التفاصيل البيبلوغرافية
| العنوان: |
Antioxidant, Antiapoptotic and Inflammatory Effects of Interleukin-18 Binding Protein on Kidney Damage Induced by Hepatic Ischemia Reperfusion |
| المؤلفون: |
Mustafa Ozsoy, İbrahim Keleş, Mehmet Fatih Bozkurt, Afra Karavelioglu, Onder Cartilli, Ziya Taner Ozkececi, Yucel Gonul, Ahmet Kocak, Sefa Celik, Havva Kocak |
| بيانات النشر: |
Elsevier B.V., 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
Antioxidant, medicine.medical_treatment, Interleukin-1beta, Apoptosis, medicine.disease_cause, Kidney, Remote organ, chemistry.chemical_compound, Random Allocation, 0302 clinical medicine, Medicine, Urea, biology, Caspase 3, Liver Diseases, Acute kidney injury, Alanine Transaminase, General Medicine, Acute Kidney Injury, Recombinant Proteins, medicine.anatomical_structure, Biochemistry, Liver, 030220 oncology & carcinogenesis, Creatinine, Reperfusion Injury, Kidney injury, Intercellular Signaling Peptides and Proteins, 030211 gastroenterology & hepatology, Tumor necrosis factor alpha, medicine.medical_specialty, Aspartate transaminase, IL-18BP, Protective effect, 03 medical and health sciences, Interferon-gamma, Internal medicine, Lactate dehydrogenase, Animals, Aspartate Aminotransferases, Rats, Wistar, Inflammation, L-Lactate Dehydrogenase, business.industry, Interleukin-6, Tumor Necrosis Factor-alpha, medicine.disease, Rats, Oxidative Stress, Endocrinology, chemistry, biology.protein, business, Oxidative stress, Liver ischemia-reperfusion injury |
| الوصف: |
Objective Acute kidney injury (AKI) is a serious condition that can be induced by liver transplantation, major hepatic resection or prolonged portal vein occlusion. The AKI can increase the frequency of postoperative complications. In the current study, we aimed to investigate whether interleukin-18 binding protein (IL-18BP) pretreatment has a protective effect against possible kidney injury–mediated liver ischemia-reperfusion (IR) achieved by Pringle maneuver in an experimental rat model. Materials and Methods A total of 21 Wistar albino rats were included in this study. Animals were equally and randomly separated into 3 groups as follows: Sham (n = 7), IR group (n = 7) and IR + IL-18BP group (n = 7). Serum aspartate transaminase, alanine aminotransaminase and lactate dehydrogenase enzyme activities and serum urea and creatinine levels were determined. Tumor necrosis factor-?, IL-6, IL-1ß, interferon gamma, total oxidant status, total antioxidant status and oxidative stress index were measured in kidney tissue homogenate samples. Histopathological examination and immunohistochemical Caspase-3 staining were applied to examine the general morphologic structure and apoptosis. Results Renal total oxidant status; oxidative stress index; IL-18 levels; serum aspartate transaminase, alanine aminotransaminase and lactate dehydrogenase activities and creatinine levels were significantly lower in IR + IL-18BP group, when compared with the IR group. Beside this, total antioxidant status levels were remarkably higher in IR + IL-18BP group, when compared with the IR group. The caspase-3 expression degree in IR group was remarkably higher than other groups. Conclusions It has been demonstrated that IL-18BP pretreatment may have inflammatory, antioxidant and antiapoptotic effects against AKI induced by hepatic IR. © 2016 Southern Society for Clinical Investigation |
| اللغة: |
English |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fb31076e1fc6e8b78fe312c58bf0afTest
https://hdl.handle.net/20.500.12438/7521Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....c9fb31076e1fc6e8b78fe312c58bf0af |
| قاعدة البيانات: |
OpenAIRE |
