التفاصيل البيبلوغرافية
| العنوان: |
The clearance time of infused hematopoietic stem cell from the blood circulation. |
| المؤلفون: |
Donmez, Ayhan1 ayhan.donmez@ege.edu.tr, Ozsan, Fatma2 ftmnefro@yahoo.com, Arik, Bahar1 bahar.arik@ege.edu.tr, Ozkayin, Nese3 neseozkayin@hotmail.com, Çagirgan, Seckin1 seckin.cagirgan@ege.edu.tr, Mir, Sevgi2 sevgi.mir@ege.edu.tr, Vural, Filiz1 filiz.vural@ege.edu.tr, Tombuloglu, Murat1 murat.tombuloglu@ege.edu.tr |
| المصدر: |
Transfusion & Apheresis Science. Apr2013, Vol. 48 Issue 2, p235-239. 5p. |
| مصطلحات موضوعية: |
*HEMATOPOIETIC stem cell transplantation, *BLOOD circulation, *BLOOD testing, *BLOOD cells, *BLOOD platelets, *CYTOMETRY |
| مستخلص: |
Abstract: There is no detailed information about the clearance time of infused hematopoietic stem cell (HSC) from the blood circulation in humans. In this prospective study, peripheral blood CD34+ cell counts were detected during the 4days period following autologous HSC transplantation in 20 patients by means of flow cytometry. The median CD34+ cells were at the highest level in the first hour and decreased below pre-infusion values on the first day after HSC infusion. By nonparametric analysis, positive correlation was found between CD34+ cell levels at the first hour and the post-thaw CD34+ cell dose (r =0.57, p =0.01). An inverse correlation was determined between CD34+ cell levels at the first hour and neutrophil engraftment (r =−0.54, p =0.01). Compared with the patients having CD34+ cell count of ⩾2μL−1 in the first hour following HSC infusion, the patients having CD34+ cell count of <2μL−1 had delayed both neutrophil (20 vs. 12, p =0.008) and platelet (47 vs. 11, p =0.01) engraftments. Our results indicated that infused HSCs were removed from the blood circulation within 1day. In addition, CD34+ cell levels at the first hour may be used as an important indicator to predict the delay of neutrophil and platelet engraftments. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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