التفاصيل البيبلوغرافية
| العنوان: |
Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts |
| المؤلفون: |
Chiu, Po Yee, Lam, Philip Y., Yan, Chung Wai, Ko, Kam Ming bcrko@ust.hk |
| المصدر: |
Fitoterapia. Jun2011, Vol. 82 Issue 4, p682-691. 10p. |
| مصطلحات موضوعية: |
*MEDICINAL plants, *REACTIVE oxygen species, *ALTERNATIVE medicine, *ANALYSIS of variance, *BIOPHYSICS, *SIMULATION methods in education, *ENZYMES, *FIBROBLASTS, *GLUTATHIONE, *LACTATE dehydrogenase, *RESEARCH methodology, *METALLOPROTEINS, *RESEARCH funding, *SPECTROPHOTOMETRY, *SUNSHINE, *WESTERN immunoblotting, *PLANT extracts, *OXIDATIVE stress |
| مصطلحات جغرافية: |
CHINA, HONG Kong (China) |
| مستخلص: |
Abstract: The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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