التفاصيل البيبلوغرافية
| العنوان: |
A novel scheme for the validation of an automated classification method for epileptic spikes by comparison with multiple observers. |
| المؤلفون: |
Sharma, Niraj K.1 niraj.sharma.14@ucl.ac.uk, Pedreira, Carlos2, Centeno, Maria1, Chaudhary, Umair J.1, Wehner, Tim1, França, Lucas G.S.1, Yadee, Tinonkorn1, Murta, Teresa1, Leite, Marco1, Vos, Sjoerd B.1,3, Ourselin, Sebastien1,3,4, Diehl, Beate1, Lemieux, Louis1 |
| المصدر: |
Clinical Neurophysiology. Jul2017, Vol. 128 Issue 7, p1246-1254. 9p. |
| مصطلحات موضوعية: |
*EPILEPSY, *SOCIAL segmentation, *PEOPLE with epilepsy, *CHRONICALLY ill, *INFORMATION science |
| مستخلص: |
Objective To validate the application of an automated neuronal spike classification algorithm, Wave_clus (WC), on interictal epileptiform discharges (IED) obtained from human intracranial EEG (icEEG) data. Method Five 10-min segments of icEEG recorded in 5 patients were used. WC and three expert EEG reviewers independently classified one hundred IED events into IED classes or non-IEDs. First, we determined whether WC-human agreement variability falls within inter-reviewer agreement variability by calculating the variation of information for each classifier pair and quantifying the overlap between all WC-reviewer and all reviewer-reviewer pairs. Second, we compared WC and EEG reviewers’ spike identification and individual spike class labels visually and quantitatively. Results The overlap between all WC-human pairs and all human pairs was >80% for 3/5 patients and >58% for the other 2 patients demonstrating WC falling within inter-human variation. The average sensitivity of spike marking for WC was 91% and >87% for all three EEG reviewers. Finally, there was a strong visual and quantitative similarity between WC and EEG reviewers. Conclusions WC performance is indistinguishable to that of EEG reviewers’ suggesting it could be a valid clinical tool for the assessment of IEDs. Significance WC can be used to provide quantitative analysis of epileptic spikes. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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