSS (HR: 4.564, 95% CI: 2.008-10.373; P < 0.001), DFS (HR: 2.051, 95% CI: 1.125-3.739; P = 0.019). Medical history of diabetes, high pT stage, and positive lymph node also were adverse predictors for oncological outcomes of BCa patients in multivariate analysis.Conclusions: Preoperative serum LDH is an independent prognostic biomarker for OS, CSS, and DFS in patients undergoing radical cystectomy for BCa, which can be incorporated into prognostic models. [ABSTRACT FROM AUTHOR]