التفاصيل البيبلوغرافية
| العنوان: |
Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study. |
| المؤلفون: |
Chbili, Chahra1 (AUTHOR) chahrachbili@yahoo.fr, Fathallah, Neila2 (AUTHOR), Laadhari, Chayma2 (AUTHOR), Ouni, Bouraoui2 (AUTHOR), Saguem, Saad1 (AUTHOR), Ben Fredj, Maha1 (AUTHOR), Abdelghani, Ahmed3 (AUTHOR), Ben Saad, Helmi1,4,5,6 (AUTHOR), Ben Salem, Chaker1,2 (AUTHOR) |
| المصدر: |
Gene. Jan2022, Vol. 809, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*GENETIC polymorphisms, *ANTITUBERCULAR agents, *TUBERCULOSIS, *HEPATOTOXICOLOGY, *CASE-control method, *DRUG side effects, *DRUG therapy |
| مستخلص: |
• Many anti-tuberculosis drugs are responsible for cases of hepatotoxicity. • The impact of GSTs gene polymorphisms on hepatotoxicity is still limited in Tunisians. • Significant association between GSTM1/T1 null genotype and ATDH. • Association of GSTP1 polymorphism and risk of ATDH. • Genetic analysis could be useful by offering targeted treatments. GST non-functional genotypes can lead to the accumulation of toxic intermediates, resulting in liver damage and increasing susceptibility to ATDH. To investigate the impact of GST Mu (GSTM1), GST Theta (GSTT1) null genotypes, and GST Pi (GSTP1; adenosine (A) > guanine (G), rs1695) variant allele on the development of ATDH in Tunisian patients treated with anti-tuberculosis therapy. This was a case-control study including patients receiving anti-tuberculosis regimen. Cases (n = 23) were tuberculosis patients presenting ATDH during two months of anti-tuberculosis drug therapy. Controls (n = 30) were patients treated for tuberculosis, but presenting no ATDH. Genotyping was performed using a polymerase chain reaction-restriction fragment length polymorphism. No statistically significant association was observed between GSTM1 and GSTT1 homozygous null genotypes, and the risk of ATDH. A statistically significant association between GSTM1 and GSTT1 double null genotypes, and the risk of ATDH was found (p = 0.033) between cases and controls. For GSTP1, the distribution of GG homozygous mutant genotype was significantly associated with ATDH compared with the wild and the transition A to G (AA + AG) genotypes. Double deletion of GSTM1 and GSTT1 may predispose to ATDH in a Tunisian population. Moreover, GSTP1 rs1695 (A > G) genotyping can predict susceptibility to developing ATDH. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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