التفاصيل البيبلوغرافية
| العنوان: |
Autoimmune and inflammatory diseases associated with chronic myelomonocytic leukemia: A series of 26 cases and literature review. |
| المؤلفون: |
Grignano, Eric1, Mekinian, Arsene1 arsene.mekinian@sat.aphp.fr, Braun, Thorsten2, Liozon, Eric3, Hamidou, Mohamed4, Decaux, Olivier5, Puéchal, Xavier6, Kahn, Jean Emmanuel7, Schoindre, Yoland7, Rossignol, Julien8, Lortholary, Olivier9, Lioger, Bertrand10, Hermine, Olivier8, Park, Sophie11, Ades, Lionel12, Montestruc, François13, Ricard, Laure1, Gardin, Claude2, Fenaux, Pierre12, Fain, Olivier1 |
| المصدر: |
Leukemia Research. Aug2016, Vol. 47, p136-141. 6p. |
| مصطلحات موضوعية: |
*AUTOIMMUNE diseases, *RETROSPECTIVE studies, *INFLAMMATION treatment, *CHRONIC myeloid leukemia, *STEROID drugs, *DIAGNOSIS, *THERAPEUTICS, MEDICAL literature reviews |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
We wanted to describe the characteristics, treatment and outcome of autoimmune and inflammatory diseases (SAIDs) associated with chronic myelomonocytic leukemia (CMML), and conducted a French multicenter retrospective study and a literature review. We included 26 cases of CMML (median age 75 years, 54% female), 80% with CMML-1. CPSS score was low (0 or 1) in 75% of cases. SAIDS was systemic vasculitis in 54%. Diagnosis of the 2 diseases was concomitant in 31% cases, and CMML was diagnosed before SAIDs in 12 cases (46%). First line treatment for SAIDs consisted mostly of steroid, with 85% of response. Second-line treatment was needed in 40% cases. Six patients received hypomethylating agents, with 66% response on SAIDs. A literature review found 49 cases of CMML-associated SAIDs, in whom SAIDs was systemic vasculitis in 29% cases. Hence, vasculitis is the most frequent SAIDs associated with CMML. After initial response to steroids, recurrence and steroid-dependence were frequent. Hypomethylating agents may be interesting in this context. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
