Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma
| العنوان: | Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma |
|---|---|
| المؤلفون: | E. Gallego, Antonio Tejera-Vaquerizo, José Aguilera, Andrea Cavalcanti, Susana Puig, Ángel Pla, Eduardo Nagore, Emilie Lannoy, Caroline Robert, Philippe Aegerte, Victor Traves, Celia Requena, Lucia Alos, Josep Palou, Carlos Guillén, Cristina Carrera, Virtudes Soriano, Antonio Vilalta-Solsona, Isidro Bolumar, Paula Martín-Cuevas, Naima Benannoune, Philippe Saiag, Ramón Rull, Sergi Vidal-Sicart, Gorana Tomasic, Josep Malvehy, Enrique Herrera-Acosta, Celine Boutros, Enrique Herrera-Ceballos |
| المساهمون: | Universitat de Barcelona |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | Elsevier B.V. |
| مصطلحات موضوعية: | Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Skin Neoplasms, Time Factors, Waiting Lists, Sentinel lymph node, Nodes limfàtics, Kaplan-Meier Estimate, Article, Disease-Free Survival, Tertiary Care Centers, Breslow Thickness, Predictive Value of Tests, Risk Factors, Internal medicine, Biopsy, medicine, Humans, Skin cancer, Melanoma, Lymph nodes, History, Ancient, Càncer de pell, Aged, Proportional Hazards Models, Retrospective Studies, medicine.diagnostic_test, Sentinel Lymph Node Biopsy, business.industry, Hazard ratio, Retrospective cohort study, Middle Aged, Sentinel node, medicine.disease, Surgery, Treatment Outcome, Spain, Lymphatic Metastasis, Cutaneous melanoma, Female, France, Lymph Nodes, business |
| الوصف: | Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results: A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2-2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4-10.7), ulceration (HR, 1.6; CI, 1.1-2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9-4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419715f82da1a0fb5ccfda92616e005dTest http://hdl.handle.net/2445/130565Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....419715f82da1a0fb5ccfda92616e005d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |