دورية أكاديمية
Graft-versus-Host Disease Prophylaxis with Post- Transplantation Cyclophosphamide in Chronic Myeloid Leukemia Patients Undergoing Allogeneic Hematopoietic Cell Transplantation from an Unrelated or Mismatched Related Donor: A Comparative Study from the Chronic Malignancies Working Party of the EBMT (CMWP-EBMT).
| العنوان: | Graft-versus-Host Disease Prophylaxis with Post- Transplantation Cyclophosphamide in Chronic Myeloid Leukemia Patients Undergoing Allogeneic Hematopoietic Cell Transplantation from an Unrelated or Mismatched Related Donor: A Comparative Study from the Chronic Malignancies Working Party of the EBMT (CMWP-EBMT). |
|---|---|
| المؤلفون: | Ortí, Guillermo, Gras, Luuk, Koster, Linda, Kulagin, Aleksander, Byrne, Jenny, Apperley, Jane F, Halaburda, Kazimierz, Blau, Igor Wolfgang, Clark, Andrew, Kröger, Nicolaus, Griskevicius, Laimonas, Carlson, Kristina, Collin, Matthew, Bloor, Adrian, Raiola, Anna Maria, Blaise, Didier, Aljurf, Mahmoud, López-Corral, Lucia, Sakellari, Ioanna, Beguin, Yves, Wrobel, Tomasz, de Rosa, Luca, de Lavallade, Hughes, Hayden, Patrick J, McLornan, Donal, Chalandon, Yves, Yakoub-Agha, Ibrahim |
| المصدر: | Transplantation and Cellular Therapy, 30, 93.e1 - 93.e12 (2024) |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2024 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Allogeneic hematopoietic cell transplantation, Chronic myeloid leukemia, Haploidentical donor, Post-transplantation cyclophosphamide, Unrelated donor, Cyclophosphamide, Adult, Humans, Chronic Disease, Cyclophosphamide/therapeutic use, Retrospective Studies, Unrelated Donors, Graft vs Host Disease/prevention & control, Hematopoietic Stem Cell Transplantation/adverse effects, Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy, Myeloid, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, BCR-ABL Positive, Immunology and Allergy, Molecular Medicine, Hematology, Cell Biology, Transplantation, Human health sciences, Sciences de la santé humaine, Hématologie |
| الوصف: | peer reviewed ; Outcomes following allogeneic hematopoietic cell transplantation (allo-HCT) for chronic myeloid leukemia (CML) with post-transplantation cyclophosphamide (PTCy) using an unrelated donor (UD) or a mismatched related donor (MMRD) remain unknown. We report a retrospective comparison of PTCy-based allo-HCT from a UD, non-PTCy allo-HCT from a UD, and PTCy allo-HCT from an MMRD. Inclusion criteria were adult patients with CML undergoing first allo-HCT between 2012 and 2019 from a UD with either PTCy or non-PTCy graft-versus-host disease (GVHD) prophylaxis or from an MMRD using PTCy. The primary endpoint was GVHD-free/relapse-free survival (GRFS). A total of 1341 patients were included (82% in the non-PTCy UD cohort). With a median follow-up of 34.9 months, the 3-year GRFS was 43% in the non-PTCy cohort, 37% in the PTCy-UD cohort, and 39% PTCy-MMRD cohort (P = .15). Multivariable analyses revealed no significant differences among the 3 cohorts in terms of overall survival (OS), progression-free survival, RI, and nonrelapse mortality. Factors independently associated with worse OS in the overall cohort were Karnofsky Performance Status <90 (hazard ratio [HR], 1.86; 95% confidence interval [CI], 1.41 to 2.45; P < .001), older age (HR, 1.24, 95% CI, 1.11 to 1.38; P < .001), and disease stage (compared to chronic phase [CP] 1): blast phase (HR, 2.25; 95% CI, 1.60 to 3.16; P < .001), accelerated phase (HR, 1.63; 95% CI, 1.05 to 2.54; P = .03), and CP >2 (HR, 1.58; 95% CI, 1.15 to 2.17; P = .005). These results suggest that allo-HCT in patients with CML using either a UD or an MMRD with PTCy-based GVHD prophylaxis are feasible transplantation, platforms and that the disease stage at allo-HCT remains a major prognostic factor, highlighting the importance of closely monitoring CML patients and proposing transplantation when indicated when still in CP1. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2666-6375 2666-6367 |
| العلاقة: | https://api.elsevier.com/content/article/PII:S2666636723015737?httpAccept=text/xmlTest; urn:issn:2666-6375; urn:issn:2666-6367; https://orbi.uliege.be/handle/2268/313455Test; info:hdl:2268/313455; https://orbi.uliege.be/bitstream/2268/313455/1/509.pdfTest; scopus-id:2-s2.0-85175423281; info:pmid:37783337 |
| DOI: | 10.1016/j.jtct.2023.09.019 |
| الإتاحة: | https://doi.org/10.1016/j.jtct.2023.09.019Test https://orbi.uliege.be/handle/2268/313455Test https://orbi.uliege.be/bitstream/2268/313455/1/509.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3D88A61 |
| قاعدة البيانات: | BASE |
| تدمد: | 26666375 26666367 |
|---|---|
| DOI: | 10.1016/j.jtct.2023.09.019 |